Adenoma pleomorphic

Kazmierczak, B., B. Thode, S. Bartnitzke, J. Bullerdiek, and W. Schloot. 1992. Pleomorphic adenoma cells vary in their susceptibility to SV40 transformation depending on the initial karyotype. Genes Chromosomes Cancer 5(1) 35-9. 

Hirabayashi, S. 1999. Immunohistochemical detection of DNA topoisomerase type II a and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland. 7. Oral Pathol. Med. 25 131—136. 

Pleomorphic adenoma (PA) is the most common salivary gland tumor. It occurs in all age groups, affects females more often than males, and may arise in either a major or a minor salivary gland location. When it originates in a major salivary gland, it is always encapsulated. Those of minor salivary gland origin are not encapsulated. 

Myoepitheliomas should be distinguished from pleomorphic adenomas and other salivary gland neoplasms. But the differential diagnosis may also include non-salivary gland lesions, depending on the predominant cell type in the myoepithelioma. For example, spindle cell myoepitheliomas should be differentiated from leiomyomas, schwannomas, and other spindle cell lesions. 

TABLE 9.12 Differential Diagnosis of Pleomorphic Adenoma (PA), Polymorphous Low-Grade Adenocarcinoma (PLGA), and Adenoid Cystic Carcinoma (ACC) ... 

Prasad AR, Savera AT, Gown AM, et al. The myoepithelial im-munophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma. Arch Pathol Lab Med. 1999 123(9) 801-806. 

Urethral and periurethral gland adenocarcinoma (female) Villous adenoma and adenocarcinoma of the bladder Extramammary Paget disease of the male external genitalia Pleomorphic adenoma of the salivary glands (male) Carcinoma of the salivary glands (male)... 

Salivary gland tumors (myoepithelial adenoma/ carcinoma, basal cell adenoma/carcinoma, pleomorphic adenoma)... 

Benign pleomorphic adenoma of the lacrimal gland is a slow-growing tumor that displaces the eyeball inferiorly and medially. Cross-sectional imaging shows a well-delineating, encapsulating lesion... 

Informed consent is obtained from all patient. Prior to LITT treatment all patients undergo CT and a contrast-enhanced MRI study at least 2 days prior to the intervention. After localization of the tumor with CT local anesthesia was achieved with 20-30 ml of 1% mepivacaine (Scandicain, AstraZeneca, Wedel, Germany). Distance to the lesion and the puncture angle are calculated electronically. For targeting of both recurrent nasopharyngeal tumors and pleomorphic adenomas a subzygomatic approach to the lesion was chosen, which provided the best and safest access to the lesion. Lesions of the larynx and the floor of the mouth were punctured directly. After the procedure the needle track was closed with flbrin glue (Tissucol Duo S, Baxter, Vienna, Austria). 

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