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Neural embryonic stem cells

Theimissen PT et al (2012) Dose-response toxicogenomic evaluation of valproic acid, cyproconazole and hexaconazole in the neural embryonic stem cell test (ESTn). Toxicol Sci 125(2) 430 38... [Pg.472]

Kim E, Clark AL, Kiss A, Hahn JW, Wesselschmidt R, Coscia CJ, Belcheva MM (2006) Mu and kappa opioids induce the differentiation of embryonic stem cells to neural progenitors. J Biol Chem 281 33749-33760... [Pg.371]

Ronaghi M, Erceg S, Moreno-Manzano V, Stojkovic M (2010) Challenges of stem cell therapy for spinal cord injury Human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells Stem Cells 28 93-99... [Pg.198]

Brain cells can be derived from embryonic stem cells 510 Brain cells may also be derived from non-neural stem cells 511... [Pg.503]

Stavridis, M. P. and Smith, A. G. Neural differentiation of mouse embryonic stem cells. Biochem. Soc. Trans. 31 45-49, 2003. [Pg.515]

Bain G, Ray WJ, Yao M et al (1996) Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture. Biochem Biophys Res Commun 223(3) 691-694... [Pg.340]

Theunissen PT, Schulpen SH, van Dartel DA et al (2010) An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury. Reprod Toxicol 29(4) 383-392... [Pg.340]

Theimissen PT et al (2011) Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. Toxicol Sci 122(2) 437 47... [Pg.472]

Survival and differentiation of neural progenitor cells derived from embryonic stem cells and transplanted into ischemic brain. Takagi, Y., Nishimura, M., Morizane, A., Takahashi, J., Nozaki, K., Hayashi, J., Hashimoto, N. (2005). JNeurosurg, 103 (2) 304-310. [Pg.58]

Munoz-Sanjuan I, Biivanlou AH (2002) Neural induction, the default model and embryonic stem cells. Nat Rev Neurosci 3 271-280. [Pg.460]

Due to the limited applicability of in silico SAR approaches for developmental toxicity, there is more reliance on in vitro screening. From what has been publicly disclosed, it is evident that the four in vitro tests used for industrial screening are chick embryonic neural retina (CENR) micromass culture, whole embryo culture (WEC, rodent or rabbit), and mouse embryonic stem cells (EST). Recently, there has been significant interest within the pharmaceutical industry in the use of zebrafish for developmental toxicity testing,30 but because this aspect is in its infancy, there is little that has been publicly disclosed except limited abstracts and slide decks at several workshops.31 Although reviewed in considerable detail elsewhere,30-32 36 each test will be briefly compared and contrasted here. [Pg.159]

Figure 9-5 The sensitivity of the conceptus to a theoretical teratogen during rat gestation (modified from 161). The most susceptible window is organogenesis with low levels of vulnerability at the time of implantation and the period of functional maturation. Superimposed are the approximations of when the developmental landmarks that are represented in the four in vitro tests occur. The chick embryo neural retina model (CENR) represents events around GD 10-13. The mouse embryonic stem cell test (EST) corresponds roughly to the period of GD 6-10 in the rat, near the peak of sensitivity. Whole embryo culture (WEC) recapitulates the window at the peak of sensitivity, between GD 9-11 or GD 10-12 depending upon the window within which the culture is conducted. Rabbit cultures are also done between GD 10-12. Represented by the single ( ) and double asterisk ( ), respectively, are the initiation and termination of the dosing period in regulatory compliant preclinical embryo/fetal toxicity studies. Thus, the zebrafish is the only model that permits exposure to test article during this important period. Figure 9-5 The sensitivity of the conceptus to a theoretical teratogen during rat gestation (modified from 161). The most susceptible window is organogenesis with low levels of vulnerability at the time of implantation and the period of functional maturation. Superimposed are the approximations of when the developmental landmarks that are represented in the four in vitro tests occur. The chick embryo neural retina model (CENR) represents events around GD 10-13. The mouse embryonic stem cell test (EST) corresponds roughly to the period of GD 6-10 in the rat, near the peak of sensitivity. Whole embryo culture (WEC) recapitulates the window at the peak of sensitivity, between GD 9-11 or GD 10-12 depending upon the window within which the culture is conducted. Rabbit cultures are also done between GD 10-12. Represented by the single ( ) and double asterisk ( ), respectively, are the initiation and termination of the dosing period in regulatory compliant preclinical embryo/fetal toxicity studies. Thus, the zebrafish is the only model that permits exposure to test article during this important period.
Figure 9-6 A generic strategy integrating the three facets of developmental toxicity risk assessment namely (a) the risk of pharmacologic modulation of the therapeutic target during gestation, (b) in silico, SAR and (c) in vitro screening. Abbreviations The chick embryo neural retina (CENR) embryonic stem cell test (EST), whole embryo culture (WEC), Good Laboratory Practice (GLP), Embryo/Fetal Developmental Toxicity (EFD) study. "Front-loading" is the conduct of the EFD study prior to Phase lib. Figure 9-6 A generic strategy integrating the three facets of developmental toxicity risk assessment namely (a) the risk of pharmacologic modulation of the therapeutic target during gestation, (b) in silico, SAR and (c) in vitro screening. Abbreviations The chick embryo neural retina (CENR) embryonic stem cell test (EST), whole embryo culture (WEC), Good Laboratory Practice (GLP), Embryo/Fetal Developmental Toxicity (EFD) study. "Front-loading" is the conduct of the EFD study prior to Phase lib.
Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA (2001) In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 19 1129-1133... [Pg.142]

Embryonic stem cell-based tests for Interference with differentiation into cardiac cells neural Hazard identification of... [Pg.274]

Colleoni S, Galli C, Caspar JA, Meganathan K, Jagtap S, Hescheler J, Sachinidis A, Lazzari G (2011) Development of a neural teratogenicity test based on human embryonic stem cells response to retinoic acid exposure. Toxicol Sci 124 370-377... [Pg.283]

Visan A, Hayess K, Sittner D, Pohl EE, RiebelingC,SlawikB, GulichK, Oelgeschlager M, Luch A, Seiler AE (2012) Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro. Neurotoxicology 33(5) 1135-1146... [Pg.369]

Reubinoff BE, Itsykson P, Turetsky T, Pera MF, Reinhartz E, Itzik A, Ben-Hur T (2001) Neural progenitors from human embryonic stem cells. Nat Biotechnol 19(12) 1134—1140... [Pg.371]

Bertram CM, Hawes SM, Egli S, Peh SL, Dottori M, Kees UR, Dallas PB (2010) Effective adenovirus-mediated gene ttansfer into neural stem cells derived from human embryonic stem cells. Stem Cells Dev 19(4) 569-578... [Pg.371]

Liu J, Githinji J, Mclaughlin B, Wilczek K, Nolta J (2012) Role of miRNAs in neuronal differentiation from human embryonic stem cell-derived neural stem cells. Stem Cell Rev 8(4) 1129-1137... [Pg.371]

Fathi A, Hatami M, Hajihosseini V, Fattahi F, Kiani S, Baharvand H, Salekdeh GH (2011) Comprehensive gene expression analysis of human embryonic stem cells during differen-tiationinto neural cells. PLoS One 6(7) e22856... [Pg.372]

Shin S, Sun Y, Liu Y, Khaner H, Svant S, Cai J, Xu QX, Davidson BP, Stice SL, Smith AK, Goldman SA, Reubinoff BE, Zhan M, Rao MS, Chesnut JD (2007) Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue. Stem Cells 25(5) 1298-1306... [Pg.372]

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See also in sourсe #XX -- [ Pg.462 , Pg.463 ]



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