Molecules genes

Hellen, C. U., and Samow, P. (2001). Internal ribosome entry sites in eukaryotic mRNA molecules. Genes Dev. 15, 1593—1612. 

Lamb, J., Crawford, E.D., Peck, D., et al. (2006) The Connectivity Map using gene-expression signatures to connect small molecules, gene, and disease. Science, 313, 1929-1935. 

Lamb J, Crawford ED, Peck D et al. The Cormeetivity Map using gene-expression signatures to cormect small molecules, genes, and disease. Science 2006 313 1929-1935. 

Gene Ordered sequence of nucleotides located in a particular position on a particular chromosome and containing instructions to make a specific product, such as a protein molecule. Genes are the fundamental units of heredity. 

The fidelity of cellular repair and reproduction is determined by a coding system based on polynucleotides - deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). In general (with some inevitable exceptions of course), the information flow is from DNA molecules (genes) which are transcribed to yield RNA molecules which in turn are translated on complex macromolecular protein-RNA assemblies called ribosomes to yield proteins (polymers of amino acids linked by peptide bonds). 

Dickinson LA, Burnett R, Melander C, Edelson BS, Arora PS, Dervan PB, Gottesfeld JM. Arresting cancer proliferation by small-molecule gene regulation. Chem Biol. 2004 11 1583-1594. 

A Single-Molecule Gene Switch as a Many Body Problem... 

Vangipuram SD, Grever WE, Parker GC, Lyman WD (2008) Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression. Alcohol Clin Exp Res 32(2) 339-347... 

A large number of additional therapies have been or are under review. These therapies include nonsteroidal anti-inflammatory agents, proinflammatory agents (GM-CSF), antiadhesion molecules, gene therapy, antiendotoxin therapy, and antioxidants (e.g., superoxide dismutase)." Therapies will continue to focus on the early interventions to prevent the progressive downward spiral of lung injury, inflammation, and hypoxemia. 

Eichmann, A. Marcelle, C. Breant, C. Le Douarin, N.M. Molecular cloning of Quek 1 and 2, two quail vascular endothelial growth factor (VEGF) receptor-like molecules. Gene, 174, 3-8 (1996)... 

The human genome can be investigated at the proteome level through direct small molecule-gene product (protein) interactions using activity/affinity-based approaches. Such small molecule-protein interaction analysis serves several objectives and can be performed directly with cells, cell extracts, or alternatively applying isolated proteins in a parallel maimer. 

Appendix F-II. Cloning of Toxin Molecule Genes in Escherichia coli K-12 Appendix F-II-A. 

Appendix F-III. Cloning of Toxic Molecule Genes in Organisms Other Than Escherichia coli K Appendix F-I V. Specific Approvals... 

Cell adhesion molecule gene expression is upre-gulated in ischaemia/reperfusion. Kacimi etal. (1998) studied intercellular adhesion molecule (ICAM) response to cytokines and acute hypoxia in cultured myocardial cells. Northern blot analysis and immunoassay showed that the proinflammat-ory cytokines interleukin-ip and tumour necrosis factor-a stimulated concentration dependent in-... 

Lamb J (2006) The connectivity map Using Gene-Expression Signatures to Connect Small Molecules, Genes and Disease. Science 313 1929-1935... 

It is likely that biological specificity in general is the result of a detailed complementariness in structure of the interacting molecules. Enzymes are complementary in structure to a strained configuration of the reacting molecules. Genes are complementary nucleic acid chains, as discussed in Section 15-6. 

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