Molecular recognition combinatorial

H. P. Nestler and R. Liu, Combinatorial libraries studies in molecular recognition. Combinatorial Chemistry and High Throughput Screening, 1 (1998), 113—126. 

EMPl, selected by phage display from random peptide libraries, demonstrates that a dimer of a 20-residue peptide can mimic the function of a monomeric 166-residue protein. In contrast to the minimized Z domain, this selected peptide shares neither the sequence nor the structure of the natural hormone. Thus, there can be a number of ways to solve a molecular recognition problem, and combinatorial methods such as phage display allow us to sort through a multitude of structural scaffolds to discover novel solutions. 

Molecular recognition and the quest for new catalysts in combinatorial syntheses with participation and formation of heterocycles 97LA637. 

Much attention has recently been focused on organoboronic acids and their esters because of their practical usefulness for synthetic organic reactions including asymmetric synthesis, combinatorial synthesis, and polymer synthesis [1, 3, 7-9], molecular recognition such as host-guest compounds [10], and neutron capture therapy in treatment of malignant melanoma and brain tumor ]11]. New synthetic procedures reviewed in this article wiU serve to find further appHcations of organoboron compounds. 

Chemical templates are being increasingly employed for the development of dynamic combinatorial libraries (DCL) [94-98]. These (virtual) libraries of compounds are produced from all the possible combinations of a set of basic components that can reversibly react with each other with the consequent potential to generate a large pool of compounds. Because of the dynamic equilibria established in a DCL, the stabilization of any given compound by molecular recognition will amplify its formation. Hence the addition of a template to the library usually leads to the isolation of the compound that forms the thermodynamically more stable host-guest complex (see Scheme 37). 

PERMUTATIONS AND COMBINATIONS COMBINATORIAL LIBRARIES MOLECULAR RECOGNITION... 

Despite the remarkable progress in the field of molecular recognition, it is still extremely difficult to predict a priori the structure of a selective, high-affinity ligand for a metal ion such as Hg ". The approach we intend to pursue is to take advantage of combinatorial chemistry methods—a collection of technical advances that allow one to seriously consider undertaking the synthesis of hundreds or even thousands of compounds simultaneously —to carry out the parallel synthesis of a set of fOO potentially selective high-affinity fluorescent chemosensors for mercury. 

Molecular recognition is one of the keys to life. Scientists are discovering ways both to modify molecular recognition sites and to copy such sites. One approach to modifying molecular recognition sites, namely enzymatic protein sites, is through what is referred to as directed evolution. Arnold and coworkers have employed the combinatorial approach by... 

Combinatorial chemistry has matured from a field where efforts initially focused on peptide-based research to become an indispensable research tool for molecular recognition, chemical-property optimization, and drug discovery. Originally used as a method to primarily generate large numbers of molecules, combinatorial chemistry has been significantly influenced and integrated with other important fields such as medicinal chemistry, analytical chemistry, synthetic chemistry, robotics, and computational chemistry. 

David N. Reinhoudt is scientific director of the Laboratory of Supramolecular Chemistry and Technology, MESA Research Institute at the University of Twente in The Netherlands. His research is focused on supramolecular chemistry and technology including nanofabrication, molecular recognition, and non-covalent combinatorial synthesis [23, 24],... 

Schneider-Mergener, J., Kramer, A., and Reineke, U. (1996) Peptide libraries bound to continuous cellulose membranes tools to study molecular recognition. In Combinatorial Libraries Synthesis, Screening and Application Potential, ed. R. Cortese. New York Walter de Gruyter. 

Over the past several years, combinatorial libraries of biological molecules, such as peptides and nucleic acids, have proven invaluable as reagents with which to study molecular recognition of proteins and non-proteins. Such libraries have been used extensively to define the specificity of protein/protein, protein/RNA, protein/peptide, and RNA/small molecule interactions. 

Combinatorial chemistry, in addition to facilitating the drug discovery process, is also an invaluable tool for basic research, particularly in the area of molecular recognition. Many biologically important molecular interactions involve proteins or peptides. Peptide libraries, therefore, will continue to be an extremely useful tool for basic research. 

Ludlow RF, Otto S (2010) The impact of the size of dynamic combinatorial libraries on the detectability of molecular recognition induced amplification. J Am Chem Soc 132 5984—5986... 

Keywords Anions Dynamic combinatorial chemistry Molecular recognition Self-assembly Supramolecular chemistry... 

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