N-methyl D-aspartate

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. [Pg.16]

Cruz SE, Mirshahi T, Thomas B, et al Effects of the abused solvent toluene on recombinant N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 286 334-340, 1998 De Rosa E, Bartolucci GB, Sigon M, et al Hippuric acid and ortho-cresol as biological indicators ofoccupational exposure to toluene. Am J Ind Med 11 529—537,1987 Delteil P, Stoesser F, Stoesser R L theromanie. Ann Med Psychol (Paris) 1 329-340, 1974... [Pg.305]

Bachis A, Mocchetti I (2004) The chemokine receptor CXCR4 and not the N-methyl-D-aspartate receptor mediates gpl20 neurotoxicity in cerebellar granule cells. J Neurosci Res 75(1) 75-82... [Pg.21]

Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, Freyssinet JM, Tardieu M (2004) Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci 20(12) ... [Pg.23]

Lynch DR, Guttmann RP (2002) Excitotoxicity perspectives based on N-methyl-D-aspartate receptor subtypes. J Pharmacol Exp Ther 300(3) 717-723 Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995) Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 37(3) 373-380 Mamdouh Z, Chen X, Kerini LM, Maxfield FR, Muller WA (2003) Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis. Nature 421(6924) 748-753... [Pg.27]

Pittalnga A, Pattarini R, Severi P, Raiteri M (1996) Hnman brain N-methyl-D-aspartate receptors regnlating noradrenaline release are positively modnlated by HIV-1 coat protein gpl20. Aids 10(5) 463 68... [Pg.29]

Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999) Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system. AIDS Res Hum Retroviruses 15(16) 1461-1467... [Pg.32]

Abbreviations N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), L(+)-2 amino-3-phosphonopropionic acid (L-AP3), 6-cyano-7-nitroqninoxaline (CNQ5Q, 2,3-dihydroxy-6-nitro-7-sulfamyl-benzo-f-quinoxaline (NBQX), 3-(2-carboxypiperazin-4-yl)-propyl-l-phosphonic acid (CPP), 7 Chlorokynnreic... [Pg.220]

Todoroki, N., Shibata, K., Yamada, T. Kera, Y., and Yamada, R. H., Determination of N-methyl-D-aspartate in tissues of bivalves by high-performance chromatography, /. Chromatogr. B, 728, 41, 1999. [Pg.306]

CIWA-Ar, Clinical Institute Withdrawal Assessment for Alcohol-Revised GABA, y-aminobutyric acid IV, intravenous NMDA, N-methyl D-aspartate. Br. J. Addict. 1989 84 1353-1357. [Pg.145]

Status epilepticus occurs because the brain fails to stop an isolated seizure. The exact reason for this failure is unknown and probably involves many mechanisms. A seizure is likely to occur due to a mismatch of excitatory and inhibitory neurotransmitters in the brain. The primary excitatory neurotransmitter in the brain is glutamate. Glutamate stimulates postsynaptic N-methyl-D-aspartate (NMDA) receptors in the brain, causing an influx of calcium into the cells and depolarization of the neuron. Sustained depolarization may maintain SE and eventually cause neuronal injury and death.7 The primary... [Pg.462]

Ach, acetylcholine CNS, central nervous system CD, carbidopa COMT, catechol-O-methyltransferase D1, a class of dopamine receptors which includes D, and D5 subtypes D2, a class of dopamine receptors which includes D2, D3, and D4 subtypes DA, dopamine LD, levodopa MAO, monoamine oxidase MD, maintenance dose NMDA, N-methyl-D-aspartate. [Pg.479]

The current gold standard of treatment for cognitive symptoms includes pharmacologic management with a cholinesterase inhibitor and/or an N-methyl-D-aspartate (NMDA) antagonist. [Pg.513]

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