Tumorigenesis model

Lu G, Liao J, Yang G, Reuhl KR, Hao X, Yang CS. 2006a. Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-l-(3-pyridyl)-l-buta-none-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. Cancer Res 66 11494—11501. 

Following this experimental design, approximately 700 plant materials have been evaluated and this has resulted in over 6,500 bioassay results. A number of active principles have been obtained that are active with the in vitro test systems, and several of the isolates have retained activity by preventing formation of preneoplastic lesions in mammary organ culture. Thus far, three lead compounds have been shown to mediate considerable cancer chemopreventive activity in full-term tumorigenesis models (28,34,45,46) and are being studied in more advanced test systems. We remain hopeful that one or more discoveries resulting from this project will be deemed worthy of human intervention trials. 

Recent studies with the mouse skin tumorigenesis model have revealed fascinating quantitative differences in the response of the target tissue to initiating or promoting agents. As reported by Boutwell, the tumor response induced by repetitive... 

Yang, G., Wang, Z.Y., Kim, S., Liao, J., Seril, D.N., Chen, X., Smith, T.J., and Yang, C.S., Characterization of early pulmonary hyperprohferation and tumor progression and their inhibition by black tea in a 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone-induced lung tumorigenesis model with A/J mice. Cancer Res. 57,1889-1894,1997. 

Inayama, Y., Promoting action of glycerol in pulmonary tumorigenesis model using a single administration of 4-nitroquinoline-l-oxide in mice. Jan. J. Cancer Res., 77, 345 (1986). 

FEARON E R and VOGELSTEIN B (1990) A genetic model for colorectal tumorigenesis . Cell, 16, 759-67. 

Lian, F., D. E. Smith, H. Ernst, R. M. Russell, and X. D. Wang. 2007. Apo-lO -lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 28(7) 1567-1574. 

Kota J, Chivukula RR, O Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT (2009) Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137 1005-1017... 

In addition to their possible prooxidant activity (see above) polyphenols and flavonoids may influence cancer cells via their antioxidant properties. Recently, Jang et al. [219] studied cancer chemopreventive activity of resveratrol, a natural polyphenolic compound derived from grapes (Chapter 29). These authors showed that resveratrol inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. Flavonoids silymarin and silibinin also exhibited antitumor-promoting effects at the stage I tumor promotion in mouse skin [220] and manifested antiproliferative effects in rat prostate cancer cells [221]. 

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