Nasopharyngeal tumor

Informed consent is obtained from all patient. Prior to LITT treatment all patients undergo CT and a contrast-enhanced MRI study at least 2 days prior to the intervention. After localization of the tumor with CT local anesthesia was achieved with 20-30 ml of 1% mepivacaine (Scandicain, AstraZeneca, Wedel, Germany). Distance to the lesion and the puncture angle are calculated electronically. For targeting of both recurrent nasopharyngeal tumors and pleomorphic adenomas a subzygomatic approach to the lesion was chosen, which provided the best and safest access to the lesion. Lesions of the larynx and the floor of the mouth were punctured directly. After the procedure the needle track was closed with flbrin glue (Tissucol Duo S, Baxter, Vienna, Austria). 

Vogl TJ, Mack MG, Muller P, Phillip C et al (1995) Recurrent nasopharyngeal tumors preliminary clinical results with interventional MR imaging-controlled laser-induced thermotherapy. Radiology 196 725 Vogl TJ, Mack MG, Hirsch HH, Muller P, Weinhold N, Wust P, Philipp C, Roggan R, Felix R (1997) In-vitro evaluation of MR-thermometry for laser-induced thermotherapy. Fortschr R5ntgenstr 167 638... 

Twenty-five cryptophycins, e.g. cryptophycin 1 (162), have been isolated from a Nostoc sp. strain. They exhibit various degrees of cytotoxicity against three tumor cell lines, namely KB (human nasopharyngeal), LoVo (human colorectal adenocarcenoma), and SKOV3 (human ovarian carcinoma). Removal of the chlorine atom leads to a 10-fold reduction in cytotoxicity [124]. The antitumor activity of a number of cryptophycins from Nostoc sp. has been evaluated [125]. 

Ansamycin antibiotics are probably the most complex organic compounds produced by the genus Streptomyces. In addition to the antibacterial, they also exhibit antiviral effects. Ansamitocin P-3 shows a potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. The compound exhibits a significant activity against P-388 lymphocytic leukemia in mice and both 9PS (murine lymphocytic leukemia) and 9KB (human nasopharyngeal carcinoma) in cell culture systems. [38]. 

Other studies have shown that S. miltiorrhiza exerts clear cytotoxic effects and strongly inhibits the proliferation of liver cancer cells (79). Various tanshinones were tested in SAR studies against several human tumor cells, namely nasopharyngeal... 

In a study by Roush et al. (1987), tlie potential for mortality from nasopharyngeal cancer and sinonasal cancer associated with occupational exposure to formaldehyde was investigated. Cases of nasopharyngeal and sinonasal cancer were identified through the Connecticut Tumor Registry the list was restricted to males with these cancers who died in Connecticut during the period 1935-1975. 

ISH EBV Nasopharyngeal carcinomas, lymphomas (Burkitt, Hodgkin, some T-cell lymphomas), subset of gastric cancers, immunodeficiency associated tumors... 

CK, cytokeratin EMA, epithelial membrane antigen LCA, leukocyte common antigen NPC, nasopharyngeal carcinoma ONE, olfactory neuroblastoma ES/PNET, Ewing s sarcoma/peripheral neuroectodermal tumor SNUC, sinonasal undifferentiated carcinoma. 

DLBCL, solitary fibrous tumor, synovial sarcoma, Kaposiform hemangiosarcoma, neurofibroma, schwannoma, nasopharyngeal carcinoma, dermatofibrosarcoma protuberans, spindle cell lipoma, rhabdomyosarcoma Follicular lymphoma (interfollicular area), Burkitt s lymphoma... 

Although cancer cell lines are a valuable tool for the study of new antitumor agents, in vivo experiments must also be performed in order to verify their efficacy. Polyphenols were found to inhibit in vivo breast, prostate, skin, nasopharyngeal, colon or gastric tumor xenografts in athymic and severe immunodeficient mice, the DMBA-induced breast or colon carcinogenesis, and the development and progression of prostate cancer in the TRAMP model. 

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