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N-trimethyl-chitosan

Kotze AF, Leeuw BJ, Luessen HL, Boer AG, Verhoef JC, Junginger HE (1998) Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Control Release 51 35—46. [Pg.210]

Thanou, M., Florea, B.I., Langermeyer, M.W.E., Verhoef, J.C., and Junginger, H.E., N-Trimethylated chitosan chloride (TMC) improves the intestinal permeation of the peptide drug buserelin in vitro (Caco-2 cells) and in vivo (rats), Pharm. Res., 17 27-31 (2000). [Pg.192]

In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers. Pharmaceutical Research, 22, 38-49. [Pg.138]

Fig. 6.4 Chemical structure of (a) chitosan and (b) N-trimethyl chitosan chloride (from Kotze et al. 1998)... Fig. 6.4 Chemical structure of (a) chitosan and (b) N-trimethyl chitosan chloride (from Kotze et al. 1998)...
N-Trimethyl Chitosan as Absorption Enhancer of Peptide Drugs... [Pg.111]

Thanou M, Verhoef JC, Marbach P, Junginger HE Intestinal absorption of octreotide N-trimethyl chitosan chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo, J Pharm Sci 2000, 89, 951. [Pg.1389]

N, N, N -trimethyl chitosan chloride (TMC) Fig. 2 General synthesis of W,AiV-trimethyl chitosan chloride... [Pg.23]

Thanou MM, Kotze AF et al (2000) Effect of degree of quatemlzatlon of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers. J Control Release 64 15-25... [Pg.38]

Verheul RJ, Amidi M et al (2008) Synthesis, characterization and in vitro biological properties of O-methyl free N, N, N-trimethylated chitosan. Biomaterials 29 3642-3649... [Pg.38]

Sieval AB, Thanou M et al (1998) Preparation and NMR characterization of highly substituted N-trimethyl chitosan chloride. Carbohydr Polym 36 157-165... [Pg.39]

Varkouhi AK, Verheul RJ et al (2010) Gene silencing activity of siRNA polyplexes based on thiolated N, N, N-trimethylated chitosan. Bioconjug Chem 21 2339-2346... [Pg.39]

Zhang C, Ding Y et al (2007) Polymeric micelle systems of hydroxycamptothecin based on amphiphilic N-alkyl-N-trimethyl chitosan derivatives. Colloids Surf B 55 192-199... [Pg.39]

Keely, S. Rullay, A. Wilson, C. Carmichael, A. Carrington, S. Corfleld, A. Haddleton, D.M. Brayden, D.J. In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly methacrylate and N-trimethylated chitosan polymers. Pharm. Res. 2005, 22 (1), 38-49. [Pg.1251]

Sliitter, B. Jiskoot, W. Dual role of CpG as immune modulator and physical cross linker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination. 7. Contr. Release 2010,148 (1), 117-121. [Pg.1270]

Amidi, M., Romeijn, S. G., Coos Verhoef, f., Junginger, H. E., Bungener, L., Huckriede, A., Crommelin, D. J. A., and Jiskoot, W. (2007). N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination Biological properties and immunogenicity in a mouse model. Vaccine, 25,144-153. [Pg.548]

Sandri,G., Bonferoni, M.C.,Rossi,S.,Ferrari, F., Boselli, C.,andCaramella,C. (2010). Insulin-loaded nanoparticles based on N-trimethyl chitosan In vitro (caco-2 model) and ex vivo (excised rat jejunum, duodenum, and ileum) evaluation, AAPS P/iarmSczTec/i, 11(1), 362-371. [Pg.552]

Hamman, J. H., Stander, M., Kotze, A. F., Monti, D., Chetoni, P. J. (2002). Effect of degree of quaternization of N-trimethyl chitosan chloride on absorption enhancement In vivo evaluation in rat nasal epithelia,... [Pg.577]

Kotze, A.F., Hamman, J.H., Snyman, D. et al. (2002) Mucoadhesive and absorption enhancing properties of N-trimethyl chitosan chloride, in Chitosan in Pharmacy and Chemistry (eds R.A.A. Muzzarelli and C. Muzzarelli), ATEC, Grottammare, Italy, pp. 31-40. [Pg.86]

Quaternized chitosan was developed by the reaction of chitosan with methyl iodide under basic conditions. After quaternization, the obtained N,N,N-trimethyl chitosan chloride (TMC) was soluble at neutral pH. The TMC makes it possible to prepare gene polyplexes over a wide pH range compared with the unmodified chitosan. The protonation of the amino group was pH independent when it was trimethylated, which favored the solubility of chitosan derivatives at physiological pH and the formation of polyplexes with DNA and siRNA. The presence of more positive charges contributed to better colloidal stability arising from both electrostatic stabilization and static effects. The size of the gene polyplexes obtained with trimethyl chitosan was reduced when compared with those formed with the... [Pg.574]

Chen, F., Zhang, Z.R., Yuan, F., Qin, X., Wang, M., and Huang, Y. 2008a. In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery. Int. J. Pharm. 349 226-233. [Pg.354]

A.F. Kotze, H.L. Luessen, B.J. De Leeuw, B.G. De Boer, J.C. Verhoef, H.E. Junginger, N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces in vitro evaluation in intestinal epithelial cells (Caco-2), Pharmaceutical Research 14... [Pg.310]

M. Amidi, S.G. Romeijn, G. Borchard, H.E. Junginger, W.E. Hennink, W. JiskooL Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. Journal of Controlled Release 111 (2006) 107-116. [Pg.310]

Nasal delivered antigenic mncoadhesive nanoparticles, made up of N-trimethyl chitosan crosslinked (TMC) with tripolyphosphate (TPP) has been confirmed to overcome certain obstacles faced during nasal delivery such as poor absorption and... [Pg.65]

Functionalization and derivatization of chitosan is known to be the most reliable alternative for modifying its physico-chemical and biological properties. Recently N,N,N-trimethyl chitosan nanoparticles has explored as a vitamin carrier system whereas N-Acylated chitosan stabilized iron oxide nanoparticles has proven as a novel nano-matrix for ceramic modification [120, 121]. Similarly various other... [Pg.71]

N-trimethyl chitosan (TMC) and N-diethylmethylchitosan (DEMC) NPs For insulin deUvery [190]... [Pg.77]

N,N,N-Trimethyl chitosan NPs For controlled intranasal delivery of HBV surface antigen [192]... [Pg.77]

See other pages where N-trimethyl-chitosan is mentioned: [Pg.160]    [Pg.108]    [Pg.110]    [Pg.194]    [Pg.583]    [Pg.1252]    [Pg.584]    [Pg.75]    [Pg.561]    [Pg.342]    [Pg.343]    [Pg.356]    [Pg.105]    [Pg.66]    [Pg.67]    [Pg.68]    [Pg.68]    [Pg.72]   
See also in sourсe #XX -- [ Pg.159 ]



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