Oncogenic virus

The Rous sarcoma virus oncogene v-src and a family of related oncogenes are derived from protein tyrosine kinases that are attached with the aid of a... 

Franken, M., Devergne, O., Rosenzweig, M., Annis, B., Kieff, E., and Wang, F. (1996). Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMPl. 

Ans. Retroviruses are RNA viruses that reproduce through the intermediate formation of DNA. The retrovirus contains genetic information for the synthesis of the enzyme reverse tramcriptase. Reverse transcriptase, synthesized using the host cell s mechanism for protein synthesis, directs the synthesis of viral DNA from viral RNA. Subsequently, the host reproduces the viral RNA using the DNA as a template. The retroviruses include HIV and cancer-causing viruses (oncogenic viruses). 

Hiscott J, Nguyen TL, Arguello M et al. Manipulation of the nuclear factor-kappaB pathway and the innate immune response hy viruses. Oncogene 2006 25(51) 6844-6867. 

Abbreviations Akt AKT8 virus oncogene cellular homologue... 

Many animal viruses, particularly the oncogenic viruses—either directly or, in the case of RNA viruses such as HIV that causes AIDS, their DNA transcripts generated by the action of the viral RNA-dependent... 

Infection by viruses carrying oncogenes can cause malignant cell growth. Although first recognized as causative agents in avian cancers 90 years ago, for much of the twentieth century there was doubt that any human cancers were initiated in this way. Even now, almost all the information in this area refers to nonhuman animals, which presents a number of problems. First, as was already... 

Evidence for the first oncogene was found when certain mutants of RSV failed to transform cells at high temperature but did transform cells at low temperature. The mutant virus replicated well at both temperatures. This means that the virus contained a tem-perature-sensitive mutation in a gene that coded for a sarcoma-producing protein, that is, for v-src. 

Fogel, M. and Defendi, V. (1967) Infections of muscle cultures from various species with oncogenic DNA viruses (SV40 and Polyoma). Proceedings of the National... 

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