Mouse induction skin carcinogenesis

Haesen, S., Timmermans, M. Kirsch-Volders, M. (1993) Induction of micronuclei and karyotype aberrations during in vivo mouse skin carcinogenesis. Carcinogenesis, 14, 2319-2327... 

O Brien, T. G., The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis, Cancer Res., 36, 2644, 1976. 

In the induction of skin carcinogenesis, the phorbol ester PMA was used as a potent tumor promoter in mouse skin. A NADPH oxidase system of neutrophil is dominant for O2 generating in TPA-treated mouse skin (15). ROS from leukocytes, including 0, plays an important role for continuous and excessive production of chemotactic factors, leading to chronic inflammation and hyperplasia. 

Bums, F.J., Vanderlan, M., Snyder, E. and Albert, R.E. (1976). Induction and progression kinetics of mouse skin papillomas. In Slaga, T.J., Sivak, A. And Boutwell, R.K. (Eds). Carcinogenesis, Vol. 2. Modifiers of Chemical Carcinogenesis. Raven Press, New York, pp. 91-96. 

Ftirstenberger, G., Schurich. B., Kaina, B., Petrusevska, R.T., Fusenig, N.E. Marks, F. (1989) Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate correlation between chromosomal damage and conversion ( stage I of tumor promotion ) in vivo. Carcinogenesis, 10, 749-752... 

Katiyar SK, Mohan RR, Agarwal R, Mukhtar H. 1997. Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols. Carcinogenesis 18 497-502. 

Many compounds that inhibit EBV-EA induction by TPA have been shown to act as inhibitors of tumor promotion in vivo [28]. Soyasaponin I (26) exhibited remarkable inhibitory effects on mouse skin tumor promotion on the basis of the two stage (DMBA-TPA) carcinogenesis... 

And, many compounds which showed strong inhibitory effects on the induction of EBV-EA by TPA have been shown to act as inhibitors of tumor promotion on two-stage carcinogenesis test in vivo [15-21, 27-29]. The one of two-stage carcinogenesis test is on mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a... 

Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, Kerns ML, Talalay P (2007) Induction of the phase 2 response in mouse and human skin by sutfinaphane-containing broccoli sprout extracts. Cancer Epidemiol Biomarkers Prev 16 847—851 Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, Talalay P. 2001. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci USA 98(6) 3404-3409. 

Monks, T.J., S.E. Walker, L.M. Flynn, C.J. Conti, and J. DiGiovanni. 1990. Epidermal ornithine decarboxylase induction and mouse skin tumor promotion by quinones. Carcinogenesis 11(10) 1795-1801. 

Hard T, Kellenbach E, Boelens R, Maler BA, Dahlman K, Freedman LP, Carlstedt-Duke J, Yamamoto KR, Gustafsson JA, Kaptein R (1990) Solution structure of the glucocorticoid receptor DNA-binding domain. Science 249 157-160 Hashiba H, Hosoi J, Karasawa M, Yamada S, Nose K, Kuroki T (1989) Induction of metallothionein mRNA by tumor promoters in mouse skin and its constitutive expression in papillomas. Mol Carcinogenesis 2 95-100 Kagi JHR (1991) Overview of metallothionein. Methods Enzymol 205 613-626 Kagi JHR, Schaffer A (1988) Biochemistry of metallothionein. Biochemistry 27 8509-8515... 

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