Nakanishi studies

Nakanishi studied philanthotoxin (polyamine-amide) interaction with nicotinic acetylcholine ion-channel [58]. Philanthotoxin-133 (PhTX-133) is a noncompetitive channel-blocker found in venom of the wasp Philanthus. Nicotinic acetylcholine ion-channel is composed of five transmembrane subunits (a, o, P, y, and S), which forms a 270-kDa glycoprotein. The major acetylcholine binding sites are in the a,ex subunits. A 43-kDa cytoplasmic protein is associated non-covalently with the receptor, but interaction with the receptor is not essential for the channel opening (Fig. 6). 

Yamada, Y., S. Suzuki, K. Iguchi, H. Kikuchi, Y. Tsukitani, H. Horiai, and H. Nakanishi Studies on Marine Natural Products. II. New Polyhydroxylated Sterols from the Soft Coral Lobophytum pauciflorum (Ehrenberg). Chem. Pharm. Bull. (Japan) 28, 473 (1980). 

The isolation of four terpenes from the bitter principles of Ginkgo by Furukawa in 19326 marked an important advance in the quest for the identification of the active constituents of Ginkgo extracts. A second major milestone was reached in 1967 when Nakanishi and his group reported their extensive and brilliant studies which permitted the structures of these compounds to be fully defined.4 On the basis of spectroscopic data and chemical reactivity... 

Crystallographic study of 2,5-DSP and poly-2,5-DSP demonstrated that the polymerization proceeded with retention of the space group (Pbca) of the starting 2,5-DSP crystal (Sasada et al., 1971 Nakanishi et al., 1972a). The result was the first evidence of an organic reaction which proceeded in the crystal lattice. 

Oikawa, H., Masuhara, A., Kasai, H., Mitsui, X, Sekiguchi, T. and Nakanishi, H. (2004) Nanophotonics integrating photochemistry, optics and nano/bio materials studies, in Proceedings of the International Nanophotonics Symposium Handai, vol. 1 (eds H. Masuhara and S. Kawata), Elsevier Science, Amsterdam, pp. 205-224. 

Stromgaard K, Saito DR, Shindou H, Ishii S, Shimizu T and Nakanishi K (2002). Ginkgolide derivatives for photolabeling studies Preparation and pharmacological evaluation. Journal of Medicinal Chemistry, 45, 4038-4046. 

Okazaki, S. Nakanishi, K. Touhara, H., Monte Carlo studies on the hydrophobic hydration in dilute aqueous solutions on nonpolar molecules, J. Theor. Biol. 1979, 71, 2421-2429... 

The analysis of CD and absorption data has been used since 1974, mainly by Nakanishi and his coworkers, to study the structure of the rhodopsins, pigments involved in the mechanism of vision, and of their chromophores50. 

Nakanishi, J. Oka, T. (1998) The Importance of Risk-Benefit Analysis in Risk Management Decision Makings A Cast Study of a Mercury Pollution Prevention Measure in Japan. Paper presented to OECD Workshop, London. 

M. Nakanishi, M. Kobayashi, M. Tsuboi, C. Takasaki, and N. Tamiya, Electronic spectroscopy and deuteration kinetics of tyrosine and tryptophan residues An application to the study of erabutoxin b. Biochemistry 19, 3204-3208 (1980). 

Harada N, Nakanishi K, Exciton chirality method and its application to configurational and conformational studies of natural products, Accounts Chem Res 5 257-263, 1972. 

The basic studies dealing with the preparation of continuous porous silica materials date back to 1991 [76-78]. Two years later, Nakanishi and Saga applied for a patent describing the fabrication of monolithic silica rods for chromatographic application [79-81], whereas a second protocol for the preparation of continuous silica rods was independently filed by Merck KGaA in Germany [82]. 

CA030 Nakanishi, N., K. Nakamura, K. Nakajima, K. Suzuki, and K. Tatara. Coffee consumption and decreased serum gamma-glutamyltransferase a study of middle-aged Japanese men. EurJ Epidemiol 2000 16(5) 419-423. 

Oth Mullen Gilles Schroder Helv. Chim. Acta 1974, 57,1415 Nakanishi Yamamoto Tetrahedron Lett. 15174, 1803 Gunther Ulmen Tetrahedron 1974, 30, 3781. For deuterium nmr spectra see Poupko Zimmermann Luz J. Am. Chem. Soc. 1904, 106, 5391. For a crystal structure study, see Luger Buschmann McMullan Ruble Matias Jeffrey J. Am. Chem. Soc. 19 6,108. 7825. 

Both uracil and thymine deprotonate at N-l or N-3 325,326 (forms 34 and 35, respectively), as initially proposed by Nakanishi et al.32i on the basis of the UV study of anions of uracil and of its N-l- and N-3-methyl derivatives. 

Huang, X., Nakanishi, K., and Berova, N. 2000. Porphyrins and metalloporphyrins Versatile circular dichroic reporter groups for structural studies. Chirality 12 237-255. 

Ohishi H., Shigemoto R., Nakanishi S., and Mizuno N. (1993). Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain an in situ hybridization study. J. Comp. Neurol. 335 252-266. 

Nakanishi K (2000) Recent bioorganic studies on rhodopsin and visual transduction. Chem Pharm Bull 48, 1399-1409. 

Principles and Applications, VCH Publishers, New York-Weinheim 1994 H.R. Christen, F. Vogtle, Circular Dichroismus, in Organische Chemie, Von den Grundla-gen zur Forschung, Vol. II, Salle, Frankfurt am Main 1990, pp. 301-334 N. Har-ada, K. Nakanishi, Circular Dichroic Spectroscopy - Exciton Coupling in Organic Stereochemistry, Oxford University Press 1983 S.F. Mason, Optical Activity and Chiral Discrimination, Reidel, Dordrecht, Nato Advances Study Institutes Series, Series C, Vol. 48, 1978 E. Charney,... 

Nakanishi, H., Jones, W., Thomas, J. M., Hursthouse, M. B., Motevalli, M., Static and dynamic single-crystal X-ray-diffraction studies of some solid-state photo-dimerization reactions. J. Phys. Chem. 1981, 85, 3636-3642. 

Zacks, D. N., Derguini, F., Nakanishi, K., and Spudich, J. L., Comparative study of phototactic and photophobic receptor chromophore properties in Chlamydomonas reinhardtii, Biophy. J., 65, 508, 1993. 

Tatsuno, Y., Adachi, J., Mizoi, Y., Fujiwara, S., Nakanishi, K., Taniguchi, T., et al. (1986). Four cases of fatal poisoning by hydrogen sulphide A study of greenish discoloration of the skin and formation of sulfhemoglobin. Nippon Hoigaku. Zasshi. 40, 308-315. 

The study of natural products has attracted more attention from historians than any other aspect of organic chemistry. Many of the autobiographies mentioned earlier related to chemists who included natural product research as one of their main interests. In some cases it has been an all-consuming one, as in the case of K. Nakanishi.197 Many recent historical accounts apply to specific groups of organic compounds. 

K. Nakanishi, Past and present studies with ponasterones, the first insect molting hormones from plants , Steroids, 1992, 57, 649-657. 

CD studies of pyranosides derivatized as tribenzoates have shown that the pairwise couplings are additive. For example in the 2,3,4-tris-p-chlorobenzoate of methyl-a-D-manno-pyranoside there are three pairwise couplings (2,3), (3,4) and (2,4).[2] As shown in Figure 35, each of the three is predicted to exhibit a (-) exciton chirality, and thus (assuming additivity) the net CD is expected to correspond to a (-) exciton chirality. This is, in fact, observed. In other sugars, where some of the individual couplets may have a (+) exciton chirality, and others a (-) exciton chirality, the net predicted exciton CD would be determined by the magnitudes and signs of each of the component couplet CEs. Nakanishi et al have shown this approach to be exceptionally reliable. [37]... 

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