Epithelial cancers

Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR. Epithelial cancer cell migration a role for chemokine receptors Cancer Res 2001 61 4961 -4965. 

Kukowska-Latallo, J.F., Candido, K.A., Cao, Z., Nigavekar, S.S., Majoros, I.J., Thomas, T.P., Balogh, L.P., Khan, M.K., and Baker Jr., J.R. (2005) Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res. 65(12), 5317-5324. 

Arts IC, Hollman PC, Bueno De Mesquita HB, Feskens EJ and Kromhout D. 2001. Dietary catechins and epithelial cancer incidence the Zutphen elderly study. Int J Cancer 92(2) 298-302. 

EGFR, unmutated Overexpression and autocrine stimulation Epithelial cancers, Psoriasis, Papilloma... 

Scallan, M.J., Raj, B.K.M., Calvo, B., Garin-Chesa, P., Sanz-Moncasi, M.P., Healey, J.H., Old, L.J. and Rettig, W.J. (1994) Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblast of epithelial cancers. Proceedings of the National Academy of Sciences ofthe United States of America, 91, 5657-5661. 

The importance of these types of investigations was emphasized because the consumption of foods with high carotenoid content may reduced the risk of lung and other epithelial cancers [40],... 

Nimotuzumab TheraCIM Humanized IgGl anti-EGE receptor Advanced head/neck epithelial cancer 2005 China... 

Arts, I.C.W. et al.. Dietary catechins and epithelial cancer incedence the Zutphen Elderly Study, Int. J. Cancer, 92, 298, 2001. 

Carrots, tomatoes, and dark green vegetables are rich in specific carotenoids. Numerous epidemiological studies have shown that the increased intake of fruits and vegetables is associated with a reduced risk of lung and other epithelial cancers. Accurate food composition data have been prepared to test the association between dietary intake of specific carotenoids and disease incidence (Table 63.1). 

Farley, J., Smith, L.M., Darcy, K.M., Sobel, E., O Connor, D., Henderson, B., Morrison, L.E., and Birrer, M.J. 2003. Cyclin E expression is a significant predictor of survival in advanced, sub-optimally debulked ovarian epithelial cancers A gynecologic oncology group study. Cancer Res. 

The difficult to collect Antarctic sponge, Kirkpatrickia variolosa, is the source of the cytotoxic variolins.300,301 The most active of which, variolin B 18 (Scheme 6.1 Part 2), has shown activity against herpes simplex type I and P388 leukaemia cells. Variolin B induced apoptosis in multidrug resistant leukaemia and epithelial cancer cell lines. Due to the difficulty of Antarctic collection, synthetic efforts have been pursued resulting in the partial synthesis of the tricyclic core of variolin B,306 310 three total syntheses of variolin B311 313 and the development of variolin derivatives.314 317... 

T. Takeuchi, M.A. Shuman, C.S. Craik, Reverse biochemistry use of macro-molecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. Proc. Natl. Acad. Sci. USA 1999, 96, 11054-11061. 

Fig. 12.12 With each cell division, the telomeies at the end of the chromosomes become shortened. The model shows that in order to stop senescence and death, both telomerase activity and blockage of the RB pathway are needed. Telomerase activity and blockage of the RB pathway are intimately linked, because the factors that block the RB pathway (the wyc oncogene and the E6 oncogene of the human papillomavirus, see Part 4) also upr late expression of hTERT.24 In contrast to normal differenbated cells, cancer cells have telomerase adivity. In this way, cancer cells overturn the life-sparvcontrolling clock and become immortal. Since, about 90% of all human cancers are derived from epithelial cells, it follows that in epithelial cancer cells the RB pathway has also been inactivated. To the contrary, when the tumour-suppressor p 53 accumulates, the cells age prematurely.25...

Zliao TM, Bryant MA, Kindt TJ, Simpson RM (2002) Monoclonally integrated HTLV type 1 in epithelial cancers fiom rabbits infected witli an HTLV type 1 molecular clone. AIDS Res Hum Retroviruses 18 253—258. 

---