Oxidase, NADH

Inflammatory cell phenomenon are also contributors to lipid peroxidation. Activated neutrophils may adhere to damaged endothelium and amplify traumatic, ischaemic or ischaemia-reperfiision injury. Many cyclooxygenase products of the metabolism of atachidonic acid modulate the inflammatory responses of cells. Macrophages, neutrophils and microglia are important sources of reactive oxygen at the injury site. When activated, they produce a respiratory burst that is traced to activated nicotinamide adenine dinucleotide (NADPH/NADH) oxidase. [Pg.273]

They observed abrupt changes in the slope of Arrhenius plots for reactions catalyzed by NADH oxidase and p-lactate oxidase that correlate well with phase transitions detected by the ESR spectra of the nitroxide spin labels bound covalently to the enzymes (Table 5.4). [Pg.109]

NADH oxidase p-Lactate oxidase Phase trans. temp (°C)... [Pg.110]

Similar to the work described by Spohn et al. [34], a trienzyme sensor was developed recently for the determination of branched-chain amino acids (L-valine, L-leucine, and L-isoleucine). Leucine dehydrogenase, NADH oxidase, and peroxidase were coimmobilized covalently on tresylate-hydrophylic vinyl polymer beads and packed into a transparent PILL tube (20 cm X 1.0 id), which was used as flow cell. The sensor was free of interferences from protein and NH4+ and it was stable for 2 weeks. The sensor system was applied to the determination of branched-chain amino acids in plasma with recoveries ranging from 98 to 100% [36],... [Pg.577]

Sanders, S. A., Eisenthal, R., Harrison, R., NADH oxidase activity of human xanthine oxidoreductase Generation of superoxide anion. [Pg.51]

FprA alone had a low level of NADH oxidase activity with oxygen as a terminal electron acceptor. Addition of Hrb stimulates the oxidase activity of FprA, and NADH supported 10-fold higher oxidase activity than... [Pg.197]

Daidzein (114) Isoflavone Phenoxodiol (115) Oncology NADH oxidase (tNOX) and sphingosine-1-phosphate inhibition Phase III (ovarian cancer) Phase II (castrate and non-castrate prostate cancer) Marshall Edwards (Novogen) 703-707... [Pg.69]

Boron also appears to be involved in redox metabolism in cell membranes. Boron deficiency was shown to inhibit membrane H -ATPase isolated from plant roots, and H -ATPase-associated proton secretion is decreased in boron-deficient cell cultures [71]. Other studies show an effect of boron on membrane electron transport reactions and the stimulation of plasma reduced nicotinamide adenine dinucleotide (NADH) oxidase upon addition of boron to cell cultures [72, 73]. NADH oxidase in plasma membrane is believed to play a role in the reduction of ascorbate free radical to ascorbate [74]. One theory proposes that, by stimulating NADH oxidase to keep ascorbate reduced at the cell wall-membrane interface, the presence of boron is important in... [Pg.22]

In addition, cofactor engineering has been used to deliberately modify the intracellular NADH/NAD+ ratio that plays a predominant role in controlling the Lactococcus lactis fermentation pattern. The introduction of the nox gene, which codes for a NADH oxidase (NOX) that converts molecular oxygen to water at the expense of NADH, to a strain with an inactivated copy of the aldB gene for a-acetolactate decarboxylase led to the efficient metabolism of the na-... [Pg.624]

Nixon JE et al. (2002a) Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica. Eukaryot Cell 1 181-190 Nixon JE et al. (2002b) A spliceosomal intron in Giardia lamblia. Proc Natl Acad Sci USA 99 3701-3705... [Pg.70]

Two pyridine nucleotide-specific dehydrogenases are responsible for oxygen reduction in the cytosol a highly active NADH oxidase that reduces oxygen to water (Linstead and Bradley, 1988 Tanabe, 1979) and a minor NADPH oxidase that produces hydrogen peroxide (Linstead and Bradley 1988). [Pg.128]

Tanabe M (1979) Trichomonas vaginalis NADH oxidase activity. Exp Parasitol 48 135-143 Thong KW, Coombs Gfi (1987) Comparative study of ferredoxin-linked and oxygen-metabolizing enzymes of trichomonads. Comp Biochem Physiol 87 637-641 Helens ACM, Rotte C, van fiellemond JJ, Martin W (2002) Mitochondria as we don t know them. Trends Biochem Sci 27 564-572... [Pg.146]

Morre, D.J., Cabo, R.D., Farley, C., Oberlies, N.H., and McLaughlin, J.L. Mode of action of bullatacin, a potent new antitumor acetogenin inhibition of NADH oxidase activity of HELA and HL-60, but not liver plasma membranes. Life Sci.., 56, 343, 1995. [Pg.189]

NADH oxidase (Grufferty and Condon 1983). Not all lactic streptococci express these alternative pathways. However, these deficient strains grow poorly under conditions producing low nLDH activity. [Pg.666]

Coupling of a second enzyme reaction NAD(P)H+02->NADH oxidase NAD(P)++H20a->H202 monitoring [26] (For the particular case of lactate dehydrogenase, where pyruvate is one of the reaction products, pyruvate oxidase or pyruvate transaminase has been coupled to the main enzyme reaction) [23,27]... [Pg.259]

Leca and Marty [26] Cider Wine Whisky Co-immobilisation of alcohol dehydrogenase (ADH), NADH oxidase and high molecular weight NAD (NAD-dextran) in a poly(vinyl alcohol) bearing stryrylpyridinium groups (PVA-SbQ) matrix Pt/+550 vs. Pt ... [Pg.266]

B. R. Riebel, P. R. Gibbs, W. B. Wellborn, and A. S. Bommarius, Cofador regeneration of NAD+ from NADH novel water-forming NADH oxidases,... [Pg.242]

As an example, a protein sequence of a bacterial NADH oxidase, in this case the protein sequence of a water-forming NADH oxidase from Streptococcus mutans, is submitted to a blastp search ... [Pg.423]

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