Nitric oxide cell differentiation

Kudo FA, Warycha B, Juran PJ, Asada H, Teso D, Aziz F (2005) Differential responsiveness of early- and late-passage endothehal cells to shear stress. Am J Surg 190(5) 763-769 Lee RH, Efron D, Tantry U, Barbul A (2001) Nitric oxide in the healing wound a time-course study. J Surg Res 101(1) 104-108... 

The effect of MAPK activation on cellular processes that affect cell function and the resulting pharmacology has been delineated using modem techniques such as knock-out cells and animals [1,3,6]. Activation of MAPK in inflammatory cells such as T-cells, B-cells, macrophages and eosinophils leads to expression and/or activation of pro-inflammatory genes and mediators such as interleukin-1(3 (IL-1(3), TNFa, IL-6, chemokines [e.g., IL-8, macrophage inflammatory factor-1 a, (3 (MIP-la,[3)J, MMPs and toxic molecules such as free radicals and nitric oxide [1,3]. These pro-inflammatory mediators induce cellular proliferation, differentiation, survival, apoptosis and tissue degradation/destruction and help induce chronic inflammation. Inhibition of any one or more of the MAPK family... 

Bhaumik S, Jyothi MD, Khar A. 2000. Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells. FEBS Lett 483 78-82. 

Cherrg A, Warrg S, Cai J, Rao MS, Mattsorr MP (2003) Nitric oxide acts irr a positive feedback loop witlr BDNF to regulate neural progenitor cell proliferation widr differentiation irr tire mammaliarr brairr. Dev Biol 258 319-333. 

Mitrovic B, Ignarro LJ, Montestruque S, SmoU A Merrill JE (1994) Nitric oxide as a potential pathological mechanism in danyehnation Its differential effects on primary ghal cells in vitro. Neuroscience 61 575-585. 

Topper JN, Cai J, Falb D, Gimbrone MA Jr. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 1996 93(19) 10417-22. 

Salh B, Wagey R, Marotta A, Tao JS, Pelech S. 1998. Activation of phosphati-dylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J. Immunol. 161 6947-54... 

Pisu MB, Guioli S, Conforti E, Bernocchi G (2003) Signal molecules and receptors in the differential development of cerebellum lobules. Acute effects of cisplatin on nitric oxide and glutamate systems in Purkinje cell population. Brain Res Dev Brain Res 145 229-240. 

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