4-Nitroquinoline-l-oxid

It would be interesting to know if the mutational consequences of DNA lesions in mammalian cells were the same as those which obtain in bacteria. Methods for retrieving and sequencing mutations in mammalian cells and their viruses are now being developed (81-83) If yeast, a eukaryotic microorganism, can be considered representative of higher eukaryotes, then judging from the observations that the mutational spectra for UV-irradiation and 4-nitroquinoline-l-oxide treatment are identical for yeast (84) and bacteria (85), the spectrum of mutations induced by BPDE in mammalian cells could well resemble those induced in E. coli. 

Diekmann, M., Waldmann, P., Schnurstein, A., Grummt, T, Braunbeck, T. and Nagel, R. (2004) On the relevance of genotoxicity for fish populations 11 genotoxic effects in zebrafish [Danio rerio) exposed to 4-nitroquinoline-l-oxide in a complete life-cycle test. Aquatic Toxicology, 68, 27-37. 

Sugimura, T., Okabe, K., and Nagao, M. (1966). The metabolism of 4-nitroquinoline-l-oxide, a carcinogen. 3. An enzyme catalyzing the conversion of 4-nitroquinoline-l-oxide to 4-hydroxyaminoquinoline-l-oxide in rat liver and hepatomas. Cancer Res. 26 1717-1721. 

SYNS 4-NITROCHINOLIN N-OXID (SWEDISH) 4-NITROQUINOLINE-l-OXIDE 4-NQO... 

Mitomycin C (MMC) and 4-nitroquinoline-l-oxide (4NQO) are known to be mutagenic to human lymphocytes. When cells were exposed to each of these and RF, synergistic effects were observed. DNA damage was greater than that observed for MMC or 4NQO alone/38 ... 

The rare skin condition. Xeroderma pigmentosum (XP), is characterised by extreme sensitivity to sunlight and a predisposition to skin cancer. Cells taken from persons suffering from this condition are more sensitive to UV-irradiation than normal cells and are deficient in excision repair of UV-induced damage. These same cells are also sensitive to other DNA damaging agents such as hydrocarbon epoxides, 4-nitroquinoline-l-oxide and... 

Inayama, Y., Promoting action of glycerol in pulmonary tumorigenesis model using a single administration of 4-nitroquinoline-l-oxide in mice. Jan. J. Cancer Res., 77, 345 (1986). 

Nitroquinoline-l -oxide Epstein and Shafner (1968) (male) Mouse... 

Figure 2.6. Dose-response dependence of concentrated culture liquid ofF. shermanii against mutagenicity of 4-nitroquinoline-l-oxide. The Ames test was carried out with 4-nitroquinoline-1-oxide as the mutagen and Salmonella typhimurium TAIOO as the test organism. Sixfold concentrated culture liquid was added at doses indicated. From Vorobjeva etal. (1993b).

Vorobjeva LI, Cherdinceva TA and Abilev SK (1995a) Antimutagenic effect of bacteria on mutagenesis induced by 4-nitroquinoline-l-oxide in Salmonella typhimurium. Microbiology 64 187-192... 

Nitro-o-phenylenediamine 2-Nitro-/ -phenylenediamine 4-Nitroquinoline-l-oxide (4-NQO)... 

The BALB/c 3T3 cell line developed by Aaronson and Todaro has been extensively used for studies with oncogenic viruses. More recently, clones of this cell line have been used to establish quantitative focus assays in which transformation was demonstrated with several polycyclic aromatic hydrocarbons, A -acetoxy-2-acetylaminofluorene, 4-nitroquinoline-l-oxide, afla-toxin Bi, and A -methyl-A/ -nitro-A -nitrosoguanidine. Foci were not observed with diethylnitrosamine, dimethylnitrosamine, or a number of noncarcinogens. 

---