Nanoparticles receptors

Fischer NO, Verma A, Goodman CM, Simard JM, Rotello VM. Reversible irreversible inhibition of chymotrypsin using nanoparticle receptors. J Am Chem Soc 2003 125 13387-13391. 

Verma A Rotello VM, Surface recognition of biomacromolecules using nanoparticle receptors, Chem. Commun., 2005, 303-312. 

Fig. 3 Multifunctional nanoparticle receptor units recognize the proper target polyethylene glycol (PEG) chains improve the particle stability fluorophores provide a means for detection drug can be hosted inside...

Fig. 15 Versatifity of silica nanoparticles receptor units on the surface recognize their analytes fluorophores may undergo energy transfer processes drug can be hosted inside...

Bates et al. reported the construction and characterization of a gold nanoparticle wire assembled using Mg -dependent RNA-RNA interactions for the future assembly of practical nanocircuits [31]. They used magnesium ion-mediated RNA-RNA loop-receptor interactions, in conjunction with 15 nm or 30 nm gold nanoclusters derivatized with DNA to prepare self-assembled nanowires. A wire was deposited between lithographically fabricated nanoelectrodes and exhibited non-linear activated conduction by electron hopping at 150-300 K (Figure 16). 

Tamayo I, Irache JM, Mansilla C et al (2010) Poly(anhydride) nanoparticles act as active Thl adjuvants through Toll-like receptor exploitation. Clin Vaccine Immunol 17 1356-1362... 

Hamasaki T, Uto TA et al (2010) Modulation of gene expression related to Toll-like receptor signaling in dendritic cells by poly(y-glutamic acid) nanoparticles. Clin Vaccine Immunol 17 748-756... 

Hamdy S, Elamanchili P, Alshamsan A et al (2007) Enhanced antigen-specific primary CD4+ and CD8+ responses by codelivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid A in poly(D, L-lactic-co-glycolic acid) nanoparticles. J Biomed Mater Res A 81 652-662... 

Hamdy S, Molavi O, Ma Z et al (2008) Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity. Vaccine 26 5046-5057... 

Carbohydrates not only interact with protein receptors, but also with other carbohydrates and nucleic acids. Recently, gold nanoparticles (GNPs) have been prepared as new multivalent tools that mimic carbohydrate presentation on the cell surface. Using this tool, a weak calcium-mediated carbohydrate-carbohydrate interaction has been detected using NMR, employing... 

Fig. 32 Effect of analyte coordination in (a) a traditional molecular chemosensor system, (b) receptors wired in series in a conjugated polymer, (c) chemosensors grafted onto the surface of a nanoparticle, and (d) a fluorescent dendrimer. The curved arrows indicate the active...

Based on well established silica chemistry, the surface of silica nanomaterials can be modified to introduce a variety of functionalizations [3, 11, 118]. The toxicity of surface-modified nanomaterials is largely determined by their surface functional groups. As an example, Kreuter reported that an apolipoprotein coating on silica nanoparticles aided their endocytosis in brain capillaries through the LDL-receptor [122-124]. Overall, silica nanomaterials are low-toxicity materials, although their toxicity can be altered by surface modifications. 

Lochner, N., Pittner, F., Wirth, M., Gabor, F., Wheat germ agglutinin binds to the epidermal growth factor-receptor of artificial Caco-2 membranes as detected by silver nanoparticle enhanced fluorescence. Pharm Res 20, 833-839 (2003). 

Stevens PJ, Sekido M, Lee RJ. A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug. Pharm Res 2004 21 2153. 

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