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Molecular function solution

The column should permit the modulation of retention behavior over a very wide range of conditions. This requirement in fact means that the stationary phase is inert, that is it does not facilitate specific interactions with certain molecular functions of solute molecules with the concomitant advantage of a relatively clean and rapid adsorption-desorption kinetics. Preferably then the stationary phase has no functional groups such as fixed charges that would have strong affinity to counterionic solutes and exclude solutes of co-ionic nature. In this regard the properties of well-prepared hydrocarbonaceous bonded phases indeed approach those that we would expect from an ideal phase. [Pg.237]

Two and Three-Parameter Simplexes (38). Three combinations of variables were examined (a) density gradient/temperature, (b) pressure gradient/temperature gradient, and (c) initial density/density gradient/temperature. Two samples were tested (i) a synthetic mixture of 6 diverse, low-to-medium molecular weight solutes of varying polarity and functionality (acetophenone, propiophenone, bicyclohexyl, biphenyl, undecylbenzene and benzophenone) and (ii) a mixture of 3 difficult-to-separate sesquiterpene lactones—glaucolide A, burrodin, and psilostachyin A. [Pg.322]

Probably the most convincing evidence that crystalline structures can safely be used to draw conclusions about molecular function is the observation that many macromolecules are still functional in the crystalline state. For example, substrates added to suspensions of crystalline enzymes are converted to product, albeit at reduced rates, suggesting that the enzyme s catalytic and binding sites are intact. The lower rates of catalysis can be accounted for by the reduced accessibility of active sites within the crystal, in comparison to solution. [Pg.33]

If some or all of the ensemble conformations reveal actual alternative conformations in solution, then these models contain useful information that may be lost in producing the averaged model. If the most important conformations for molecular function are represented in subsets of models within the final ensemble, then an averaged model may mislead us about function. Just like crystallographic models, NMR models do not simply tell us what we would like to know about the inner workings of molecules. Evidence from other areas of research on the molecule are necessary in interpreting what NMR models have to say. [Pg.237]

Philo, J. S. (1997). An improved function for fitting sedimentation velocity data for low-molecular-weight solutes. Biophys. J. 72(1), 435—444. [Pg.235]

Perturbation of enzyme stmcture or function by environmental stress can often be counteracted by the actions of specifically selected low molecular weight solutes whose effects on the enzyme oppose those of the perturbing stress. This type of adaptation is well developed where cells face dehydration and/or high salt concentration. Species that are desiccation tolerant and freeze tolerant (extracellular ice... [Pg.165]

Because of these difficulties we turn to inversion procedures which are valid in the semiclassical limit since this approximation has proved to be applicable for most of the atomic and molecular collisions. Solutions of the second step, the determination of the potential, are treated in Section IV.B.2. In general, the input information will be the phase shifts or the deflection function. Only in the high energy approximation can the potential be derived directly from the cross section. For a detailed discussion of these procedures see Buck (1974). The possibilities of determining the phase shifts or the deflection function from the cross section are treated in Section IV.B.3. The advantage of such procedures and the general requirements on the data are discussed in Section IV.B.4. The emphasis will be on procedures which have been applied to real data. Extensions to non-central or optical interaction potentials are available. Most of them, however, are still in a formal state, so that a direct application to molecular physics is not obvious. Two exceptions should be mentioned. One is a special inversion procedure for optical potentials derived by a perturbation formalism (Roberts and Ross,... [Pg.337]

The characteristics of water in the neighborhood of mixed-functional solutes containing both polar and nonpolar groups will be reviewed and illustrated by the detailed results obtained from a molecular dynamics simulation of a dilute aqueous solution of an alanine dlpeptlde. Both the solvent effect on the dlpeptlde and that of the dlpeptlde on the solvent will be described. [Pg.41]

If we consider the nuclei A and B to be both hydrogen nuclei, then the atomic orbitals of A and B will be Is orbitals. Solution of this molecular orbital function leads to two molecular functions of the form ... [Pg.28]


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See also in sourсe #XX -- [ Pg.64 , Pg.65 , Pg.66 , Pg.67 , Pg.68 , Pg.69 , Pg.70 ]




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