Kinetic folding

Raschke, T. M., and Marqnsee, S., 1997. The kinetic folding intermediate of ribonnclease H resembles the acid molten globule and partially unfolded molecules detected under native conditions. Nature Structural Biology 4 298-304. 

Nishimura, C. Dyson, H.J. Wright, P.E. Identification of native and nonnative structure in kinetic folding intermediates of apomyoglobin. 

Jennings, P. A. Wright, P. E. (1993). Formation of a Molten Globule Intermediate Early in the Kinetic Folding Pathway of Apomyoglobin. Science 262, 892-896. 

Zhang, J., and Matthews, C.R. (1998) The role of ligand binding in the kinetic folding mechanism of human p21(H-ras) protein. Biochemistry 37, 14891-9. 

Fig. 5). This almost certainly excludes the recruitment of tran-sientiy populated PrP folding intermediates as precursors of PrP , which would be expected to cause significantly slower folding. Kinetic folding intermediates have been proposed for amyloid formation of human lysozyme mutants (Booth et al, 1997). 

In a number of subsequent studies of the 27-residue model, it was argued that the kinetic folding behavior is determined by factors other than the energy gap... 

Ubiquitin has been the subject of a number of experimental studies as it is a small and soluble protein without disulfide linkages. The protein has a well-defined and packed hydrophobic core. There are a number of kinetic folding studies on this system, in addition to a high resolution crystal structure. 2D NMR studies of a partially unfolded form of the protein in 60% methanol indicate that approximately one-half of the molecule contains dismpted but native-like structure, while the other half is unstmctured and/or contains non-native structure. The interpretation of hydrogen-exchange experiments have led to the conclusion that this state is native-like. ... 

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