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Whole genome analysis

It should be possible to extend the DNA microarray-binding experiment to whole-genome analysis of transcription factor binding sites. The authors suggest that a microarray spotted with 12,000 one-kilobase sequences would span the entire Saccharomyces cerevisiae genome (Bulyk et al., 2001). Such an array could be used to characterize the sequence specificity of S. cerevisiae transcription factors. These experiments would be useful for predicting functions of previously uncharacterized transcription... [Pg.100]

Price, A.L., Eskin, E., Pevner, P.A. (2004) Whole-genome analysis of Alu repeat elements reveals complex evolutionary history. Genome Res., 14, 2245-2252. [Pg.330]

Bioinformatics tools can be useful in whole genome analysis for some of the following tasks ... [Pg.427]

In summary, from the simplest nucleotide substitution to the complex whole-genome analysis, Genomics has developed tools which discover and measure to the highest precision any possible alteration of genomes, transcrip-tomes, or epigenomes, making available an invaluable tool to explain and eventually find a way to treat cancer. [Pg.68]

The contribution of in silico models to vaccine development comprises algorithms for accelerated in silico identification of relevant protein candidates in silico design of novel immunogens with improved expression, safety, and immunogenicity profiles and in silico design of nucleic acid-based, vectored, or live attenuated vaccines. In small molecule development, in silico models play a major role in comparative genomics, whole genome analysis,... [Pg.272]

Raymond L, Zhaxybayeva O., Gogarten J. P., Gerdes S. Y., and Blankenship R. E. (2002) Whole-genome analysis of photosynthetic prokaryotes. Science 298(5598), 1616-1620. [Pg.3928]

Shin S, Sun Y, Liu Y, Khaner H, Svant S, Cai J, Xu QX, Davidson BP, Stice SL, Smith AK, Goldman SA, Reubinoff BE, Zhan M, Rao MS, Chesnut JD (2007) Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue. Stem Cells 25(5) 1298-1306... [Pg.372]

Gaasterland, T., and M. Oprea. 2001. Whole-genome analysis Annotations and updates. Curr Opin Struct Biol 11 377-81. [Pg.281]

DNA microarrays may also be used for whole genome analysis of single nucleotide polymorphisms (SNPs) and for chromosome copy number change. ... [Pg.50]

The heat shock response in E. coli is arguably the best studied stress response in terms of both the scope and function of its target genes (reviewed in Gross, 1996). Whole genome analysis began in earnest with... [Pg.350]

Stathopoulos, A., et al. 2002. Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo. Cell 111 687-701. [Pg.654]

Pan, G., Tian, S., Nie, J. et al. 2007. Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell 1 299-312. [Pg.755]

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