Gene order

Dandekar, T., Snel, B., Huynen, M., and Bork, P. (1998). Conservation of gene order a fingerprint ofproteins that physically interact. Trends Biochem. Sci. 23, 324-328. 

Sankoff, D., Leduc, G., Antoine, N. et al. (1992) Gene order comparisons for phylogenetic inference evolution of the mitochondrial genome. Proceedings of the National Academy of Sciences of the United States of America, 89 (14), 6575-6579. 

Inversions. When two breaks occur in the same chromosome, the portion between them is detached and becomes reinserted in the opposite way to its original position, that is, the gene order is reversed. This need not cause a genetic problem, but imbalanced gametes could result in congenital malformation or fetal death. 

The usage of gene order for orthology prediction is complicated by pathway duplication, the duplication of two or more genes from one pathway to produce a new pathway. In pathway duplication part of the... 

M. olivasterospora in both gene content and gene order a comparison is outlined in Table 2.18. Therefore, we here postulate that Frankia sp. CcI3 is able to produce FORs or a closely related AGA complex. 

Lercher MJ, Urrutia AO, Hurst LD. Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nature Gen 2002, 31, 180-183. 

Comparison of different plasmids with overlapping activities, such as the lower pathways encoded by the TOL and NAH plasmids, indicates a considerable similarity in terms of gene order and DNA sequence (Harayama et al., 1987 Assinder Williams, 1988 Assinder et al., 1993), suggesting a common origin. 

Harayama, S., Leppik, R. A., Rekik, M., Mermod, N., Lehrbach, P.R., Reineke, W. Timmis, K. N. (1986). Gene order of the TOL catabolic plasmid upper pathway operon. Journal of Bacteriology, 167, 455-61. 

Harayama, S., Rekik, M., Wasserfallen, A. Bairoch, A. (1987). Evolutionary relationship between catabolic pathways for aromatics conservation of gene order and nucleotide sequences for catechol oxidation genes of pWWO and NAH7 plasmids. Molecular General Genetics, 210, 241-7. 

Fig. 2.2. Diagrammatic Representation of Mitochondrial Gene Orders in Parasitic Flatworms.

Phylogenies inferred from mitochondrial gene orders - a cautionary tale from the parasitic flatworms. Molecular Biology and Evolution 1 7, 1 123-1 125. 

D Hoostelaere, L.A., Huppi, K., Mock, B., Mallett, C., Potter, M. (1988). The IgKL chain allelic groups among the IgK haplotypes and IgK crossover populations suggest a gene order. J. Immunol. 141,652-661. 

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