Trichomonas vaginalis

The identification of IscS homologues in the genome of T. vaginalis and G. intestinalis indicates that systems analogous to that operating in animals and fungi are conserved in these anaerobic organisms (Tachezy et al. 2001). 

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G Wu, A Eiser, B ter Kuile, A Sail, M Muller. Convergent evolution of Trichomonas vaginalis lactate dehydrogenase from malate dehydrogenase. Proc Natl Acad Sci USA 96 6285-6290, 1999. 

Some of the 7-alkylamiiio- and arylamino-substituted derivatives of l-ethyl-l,4-dihydro-6-iiitro-4-oxo-l,8-iiaphthyridiiie-3-ethylcarboxylate showed nearly the same antibacterial activity as metronidazole against Trichomonas vaginalis (77MI2 79YZ155). 

Trichomonas vaginalis is a ubiquitous sexually transmitted anaerobic flagellate causing vaginitis in women and prostate gland infection in men. 

Trichomonas Vaginalis Tricyclic Antidepressants Triiodothyronine 3, 5,3-L-Triiodothyronine... 

Trichomoniasis is caused by the protozoan Trichomonas vaginalis and is far more prevalent than C. trachomatis or N. gon-orrhoeae. In the United States, it is estimated that 5 million new cases appear annually, compared with 3 million chlamydial and 650,000 gonococcal cases annually.16... 

National Guidelines for the management of Trichomonas vaginalis. Sex Transm Inf 1999 75(Suppl 1) S21-S23. 

While nitrofurans are often prepared as antibacterial agents, nitroimidazole forms the basis for an extensive class of agents used in the treatment of infections by the protozoans. Unlike bacterial infections, protozoal infections are seldom life-threatening. The physical discomfort occasioned by such infections is, however, of sufficient importance to provide a useful therapeutic place for antiprotozoal agents. A particularly common set of such conditions are parasitic infections of the genitalia caused by Trichomonas vaginalis. These disorders are called trichomoniasis. 

Urine specimens usually are examined for the eggs of Schistosoma haemotobium or the trophozoites of Trichomonas vaginalis, although occasionally the larvae of Strongyloides stercoralis may be found in patients with hyperinfection syndrome. Urine is the usual specimen for the diagnosis of Trichomonas infection in males. See below (Vaginal Material) for culture method. Urine is centrifuged, and the sediment is examined microscopically. 

Chlamydia trachomatis, herpes simplex virus, Neisseria gonorrhoeae, Trichomonas vaginalis, Ureaplasma urealyticum C trachomatis, N. gonorrhoeae... 

Trichomoniasis is caused by Trichomonas vaginalis, a flagellated, motile protozoan that is responsible for 3 million to 5 million cases per year in the United States. 

Chapman A, Cammack R, Linstead D, Lloyd D. 1985. The generation of metronidazole radicals in hydrogenosomes isolated from Trichomonas vaginalis. J Gen Microbiol 131 2141-4. 

Chapman A, Cammack R, Linstead DJ, Lloyd D. 1986. Respiration of Trichomonas vaginalis components detected by electron paramagnetic resonance spectroscopy. Eur J Biochem 156 193-8. 

Kulda J, Tachezy J, Cerkasovova A. 1993. In vitro induced anaerobic resistance to meteronidazole in Trichomonas vaginalis. J Eukary Microbiol 40 262-9. 

Payne Ml, Chapman A, Cammack R. 1993. Evidence for an [Fe]-type hydrogenase in the parasitic protozoan Trichomonas vaginalis. Febs Lett 317 101-4. 

Rasoloson D,Tomkova E, Cammack R, et al. 2001. Metronidazole-resistant strains of Trichomonas vaginalis display increased susceptibility to oxygen. Parasitology 123 45-56. 

Rasoloson D, Vanacova S,Tomkova E, et al. 2002. Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis. Microbiol Mol Biol Rev 148 2467-77. 

Tachezy J, Sanchez LB, Muller M. 2001. Mitochondrial type iron-sulfur cluster assembly in the amitochondriate eukaryotes Trichomonas vaginalis and Giardia intestinalis, as indicated by the phylogeny of IscS. Mol Biol Evo 18 1919-28. 

Giardiasis For the treatment of giardiasis caused by Giardia duodenalis (also termed Giardia lamblia) in adults and pediatric patients older than 3 years of age. Trichomoniasis For the treatment of trichomoniasis caused by Trichomonas vaginalis in female and male patients. Because trichomoniasis is a sexually transmitted disease with potentially serious sequelae, partners of infected patients should be treated simultaneously in order to prevent reinfection. 

Trichomoniasis is a genital infection produced by the protozoan Trichomonas vaginalis. Infections frequently are asymptomatic in the male, whereas in the female vaginitis characterized by a frothy pale yellow discharge is common. Relapses occur if the infected person s sexual partner is not treated simultaneously. 

Antiparasitic activity. Oleo-gum resin from roots and stems was active on Trichomonas vaginalis ... 

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