Therapeutics delivery

S Vemuri, CT Rhodes. Preparation and characterization of liposomes as therapeutic delivery systems a review. Pharm Acta Helv 70(2) 95—111, 1995. 

Applied to the skin in a transdermal patch (tra ns dermal therapeutic delivery systemX this drug is used to prevent or reduce the occurrence of nausea and vomiting that are associated with motion sickness. 

Classical drug delivery — Advanced Therapeutics Delivery... 

Particulate systems (e.g., collagen, lactic or glycolic acids, polyanhydride or polyethylene vinyl coacetate) have several potential advantages for the therapeutic delivery of DNA (or of drugs), such as DNA encapsulation within the polymer can protect DNA degradation until release injection or implantation of the polymer into the... 

Dahlof C. Clinical applications of new therapeutic deliveries in migraine. Neurology. 2003 61 (suppl 4) S31-S34. 

Hortelano, G., Wang, L., Xu, N. and Ofosu, F. A. (2001). Sustained and therapeutic delivery of factor IX in nude haemophilia B mice by encapsulated C2C12 myoblasts Concurrent tumourigenesis. Haemophilia 7, 207-214. 

The combination of a metal carbonyl compound and a guanylate cyclase stimulant (e.g. YC-1) or stabiliser for the therapeutic delivery of carbon monoxide [240]... 

Motterlini RA, Mann BE (2002) Preparation of metal complexes for therapeutic delivery of carbon monoxide as vasodilator. Patent WO 2002/092075... 

Motterlini RA, Mann BE, Johnson TR, Scapens DA, Aqil R (2007) Therapeutic delivery of carbon monoxide via organometallic complexes. Patent WO 2007/085806... 

Most accounts of the Watt/Beddoes collaboration have purveyed a standard story, told with variations of emphasis.103 That story has Watt driven by personal and humanitarian interest in finding better therapies for consumption. It portrays him as a politically and philosophically calming influence upon the more radical, volatile and enthusiastic Beddoes. It concentrates on Watt s construction of an apparatus, his hints and cautions about its use for production of airs and their therapeutic delivery to patients. There has been, however, no serious attempt to understand and interpret the ideas about airs that Watt brought to, and took from, the project. Nor have Watt s ideas been compared with those of Beddoes. One reason for the lack of attention to such questions may well have been the insistence of the protagonists themselves that theory had no place in their fact-based enterprise. They have been taken literally by most historians.104... 

Cheng, J. Davis, M.E. Khin, K.T. Cyclodextrin-Based Polymers for Therapeutics Delivery. US Patent 20040077595 Al, Apr 22, 2004 Insert Therapeutics, Inc. Pasadena, CA. Allemann, E. Gurny, R. Doelker, E. Drug-loaded nanoparticles—preparation methods and drug targeting issues. Eur. J. Pharm. Biopharm. 1993, 39, 173-191. 

McPherson DD, Huang S, Holland CK (2008) Echogenic liposomes for molecular targeted therapeutic delivery. J Ac oust Soc Am 123 3216... 

Appropriate cellular adhesion, endocytosis, and intracellular trafficking to allow therapeutic delivery or imaging in the cytoplasm or nucleus. 

Application of SCF is now the subject of increasing interest especially in the pharmaceutical industry and there are three aims increasing bioavailability of poorly soluble molecules designing sustained-release formulations and formulation of active agents for new types of drug delivery that are less invasive than parental delivery (oral, pulmonary, transdermal). The most complex challenge is related to therapeutic delivery, as it is extremely difficult to obtain a satisfactory therapeutic delivery effect due to biomolecule instability and very short half-life in vivo. 

A second burgeoning area of application of mesoporous materials is in medically related areas for drug delivery, DNA transfection, and cell culture. The relative biocompatibility of silica, and the gradual dissolution of silica under physiological conditions lends itself to encapsulation for therapeutic delivery purposes. Mesoporous silica nanoparti-... 

The utilization of prepackaged diazepam for intramuscular use is a poor parenteral therapeutic delivery technique for this anticonvulsant. The diazepam is dissolved in propylene glycol and is poorly and erratically absorbed following intramuscular use. Although the intramuscular route is considered to be the least effective route for seizure control, lorazepam can be used intramuscularly and could be preferred to diazepam for EMS and Hazmat use. Lorazepam, however, has several disadvantages. From a financial perspective it is more expensive than diazepam. Lorazepam is not stable at high temperatures and therefore cannot be as easily stored as diazepam. Finally, without preloaded syringes or... 

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