3- -propionic acid, methyl

A mixture of B g (0.0356 mol) of p-(2.2-dichlorocyclopropyl)phenol, 11.2 g (0.2B mol) of sodium hydroxide pellets, 11 g of chloroform and 350 ml of acetone was prepared at 0°C. The cooling bath was removed, the mixture stirred for a minute and then heated on a steam bath to reflux temperature. The reaction mixture was stirred at reflux for three hours and then concentrated in vacuo. The residual gum was partitioned between dilute hydrochloric acid and ether, and the ether layer was separated, dried and concentrated in vacuo. The residual oil (14 g) was partitioned between dilute aqueous sodium bicarbonate and ether. The sodium bicarbonate solution was acidified with concentrated hydrochloric acid and extracted with ether. The ether solution was dried over anhydrous sodium sulfate and concentrated. The residue (9.5 g of yellow oil) was crystallized twice from hexane to give 6.0 g of 2-[p-(2,2-dlchlorocyclopropyDphenoxyl -2-methyl propionic acid in theformof apalecream[Pg.347]

In a more detailed study, the same esterase P. fluorescens) was again subjected to mutagenesis using the same mutator strain, but also by saturation mutagenesis at selected positions 133a). In addition to 3-phenylbutyric acid ethyl ester (27), 3-bromo-2-methyl-propionic acid methyl ester rac-31) was chosen for the hydrolytic kinetic resolution, with the WT PFE showing an E factor of 12 in favor of the (5)-32. 

R)- or (S)-3-hydroxy-2-methyl-propionic acid methyl ester... 

The use of extracellular lipases of microbial origin to catalyze the stereoselective hydrolysis of esters of 3-acylthio-2-methylpropionic acid in an aqueous system has been demonstrated to produce optically active 3-acylthio-2-methyl-propionic acid [41-43], The synthesis of the chiral side chain of captopril by the lipase-catalyzed enantioselective hydrolysis of the thioester bond of racemic 3-acetylthio-2-methylpropionic acid (15) to yield 5 -(-)-(15) has been demonstrated [44], Among various lipases evaluated, lipase from Rhizopus oryzae ATCC 24563 (heat-dried cells), BMS lipase (extracellular lipase derived from the fermentation of Pseudomonas sp. SC 13856), and lipase PS-30 from Pseudomonas cepacia in an organic solvent system (l,l,2-trichloro-l,2,2-tri-fluoroethane or toluene) catalyzed the hydrolysis of thioester bond of undesired enantiomer of racemic (15) to yield desired S-(-) (15), R-(+)-3-mercapto-2-methylpropionic acid (16) and acetic acid (17) (Fig. 8A). The reaction yield of... 

CJ Sih. Process for preparing optically active 3-acylthio-2-methyl propionic acid derivatives. European Patent 87264125, Derwent International Publication W087105328, 1987. 

Ethylbenzene is not the only monomer that can be cross-linked with divinylbenzene to get a cross-linked polymer. By using the addition polymerization process, if methyl propionic acid (see Figure 7.20) and divinylbenzene are cross-linked, it is possible to obtain methacrylic divinylbenzene, a weakly acidic cationic resin (Figure 7.21) [118]. 

Preparation of 2-(2-Chloro-Acetylamino)-2-Methyl Propionic Acid... 

R)-3-Hydroxy-2-methyl propionic acid, an important building block for the synthesis of the widely used antihypertensive drug captopril, was obtained with 97% enantiomeric excess (e.e.) and 100% molar conversion by microbial oxidation of prochiral 2-methyl -1,3-propandiol with Acetobacter pasteurianus [25]. 

Useful whole cell asymmetric oxidations of methyl groups to carboxyl groups have been found by classical microbiological screening as for the microbial oxidation of prochiral 2-methyl-l,3-propandiol to (R)-3-hydroxy-2-methyl propionic acid with A. pasteurianus with 97% e.e. and 100% molar conversion [113],... 

Figure 7.12 show the results of a validation study. The task was to identify bioisosteric replacements for fragments in known PPAR (peroxisome pro-liferator-activated receptor) ligands. Fibrates are therapeutic agents for the treatment of metabolic disorders and activate PPARoc, a member of the PPAR family.It has been demonstrated that the 2-methyl-propionic acid moiety 7.6 is responsible for the selectivity of fibrates toward PPARa. SQUIRRELnovo suggests bioisosteric replacement for this group. These groups have been patented for action on PPARoc. ... 

SYNS ETHYL ISOBUTANOATE ETHYLISOBUTY-RATE POT ETHYL-2-METHYLPROPANOATE ETHYL-2-.METHYLPROPIONATE FEMA No. 2428 ISOBUTYRIC ACID, ETHYL ESTER 2-METHYL-PROPIONIC ACID, ETHYL ESTER... 

Fig. 6 A possible route to 3,3,3-trifluoro-2-hydroxy-2-methyl-propionic acid using an oxynitrilase. The route to the (S)-cya-nohydrin and (S)-acid is shown.

McHale, D., Laurie, W.A., Saag, K., and Sheridan, J.B. (1989) Photoreactions of quinine in aqueous citric acid solution. III. Products formed in aqueous 2-hydroxy-2-methyl-propionic acid, Tetrahedron, 45, 2127-2130. 

Beilstein Handbook Reference) AI3-10621 BRN 1737628 EINECS 209-060-4 FEMA Number 2742 HSDB 5688 Methyl propanoate Methyl propionate Methyl propylate Methylester kyseliny propionove NSC 9375 Propanoic acid, methyl ester Propionate de methyle Propionic acid, methyl ester UN1248. Uquid mp = -87.5° bp = 79.8° d = 0.9150 Xm = 211 nm (e = 62, isooctane), 204 nm (eb 50, H2O) slightly soluble in H2O, soluble in MejCO, CCI4, freely soluble in EtOH, Et20. 

Synonyms Acrylic acid, 2-methyl- MAA 2-Melhylacrylic acid a-Methylacrylic acid a-Methylacrylic acid (monomer) 2-Melhylene propionic acid 2-Methylpropenoic acid 2-Methyl-2-propenoic acid 2-Propenoic acid, 2-methyl- Propionic acid, 2-melhylene-... 

Chlorophenoxy-2-methyl) propionic acid 2-(p-Chloro-o-tolyloxy) propionic acid CMPP MCPP 2-MCPP... 

Acrolein Benzyl chloride Calcium resinate Caprylic acid Caprylic alcohol Caprylyl chloride Chlorobenzene Methylal Propionic acid Sodium bisulfate Xylene... 

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