Nanofluidic Systems for Single Molecule Detection

These nanopores were not fabricated in batches but made individually in expensive tools, and the fluid cells at each side of the nanopore are bulk fluid cells, which may consume a significant amount of sample. Efforts of making on-chip nanofluidic systems for single-molecule detection based oti the same principle started with a 3 pm long, 200 nm in diameter PDMS nanochannel on a glass substrate [3]. The channel size (200 nm) is much larger than a typical nanopore (<10 nm) due to the limitation of... 

For both detection approaches, it is of great interest to study the complex interactiOTis between the molecules of interest and the nanoenvironment. The high surface area to volume ratio in nanochannels can change the behavior of molecules significantly from that in bulk solutions. The complex interactions between the molecules of interest and the ions and surface charges are still not fully understood yet. These effects must be clarified before extensive applications of nanofluidic systems for single-molecule detection. 

Nanofluidic Systems for Single Molecule Detection, Figure 1... 

A schematic diagram of nanofluidic system for single molecule detection based on electrical current modulation when macromolecules are translocated through the nanochannel... 

These nanopores were not fabricated in batches but made individually in expensive tools and the fluid cells at each side of the nanopore are bulk fluid cells, which may consume a significant amount of sample. Efforts of making on-chip nanofluidic systems for single molecule detection... 

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