Nausea motion sickness

Key Words Zingiber officinale nausea motion sickness. 

This compound has antihistaminic activity and is usehil in the therapy of motion sickness. It may also be effective in the control of post-operative nausea and vomiting. It is classified as FDA Category B for Pregnancy, ie, no demonstrated risks shown in animal studies however, no controlled trials in pregnant women. Large doses may cause drowsiness and dry mouth owing to decreased secretion of saUva. 

It is important to note diat antivertigo dragp are essentially antiemetics because many of these preparations, whedier used for motion sickness or vertigo, also have direct or indirect antiemetic properties. They prevent the nausea and vomiting diat occur because of stimulation of die vestibular apparatus in the ear. Stimulation of diis apparatus results in vertigo, which is often followed by nausea and vomiting. 

HCI dye-fen-hye - dra-meen generic of cough, allergies, sleep aid, motion sickness, Parkinson s disease mild dizziness, constipation, nausea, Gl upset, skin eruptions, postural hypotension to exceed 150 mg/d children (6—42 years) 25 mg PO q4h (not to exceed 75 mg/d) children 2-6 years old, 6.25 mg q4h (not to exceed 25 mg/d)... 

Recommend a treatment regimen for a patient with nausea and vomiting associated with cancer chemotherapy, surgery, pregnancy, or motion sickness. 

Motion sickness is caused by stimulation of the vestibular system. This area contains many histaminic (Hj) and muscarinic cholinergic receptors. The higher brain (i.e., cerebral cortex) is affected by sensory input such as sights, smells, or emotions that can lead to vomiting. This area is involved in anticipatory nausea and vomiting associated with chemotherapy. 

Antihistamines are commonly used to prevent and treat nausea and vomiting due to motion sickness, vertigo, or migraine headache.1,17 Their efficacy is presumably due to the high concentration of histamine (Hx) and muscarinic cholinergic receptors within the vestibular system. Similarly to scopolamine, antihistamines such as diphenhydramine and... 

A 28-year-old healthy woman seeks your advice. She is about to leave on a 7-day Caribbean cruise and is concerned about motion sickness. She recently experienced nausea and one episode of vomiting while on a sailboat on Lake Michigan for an afternoon. She is not allergic to any medications. She does not smoke and only occasionally drinks alcohol. She takes an oral contraceptive (ethinyl estradiol and norgestimate) and occasional ibuprofen for headaches. 

Applied to the skin in a transdermal patch (tra ns dermal therapeutic delivery systemX this drug is used to prevent or reduce the occurrence of nausea and vomiting that are associated with motion sickness. 

The answer is e. (Hardmanr p 930.) All the drugs listed in the question are used as antiemetics. Chlorpromazine is a general antiemetic, used orally, rectally, or by injection for the control of nausea and vomiting that is caused by conditions that are not necessarily defined. Ondansetron is indicated in the oral or intravenous route for the prevention of nausea and vomiting caused by cancer chemotherapy Diphenhydramine and dimen-hydrinate are used orally for the active and prophylactic treatment of motion sickness. Scopolamine is a transdermal preparation used in the prevention of motion sickness. The drug is incorporated into a bandage-like... 

Domperidone is a dopamine antagonist that acts on the chemoreceptor trigger zone. It can therefore be used as an anti-emetic in nausea and vomiting, for example, to counteract side-effects of cytotoxic therapy and to treat nausea associated with dopaminergic drugs used in Parkinson s disease. Unlike hyoscine butlybromide and antihistamines, domperidone is ineffective in motion sickness. 

Promethazine Promethazine also is indicated for preoperative, postoperative, or obstetric sedation prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery an adjunct to analgesics for control of postoperative pain sedation and relief of apprehension, and to produce light sleep antiemetic effect in postoperative patients active and prophylactic treatment of motion sickness (oral and rectal only). 

Motion sickness, vestibuiar system disease Prevention and treatment of nausea, vomiting, and dizziness of motion sickness. 

Adults A 50 mg dose usually alleviates nausea. In severe cases, 150 mg/day may be taken. Usual maintenance dose is 50 mg, 2 times/day. In prevention of motion sickness, take 50 mg at least hour before beginning travel. For extended travel, a second 50 mg dose may be taken after 4 to 6 hours. 

Scopolamine inhibits excessive motility and hypertonus of the Gl tract in irritable colon syndrome, mild dysentery, diverticulitis, pylorospasm, and cardiospasm. Transdermal patch Prevention of nausea and vomiting associated with motion sickness and recovery from anesthesia and surgery in adults. 

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