Mimics, carbohydrate

Carbohydrate mimics, concepts and methods, Wiley-VCH, Weinheim, 1998, pp. 385 115. 

More recently, a similar transformation was used for the preparation of the nitro sugar derivative 32, a precursor of a carbohydrate mimic of 2-deoxystreptamine (Scheme 12).33... 

The limit of this modification lies on the impossibility to mime the anomeric substituent, which makes these compounds not really useful as carbohydrate mimics. 

The term glycal is used to define sugar derivatives having a double bond between C-1 and C-2. Accordingly, C-1 glycals are A1,2 unsaturated carbohydrate derivatives with a carbon substituent at the anomeric position. These compounds are versatile synthetic intermediates, owing to the variety of transformations associated with their enol ether functionality, and have found ample use in the preparation of C-glycosyl compounds,1 carbohydrate mimics,2 and natural products.3... 

A different strategy for the development of carbohydrate mimics has focused on the replacement of the non-pharmacophoric parts of active oligosaccharides by conformationally stable cyclic diols. Thus, looking for an analogue of the a-o-Man/)-(l — 2)-a-D-Man/>-(l — 6)-a-D-Man/)-mannotrioside, one of the terminal arms of the MangGlcNAc2... 

Zanini D, Roy R. Architectonic neoglycoconjugates effects of shapes and valences in multiple carbohydrate-protein interactions. In Chapleur Y, editor. Carbohydrate mimics. Weinheim Wiley-VCH 1998a. pp. 385-415. 

Wessel HP, Chucholowski A, Fingerle J, Iberg N, Marki HP, Muller R, Pech M, Pfister-Downar M, Rouge M, Schmid G, Tschopp T (1996) From glycosaminoglycans to heparinoid mimetics with antiproliferative activity. In Chapleur Y (ed) Carbohydrate mimics concepts and methods. Verlag Chemie, Weinheim, in press... 

Professor Nikolaos G. Argyropoulos was born in 1943. He received his B.Sc. in chemistry at Aristotle University of Thessaloniki (1968) and his Ph.D. at the same university, under the supervision of Professor N. E. Alexandrou. He worked as a postdoctoral research associate in the laboratory of R. Breslow at Columbia University (1980-81), and after that he returned to the Aristotle University of Thessaloniki where he become assistant professor (1985) and associate professor (1991). Since then, he is a permanent faculty member of the Aristotle University of Thessaloniki. His research interests are focused on heterocyclic synthesis and the synthesis of carbohydrate mimics, especially aza sugar derivatives as possible bioactive compounds. He was author of the chapter l,4-(Oxa/thia)-2-azoles in CHEC-II(1996). He is also the author of four relevant chapters that appeared in Science of Synthesis (vol. 13) dealing with all possible heteroaromatic (oxa/thia)-azoles. 

Carbohydrate Mimics Concepts and Methods, Chapleur, Y. Ed. Wiley-VCH. New York, NY, 1998. 

Ogawa S (1988) Synthetic studies on glycosidase inhibitors composed of 5a-carba-sugars. In Chapleur Y (ed) Carbohydrate mimics, concepts and methods. Wiley-VCH, Weinheim, pp 87... 

In the chemical synthesis of complex natural products, the concept of bidirectional chain synthesis has also been shown effective for the bi-directional backbone extension, as implemented by DHAP-dependent aldolases.37 As such, highly complex carbohydrate mimics may be obtained in a single pot... 

Combinatorial Chemistry for the Synthesis of Carbohydrate/Carbohydrate Mimics Libraries... 

Because of the complex nature of carbohydrates, interest in combinatorial approaches to obtain carbohydrate mimics has grown in recent years. By applying combinatorial strategies, the... 

To summarize, several groups are currently involved in developing combinatorial approaches for carbohydrates and carbohydrate mimics. This is a relatively new area of research and its impact towards understanding the biological function of carbohydrates will be seen in coming years. 

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