Combinatorial chemistry dynamic

This dynamic process is commonly known as constitutional dynamic chemistry (CDC). While the concept of dynamic covalent chemistry defines systems in which the molecular (or supramolecular) reorganization proceeds via reversible covalent bond formation/breakage, dynamic systems based on noncovalent linkage exchanges define the concept of dynamic noncovalent chemistry. Dynamic combinatorial chemistry (DCC) can be defined as a direct application of CDC where libraries of complementary functional groups and/or complementary interactional groups interexchange via chemical (i.e., covalent) reactions or physical (i.e., noncovalent) interactions. 

Figure 9. A dynamic combinatorial chemistry library used to identify a carbonic anhydrase inhibitor.

J.-M. Lehn, Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries , Chem. Eur. J. 1999, 5, 2455-2463. 

Dynamic Combinatorial Chemistry, edited by Benjamin L. Miller Copyright 2010 John Wiley Sons, Inc. 

With these selected examples as context, it became clear to several laboratories in the mid-1990s that one should be able to combine reversible formation of compounds (exchange processes) and a selection method with the then rapidly developing field of combinatorial chemistry to produce equilibrating libraries that would evolve based on some selection process. Thus, dynamic combinatorial chemistry or DCC, as it came to be called, evolved from a number of lines of research into the diverse and vibrant field it is today. 

Other terms have been employed for this general concept, including self-assembled combinatorial libraries, constitutional dynamic chemistry, and virtual combinatorial libraries . Dynamic combinatorial chemistry and dynamic combinatorial library seem to have found the broadest usage, while virtual combinatorial library is perhaps best reserved for conditions under which library members form at concentrations below detection limits in the absence of target (e.g.. Reference 81). 

Perez-Fernandez, R. Pittelkow, M. Belenguer, A. M. Sanders, J. K. M. Phase-transfer dynamic combinatorial chemistry. Chem. Commun. 2008, 1738-1740. 

Corbett, P. T Sanders, J. K. M. Otto, S. Systems chemistry Pattern formation in random dynamic combinatorial libraries. Angew. Chem. Int. Ed. 2007, 46, 8858-8861. 

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