Mouse skin carcinogenesis

Lee, J.-Y., Shin, J.-W., Chun, K.-S., Park, K.-K., Chung, W.-Y., Bang, Y.-J., Sung, J.-H., and Surh, Y.-J. (2005). Antitumor promotional effects of a novel intestinal bacterial metabolite (lH-901) derived from protopanaxadiol-type ginsenosides in mouse skin. Carcinogenesis 26, 359-367. 

Murakoshi, M., Nishino, H., Tokuda, H., Iwashima, A., Okuzumi, J., Kitano, H., and Iwasaki, R. (1992). Inhibition by squalene of the tumor promoting activity of 12 o-tetradecanoylphorbol-13 acetate in mouse skin carcinogenesis. Int. ]. Cancer 52,950-952. 

Patamalai, B., Burow, D.L., Gimenez-Conti, I., Zenklusen. J.C.. Conti, C.J.. Klein-Szanto, A.J. Fischer, S.M. (1994) Altered expression of transforming growth factor-pi inRNAand protein in mouse skin carcinogenesis. Mol. Carcinog., 9, 220-229... 

Phenol was tested for carcinogenicity by oral administration in rats in one study and in mice in one study. An increased incidence of leukaemia was reported in male rats treated with the lower dose but not in high-dose rats or in mice or female rats. Phenol was a promoter of mouse skin carcinogenesis in two-stage protocols. 

Haesen, S., Timmermans, M. Kirsch-Volders, M. (1993) Induction of micronuclei and karyotype aberrations during in vivo mouse skin carcinogenesis. Carcinogenesis, 14, 2319-2327... 

DiGiovanni J, Viaje A, Berry DL, et al. 1977. Tumor-initiating ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Arochlor 1254 in the two-stage system of mouse skin carcinogenesis. Bull Environ Contam Toxicol 18 552-556. 

Hennings, H., Blumberg, P. M., Pettit, G. R., Herald, C. L., Shores, R., and Yuspa, S. H., Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin, Carcinogenesis, 8, 1343, 1987. 

Diwan BA, Ward JM, Rice JM, et al. 1985. Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin Carcinogenesis 6 343-397. 

Chida, K., Murakami, A., Tagawa, T., Ikuta, T., and Kuroki, T., Cholesterol sulfate, a second messenger for the n isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis, Cancer Res., 55, 4865, 1995. 

Cavalieri E, Munhall A, Rogan E et al (1983) Syncarcinogenic effect of the environmental pollutants cyclopenteno[cd]pyrene and benzo[a]pyrene in mouse skin. Carcinogenesis 4 393-397... 

Fujiki, H., Suganuma, M., Nakayasu, M., Hakii, H., Horiuchi, T, Takayama, S., and Sugimura, T. 1986. Ealytoxin is a non-12-0-tetradecanoylphorbol- 13-acetate type tumor promoter in two-stage mouse skin carcinogenesis. Carcinogenesis 7, 707-710. 

Huang, M.T. et al.. Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis, 13,947,1992. 

Kamibayashi, Y., Oyamada, Y., Mori, M. and Oyamada, M. (1995). Aberrant expression of gap junction proteins (connexins) is associated with tumor progression during multistage mouse skin carcinogenesis in vivo. Carcinogenesis 16,1287-1297. 

Figure 2 Inhibitory effect of topical application of rooibos and honeybush extracts on skin tumor development over a 20 week period in a two-stage mouse skin carcinogenesis model (Data are from reference 54)...

EPA (1993) has derived the following relative potency estimates based on mouse skin carcinogenesis ... 

Bjelogrlic NM, Makinen M, Stenback F, et al. 1994. Benzo(a)pyrene-7,8-diol- 9,10-epoxide- DNA adducts and increased p53 protein in mouse skin. Carcinogenesis 15(4) 771-774. 

Higginbotham S, RamaKrishana NVS, Lohansson SL, et al. 1993. Tumor-initiating activity and carcinogenicity of dibenzo(a,/)pyrene versus 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene at low doses in mouse skin. Carcinogenesis 14(5) 875-878. 

Hughes NC, Phillips DH. 1990. Covalent binding of dibenzpyrenes and benzo(a)pyrene to DNA Evidence for synergistic and inhibitory interactions when applied in combination to mouse skin. Carcinogenesis (Eynsham) 11 (9) 1611-1620. 

Hughes NC, Pfau W, Hewer A et al. 1993. Covalent binding of polycyclic aromatic hydrocarbon components of coal tar to DNA in mouse skin. Carcinogenesis 14(1) 135-144. 

Rice JE, Hosted TJ, DeFloria MC, et al. 1986. Tumor-initiating activity of major in-vivo metabolites of indeno-1 2 3 -cd-pyrene on mouse skin. Carcinogenesis 7(10) 1761-1764. 

Abies sachalinensis (C.F.Schmidt) Mast, (bark) Spirobiflavonoids (abiesinols). All compounds exhibited potent inhibitory effects on ( )-(iI)-methyl-2-[( )-hydroxyimino]-5-nitro-6-methoxyhex-3-enamide (NOR 1) activation. A spirobiflavonoid showed remarkable anti-tumor-initiating activity in the in vivo two-stage mouse skin carcinogenesis test using peroxynitrite (ONOO PN) as the initiator and 12-O-tetradecanoyl-phorbol- 13-acetate (TPA) as the promoter. Wada et al., 2010[476]. 

Slaga, T. J., Budunova, I. V., Gimenez-Conti, I. B., and Aldaz, C. M. (1996). The mouse skin carcinogenesis model. J Investig Dermatol Symp Proc 1, 151—156. 

O Brien, T. G., The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis, Cancer Res., 36, 2644, 1976. 

Gupta KP and Mehrota NK. 1992. Status of ornithine decarboxylase activity and DNA synthesis in mancozeb-exposed mouse skin. Carcinogenesis 13 131-133. 

So far, no potential cancer chemopreventive agent constituent from a Hernandia species has been subjected to biological follow up after the initial in vitro investigation, e.g., by using a mouse mammary organ culture assay [75] or a two-stage mouse skin carcinogenesis test [86]. 

Volatile phenols represent one type of tumor promoter in tobacco smoke. In mouse-skin carcinogenesis, however, they evidently do not play an essential role as such, since a significant reduction of phenols in the smoke condensate is not accompanied by a similar reduction in carcinogenic activity of the tar [4332]. 

PAHs were described as the only major tumor initiators in mouse skin carcinogenesis [Wynder and Hoffmann (4332)] ... 

The contribution of BaP or PAH in general to mouse skin carcinogenesis by cigarette smoke condensate cannot be fully measured at this time. .. In the smoking and health program of the National Cancer Institute. .. no significant dependence of carcinogenic potency on BaP content was observed. 

---