Molecular recognition induced

Fig. 45. Schematic representation of the formation of an ordered supramolecular strand by the molecular-recognition-induced association of two different molecular units each unit contains a group that possesses two identical binding sites complementary to those of the other unit [9.119].

Molecular Recognition Induced Self-organization and NLO Effects... 

Molecular recognition directed self-assembling of organized phases has been described recently in the formation 1) of mesophases by association of complementary molecular component, as in 13 (23) 2) of supramolecular liquid crystalline polymers of type 14 (24) and 3) of ordered solid state structures, such as that represented by 15 (25). In all these cases, the incorporation of NLO active groups may be expected to produce materials whose SHG properties would depend on molecular recognition induced self-organization. 

Ludlow RF, Otto S (2010) The impact of the size of dynamic combinatorial libraries on the detectability of molecular recognition induced amplification. J Am Chem Soc 132 5984—5986... 

The initial event is the binding of ferri-heme to hemopexin in the plasma, which induces a conformational change in the protein and enables high-affinity molecular recognition by cells expressing the... 

Molecular recognition is obviously a critical component (and often the primary goal) of DCC-based molecular discovery, and the molecular recognition community was instrumental in developing experiments that directly prefigured the development of DCC. Two examples from the Lehn group are illustrative. In 1990, Lehn and coworkers reported that mixtures of tartrate-based compounds could be induced to form liquid... 

Watanabe O. (2004) Molecular recognition and immobilization ofbiomolecules induced byphoto-irradiation on the sufrace of an azopolymer. R D Review of Toyota CRDL 39, 46. 

In Figure 30, all types of molecular recognition systems discussed above are mapped graphically as a function of the complexation-induced conformational change (a) and desolvation (TAS ). As can be seen from Figure 30, both parameters, a and TASq, do not appear to correlate each other, and the molecular recognition... 

The observation of single channel currents may suggest the successful self-organization of supramolecular channels. This process may require several steps (1) incorporation of the amphiphilic carboxylate-ammonium ion pair into the bilayer lipid membrane (2) molecular recognition of the relatively polar oligoether chain from the surrounding hydrophobic lipid components to induce domain formation of molecular level and (3) interlayer connection of these hydrophilic domains existing in different lipid layers. 

The hydrophobic cavity provided by the octopus cyclophane is significantly flexible, and capable of performing molecular recognition toward hydrophobic guest molecules of various bulkiness through the induced-fit mechanism, not only in aqueous solution but in the bilayer membrane formed with a synthetic peptide lipid. However, such a flexible hydrophobic cavity seems to be unfavorable for size-sensitive molecular discrimination. 

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