Molecule detection

Kneipp K, Wang Y, Kneipp H, Itzkan I, Dasari R R and Feld M S 1996 Approach to single molecule detection using surface-enhanced Raman scattering ICORS 98 XVth Int. Conf on Raman Spectroscopy ed S A Asher and P B Stein (New York Wley) pp 636-7... [Pg.1228]

Two-photon excited fluorescence detection at the single-molecule level has been demonstrated for cliromophores in cryogenic solids [60], room-temperature surfaces [61], membranes [62] and liquids [63, 64 and 65]. Altliough multiphoton excited fluorescence has been embraced witli great entluisiasm as a teclmique for botli ordinary confocal microscopy and single-molecule detection, it is not a panacea in particular, photochemical degradation in multiphoton excitation may be more severe tlian witli ordinary linear excitation, probably due to absorjDtion of more tlian tire desired number of photons from tire intense laser pulse (e.g. triplet excited state absorjDtion) [61],... [Pg.2493]

Weston K D, Carson P J, DeAro J A and Buratto S K 1999 Single-molecule detection fluorescence of surface-bound species in vacuum Chem. Phys. Lett. 308 58-64... [Pg.2505]

Goodwin P M, Ambrose W P and Keller R A 1996 Single-molecule detection in liquids by laser-induced fluorescence Acc. Chem. Res. 29 607-13... [Pg.2505]

Soper S A and Legendre B L Jr 1998 Single-molecule detection in the near-IR using continuous-wave diode laser... [Pg.2505]

Mertz J, Xu C and Webb W W 1995 Single-molecule detection by two-photon-excited fluorescence Opt Lett. 20 2532-4... [Pg.2506]

Williams J G K 1997 Single-molecule detection of specific nucleic acid sequences in unamplified genomic DNA Anal. Chem. 69 3915-20... [Pg.2511]

Haab B B and Mathies R A 1999 Single-molecule detection of DNA separations in microfabricated capillary electrophoresis chips employing focused molecular streams Ana/. Chem. 71 5137-45... [Pg.2511]

Interstellar molecules detected by their radiofrequency, microwave or millimetre wave spectra... [Pg.119]

As femtomolar detection of analytes become more routine, the goal is to achieve attomolar (10 molar) analyte detection, corresponding to the detection of thousands of molecules. Detection sensitivity is enhanced if the noise ia the analytical system can be reduced. System noise consists of two types, extrinsic and intrinsic. Intrinsic aoise, which represents a fundamental limitation linked to the probabiHty of finding the analyte species within the excitation and observation regions of the iastmment, cannot be eliminated. However, extrinsic aoise, which stems from light scatteriag and/or transient electronic sources, can be alleviated. [Pg.395]

Raschke, T. M., and Marqnsee, S., 1997. The kinetic folding intermediate of ribonnclease H resembles the acid molten globule and partially unfolded molecules detected under native conditions. Nature Structural Biology 4 298-304. [Pg.208]

Fig. 25-3. Some molecules detected in the solar atmosphere and the elements they contain.

FIGURE 2-19 Single-molecule detection with SECM. Molecule A is trapped between the tip and the surface. (Reproduced with permission from reference 58.)... [Pg.52]

Single molecule detection, 52, 128 Size exclusion films, 123 Sodium, 155... [Pg.209]

Zander Ch, Enderlein J, Keller RA (2002) (eds) Single molecule detection in solution. Methods and applications. Wiley-VCH, Weinheim, Germany... [Pg.189]

DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channels. Anal. Chem. 74 (2002) 1415-1422. [Pg.249]

Kneipp, K., Wang, Y., Kneipp, H., Perelman, L. T., Itzkan, I., Dasari, R. R. and Eeld, M. S. (1997) Single molecule detection using surface-enhanced Raman scattering (SERS). Phys. Rev. Lett., 78, 1667-1670. [Pg.54]

Oswald B, Gruber M, Bohmer M, Lehmann F, Probst M, Wolfbeis OS (2001) Novel diode laser-compatible fluorophores and their application to single molecule detection, protein labeling and fluorescence resonance energy transfer immunoassay. Photochem Photobiol 74 237-245... [Pg.103]

The molecules detected in ISM can also be classified according to the number of atoms they contain (Table 3.3). Compounds containing different isotopes (iso-topomers) are not listed. [Pg.79]

Buehler, C., Stoeckli, K. and Auer, M. (2001). The integration of single molecule detection technologies into miniturized drug screening Current status and future perspectives. In New Trends in Fluorescence Spectroscopy (Valeur, B. and Brochon, J. C., eds.). Springer, Berlin, pp. 331-79. [Pg.64]

Widengren, J., Kudryavtsev, V., Antonik, M., Berger, S., Gerken, M. and Seidel, C. A. (2006). Single-molecule detection and identification of multiple species by multiparameter fluorescence detection. Anal. Chem. 78,2039-50. [Pg.516]

Kneipp K., Kneipp H., Deinum G., Itzkan I., Dasari R.R., Feld M. S., Single-molecule detection of a cyanine dye in silver colloidal solution using near-infrared surface-enhanced Raman scattering, Appl. Spectrosc. 1998 52 175-178. [Pg.254]

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