Multiple sclerosis stem cell transplants

Stem cell transplantation to replenish glial cells lost in multiple sclerosis 512... 

Microchimerism and Stem Cell Transplantation in Multiple Sclerosis... 

Bind RK, Cohen BA, Russell E, Spero K, Joshi A, Oyama Y, Karpus WJ, Fuo K, Jovauic B, Traynor A, Karth K, Stefaski D, Bums WH (2003a) Haematopoietic stem cell transplantation for progressive multiple sclerosis failure of intense immune suppression to prevent disease progiession m patients with high disability scores. Blood 102 2373-2378. 

Kozak T, Havrdova E, Pitha I, Gregor a E, Oitlik R, Maaloufova I, Kobylka P, Vodrarkora S (2001) Immunoblative therapy with autologous stem cell transplantation in die treatment of poor risk multiple sclerosis. Transplant Proceed 33 2179—2181. 

Healey KM, Pavletic SZ, Al-Omaishi J, Leuschen MP, Pirrucello SJ, Eilipi ML, Enke C, Ursick MM, Hahn E, Bowen JD, Nash RA (2004) Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation. Mult Seer 10 284-289. 

Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation. Mult Scler 10 284-289. 

Openshaw H, Lund BT, Kashyap A, Atkinson R, Sniecinski I, Weiner LP, Forman S. Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning report of toxicity and immunological monitoring. Biol Blood Marrow Transplant 2000 6(5A) 563-75. 

Nash RA, Bowen JD, McSweeney PA, et al. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation in severe multiple sclerosis. Blood 2003 102 2364-2372. 

The use of neural stem cells in remyelinating therapy has been explored by many researchers. Pluchino et al. (2003) successfully used adult neural stem cells to promote functional recovery in a multiple sclerosis model. Transplanted neural stem cells showed the ability to selectively reach the demy-elinating areas, where they differentiated into axon-ensheathing oligodendrocytes and achieved extensive remyehnation (Pluchino et al., 2003). 

However those capsules are not limited to diabetes they have other applications with hepatocytes and stem cells. Applications of stem cells for therapy of neurological conditions, such as Parkinson s disease, Alzheimer s disease, multiple sclerosis, or stroke, are promissory therapies for the irreversible damage of the central nervous system produced in these cases. In that sense, the transplantation of stem cells into the mouse brain, and MRI of the cells both in vivo and post-mortem have been analyzed [87]. Also labeling of stem cells with superparamagnetic iron oxides (SPIOs) have been developed for using MRI to visualize these cells in myocardial infarct [88]. 

In other experience, it was proven that transplantation of intrathecal and intravenous administration of autologous mesenchymal stem cells (MSCs) (also called mesenchymal stromal cells) in patients with multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) is a clinically feasible and relatively safe procedure and induces immediate immimomodulatory effects [90]. 

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