Menopausal symptoms isoflavones

KNIGHT D c, HOWES J B, EDEN J A (1999) The effect of Promensil , an isoflavone extract, on menopausal symptoms. Climacteric. 2 79-84. 

Somekawa et al., 2001 Japanese peri/post-menopause n = 478 The high isoflavone intake group (65 mg/d) had significantly higher BMD of the lumbar spine compared to the low intake group (35 mg/d). Some menopausal symptoms were better alleviated in the high vs low intake group... 

Baber, R. J., Templeman, C., Morton, T., Kelly, G.E. and West, L. (1999). Randomised placebo-controlled trial of an isoflavone supplement and menopausal symptom in women, Climacteric, 2, 85-92. 

Knight, D.C., Howes, J.B., Eden, J.A. and Howes, L.G. (2001). Effects on menopausal symptoms and acceptability of isoflavones-containing soy powder dietary supplementation. Climacteric, 4, 13-18. 

St Germain, A., Peterson, C.T., Robinson, J.G. and Alekel, D.L. (2001). Isoflavone-rich or isoflavones-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment, Menopause, 8, 17-26. 

Although there is some controversy about how much soy must be consumed to benefit from its phytoestrogen effect, it is beheved that two servings per day will modestly reduce menopausal symptoms and the risk of breast cancer. More than three servings may reduce cholesterol. Although it has yet to be proved that dietary soy will stop osteoporosis, a synthetic isoflavone, ipriflavone, has been used in Japan and Europe to treat osteoporosis. Large doses of soy (6-8 servings per day) are believed by some to help this condition as well. 

Considerable evidence exists from epidemiological and experimental studies for preventive effects of soy or isoflavones against chronic diseases including cancer (breast, prostate, colorectal, lung), osteoporosis, cardiovascular disorders, and menopausal symptoms, but this is not always consistent [Adlercreutz... 

Until recently, HRT was widely prescribed for relief of menopausal symptoms, which include hot flushes, night sweats, mood swings, memory lapses, and propensity for weakening of the bones. Nutraceuticals are now being widely taken to counter these symptoms, most frequently isoflavones, DHEA, and Pycnogenol. 

One trial using 80 mg daily of isoflavones from red clover reported a 44 /o reduction in hot flushes, while another study reported no clinically important effects on either hot flushes or other menopause symptoms. ... 

The North American Menopause Society position statement for treatment of mild menopause-associated vasomotor symptoms recommends first trying lifestyle changes, either alone or in combination with nonprescription remedies such as dietary isoflavones, black cohosh, or vitamin E. Studies suggest that there is a modest reduction in vasomotor symptoms with soy supplementation and that higher doses of soy isoflavones may be needed. Black cohosh does not have phytoestrogenic effects, and the evidence of its efficacy for menopausal symptoms is Dong quai, a traditional... 

Messina, M. C.L. Hughes. The efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flash frequency, J. Medicinal Foods 2003, 6, 1-11. 

The evidence base for soy products having efiects on hormone-sensitive conditions is inconclusive. Soy products may reduce menopausal symptoms in postmenopausal women, although the current literature does not demonstrate effects of soy products on other hormone-sensitive conditions. However, importandy, clinical outcomes were not evaluated for most hormone-sensitive conditions. Conclusions are limited because of the relatively small numbers of studies and marked heterogeneity in design and in the profile of soy isoflavones across studies. 

Cimifuga racemosa Nutt. Black cohosh Roots Premenstrual symptoms, dysmenorrhea, menopausal symptoms Triterpene glycosides (cimifugaside, actein), isoflavones... 

Glycine max L. Soybean Source Adapted from different sources. Seeds, sprouts Menopausal symptoms, heart health Isoflavones... 

Hidalgo, L.A., P.A. Chedraui, N. Morocho, S. Ross, and G. San Miguel. 2005. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women A randomized, double-bUnd, placebo-controlled study. Gynecol. Endocrinol. 21(5) 257-264. 

Systematic reviews In a meta-analysis of randomized trials of isoflavones, given for menopausal symptoms, adverse events occurred in 2019 of 5502 women taking phytoestrogens (37%) and 1824 of 4806 (38%) who took placebo, a non-significant difference [lO ]. Hormone-related adverse effects and reactions, endometrial... 

Isoflavones (2) are naturally occurring phytochemicals, belonging to one of the major classes of phytoestrogens. By today, many evidences reveal that isoflavones (2) could epidemiologically be effective in their alternative preventions and treatments for many hormone-dependent diseases such as cancer, menopausal symptoms, cardiovascular disease and osteoporosis. Because plant originated-isoflavones (2), and human estrogens (1) which are formed in the ovary, adrenal cortex, testis and fetoplacental unit with various functions in both sexes have structurally their very close similarity, isoflavones (2) could bind to human estrogen receptors [1]. 

It has been eonsidered that isoflavones (2) could highly reveal their alternative treatment effects against the hormone-dependent conditions such as cancer, menopausal symptoms, cardiovascular disease and osteoporosis. 

Dietary consumption of foods and food additives containing isoflavone phytoestrogens has been associated with several beneficial properties to human health (Table 60.5), such as prevention of coronary heart disease and osteoporosis, reduction of menopausal symptoms, and prevention of distinct cancer forms (e.g., breast, prostate, and colon cancer) [19, 20]. The potential health benefits of isoflavones for humans have been the subject of several reviews that have analyzed clinical, animal, and in vitro evidence for biological activity [5]. Several studies have reported that isoflavone consumption by... 

Cheng G, Wilczek B, Warner M, Gustafsson JA, Landgren BM (2007) Isoflavone treatment for acute menopausal symptoms. Menopause 14 468-473... 

Isoflavones (genistein, daidzein) Soybeans, legumes, soy-based food products Antioxidant, lower LDL cholesterol, reduce menopause symptoms, increase bone strength... 

Menopausal symptoms Moderate number ofRCTs but many of poor quality. Soy isoflavones may be effective in reducing hot flushes but inconclusive. Not relevant. Evidence insufficient. 

Jacobs, A., Wegewitz, U., Sommerfeld, C., Grossklaus, R., and Lampen, A. 2009. Efficacy of isoflavones in relieving vasomotor menopausal symptoms—A systematic review. Mol Nutr Food Res 53, 1084-1097. 

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