National Institute of Bioscience and

PERM acronym derived from the former name of the Fermentation Research Institute (FRI), in Japan, which later became the Patent Microorganism Depository of the National Institute of Bioscience and Human Technology (NIBH). As previously mentioned, the Budapest Treaty requires deposition of the biological material subject to a patent application. In Japan and some other countries, an applicant for a patent concerning a microorganism has to submit a receipt of that deposition to the Patent Office at filing. The depository checks viability and would furnish a sample of the microorganism to a third party only for study and research, under the established rules of the treaty. 

Fig. 14.27. Typical STM image of the 4,4 -PySSPy on an Au(111) surface. (This picture was taken with the aid of Dr. Takahito Sawaguchi of the National Institute of Bioscience and Human Technology. (Reprinted from I. Taniguchi, Probing Metalloprotiens and Bioelectochemical Systems, Interfacial6(4) 34-37, Fig. 2, 1997. Reproduced by permission of The Electrochemical Society, Inc.)...

NIBH, National Institute of Bioscience and Human Technology Ministry of International Trade and Industry 1-3, Higashi, 1-Chome... 

National Institute of Bioscience and Human-Technology, AIST/MITI, Higashi 1-1, Tsukuba, Ibaraki, 305 Japan... 

Boehringer Mannheim Corporation, 47 City University of New York, 124,169 Colorado State University, 158 Delft University of Technology, 34 Eli Lilly and Company, 84 Firestone Building Products Company, 2 Georgetown University, 252 Kumamoto University School of Medicine, 194 Kyushu University, 238 National Institute of Bioscience and Human Technology, 41 National Tsing Hua University, 276 Naval Research Laboratory, 252,264 Polytechnic University, 124,169... 

Inspired by this work (24), we used Bayesian methods (24) with molecular function class fingerprints of maximum diameter 6 (53) to identify substructures that were shown to be important in recent TB screening datasets (21-23). Bayesian models were built with the previously described Molecular Libraries Small Molecule Repository (MLSMR) 220,463 library (4,096 active compounds) (15) and dose-response data using 2,273 molecules (475 active compounds). In addition, these models were tested (15) with the National Institute of Allergy and Infectious Diseases (NIAID) data and GVK Biosciences (Hyderabad, India) datasets used by Prathipati et al. (24). We have validated the models with compounds left out of the original models, in some cases showing up to tenfold enrichments in finding active compounds in the top-ranked 600 molecules (22). 

H SUZUKI, Y SATO, N OHBA Bioscience Division, Olympus Co., Tokyo 192-8512, Japan National Institute of Vegetables and Tea Science, Shizuoka 428-8501, Japan Yokosuka City Museum, Kanagawa 238-0016, Japan Email hirobumi2 suzuki ot.olympus.co.jp... 

Acknowledgement We acknowledge the financial support of National Science Foundation (CBET-0652073) and the Rice University Institute of Biosciences and Bioengineeiing Medictil Innovations Award. 

Institute for Bioscience and Biotechnology Research, BioProcess Measurements Group, Biomolecular Measurement Division, National Institute of Standards and Technology (NIST), Rockville, MD, USA Bioanalytical and Discovery Analytical Sciences, Research and Development, Bristol-Myers Squibb Company, Princeton, NJ, USA... 

Institute for Bioscience and Biotechnology Research, BioProcess Measurements Group, Biomolecular Measurement Division National Institute of Standards and Technology (NIST)... 

School of Nano-Bioscience and Chemical Engineering, KIER-UNIST Advanced Center for Energy and Low Dimensional Carbon Materials Center, Ulsan National Institute of Science and Technology (UNIST), UNIST-gil 50, Ulsan 689-798, Republic of Korea e-mail shjoo unist.ac.kr... 

The Author thanks Professor Allen P. Mills, Jr., of the University of California at Riverside Drs. R. Suzuki and T. Ohdaira of the National Institute of Advanced Industrial Science and Technology, Japan Dr. Shu Yang of Bell Labs Dr. J. Maxam of Oak Ridge National Laboratories and Professor D. Gidley of the University of Michigan for their contribution and helpful discussions. This research was sponsored by the Division of Chemical Sciences, Geosciences, and Biosciences, BES, U.S. DOE, under... 

Annette G. Beck-Sickinger Institute of Biochemistry, Faculty of Biosciences, Pharmacy, and Psychology, University of Leipzig, Leipzig, Germany Joanne T. Blanchfield School of Molecular and Microbial Sciences, University of Queensland, St. Lucia, Queensland, Australia Gregory T. Bourne Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland, Australia Terrence R. Burke, Jr. Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD... 

Acknowledgements Support from the National Institutes of Health (DK075936 to L.P.J. and DK079008 to J.A.H.), from the University of Arkansas for Medical Sciences, from the Arkansas Children s Hospital Research Institute, and from the Arkansas Biosciences Institute, the major research component of the Arkansas Tobacco Settlement Proceeds Act of 2000 is gratefully acknowledged. 

Acknowledgments This work was supported by the US National Science Foundation under Grant number CFlE-1213870. It was also supported by the National Institutes of Health under grant number GM103450, the Arkansas Biosciences Institute, and the Mildred B. Cooper Chair in Bioinformatics and Computational Research at the University of Arkansas. We acknowledge the resources of the Arkansas High Performance Computing Center. 

CDS Collection of the Centro de Desenvolvimento Biotecnologico, Brazil, A7CC The American Type Culture Collection, /TO The Institute for Fermentation, Osaka, HUTJhe Hiroshima University Type Culture Collection, P200910, P20, etc., strains from Iowa State University Collection, lAM Collection of the Institute of Applied Microbiology (now Institute of Molecular and Cellular Biosciences), Tokyo University, CIP Culture Collection of the Institut Pasteur, CNRZ Institut National de la Recherche Agronomique, and 52/ Strain isolated at Slovak Technical Institute, Bratislava... 

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India Institut national de la recherche scientihque Centre - Eau Terre Environnement (INRS-ETE), Quebec, Canada... 

Professor ChulHee Kang received his B.Sc. (physics and microhiology, 1980) and M.S. (microbiology, 1982) from Seoul National University and his Ph.D. (biophysics, 1987) from the University of California, Berkeley. He then pursued his postdoctoral studies at the Lawrence Berkeley National Laboratory (1988—89) with Dr. Sun-Hou Kim and at the Massachusetts Institute of Technology (1989-92) with Dr. Alexander Rich. After 2 years as a research scientist in the Department of Biology at MIT, he became an assistant professor (1994—99), associate professor (1999-2002), and the Edward Meier Distinguished Professor of Biophysics (2002-present) in the School of Molecular Biosciences at Washington State University. 

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