Cholesterol reducer

Several groups have studied the structure of chiral phases illustrated in Fig. IV-15 [167,168]. These shapes can be understood in terms of an anisotropic line tension arising from the molecular symmetry. The addition of small amounts of cholesterol reduces X and produces thinner domains. Several studies have sought an understanding of the influence of cholesterol on lipid domain shapes [168,196]. 

D. B. Anderson and co- Foods Technologies and Strategies, Vol. 12, The... 

Another appHcation of 4-chlorophenol is in the synthesis of a dmg, ethyl a, a-dimethyl-4-chlorophenoxy acetate [637-07-0] (60), used as a cholesterol-reducing agent. This synthesis involves reaction with acetone and chloroform, followed by ethanol esterification. 

Low cholesterol egg products are formed by extraction of cholesterol from the egg. Attempts have been made to extract cholesterol by using hexane or by supercritical CO2 extraction methods (24,25). A whole egg product in which 80% of the cholesterol is removed by a process using beta-cyclodextrin, a starch derivative, added to egg yolks has been introduced. The cyclodextrin binds up to 80% of the cholesterol, the mixture is centrifuged, and the Hquid separated. The cholesterol-reduced yolk is then blended with egg white, pasteurized, and packed in asceptic containers to give a Hquid whole egg product having a shelf Hfe of 60 days under refrigeration (see Eood packaging). 

Therapeutic Function Cholesterol-reducing agent Chemical Name 2,2 -(decamethylenedithio)diethanol Common Name -... 

Mott GE, AW Brinkley, CL Mersinger (1980) Biochemical characterization of cholesterol-reducing Eubacterium. Appl Environ Microbiol 40 1017-1022. 

Cholesterol Reduced Foods Technologies and Strategies, ed. G. Bray, Portfolio Publishing, Wood, TX, Chapter 5, pp. 43-73 (1990). 

This procedure was used in the synthesis of the cholesterol-reducing drug lescol.131 The diethylmethoxyboron can be prepared in situ from triethylboron and one equivalent of methanol. 

Ma YL, Bryant HU, Zeng Q, Palkowitz A, Jee WSS, Turner CH, et al. (2002) Long-term dosing of arzoxifene lowers cholesterol, reduces bone turnover, and preserves bone quality in ovariectomized rats. J Bone Miner Res 17 2256-2264... 

Baychlor Cholesterol reducing (satin) Rhabdomyolysis (muscleweakening) (deaths)... 

When properly formulated, soy protein allows for significant cost savings, increased yields, reduced fat, increased protein, reduced cholesterol, reduced sodium and/or reduced calories while maintaining muscle tissue integrity. Applicable finished products include ham, roast beef, chicken, turkey, seafood and other whole muscle foods. Finished product characteristics given specific goals and guidelines are outlined as are new product opportunities. 

Cholesterol reducer in 10,20,40, and 80 mg doses Active ingredient Atorvastatin calcium... 

Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds. Ezetimibe does not inhibit cholesterol synthesis in the liver or increase bile acid excretion. 

Calfee, Winston, and Stempski (2002), using national U.S. monthly data on retail prescriptions, as well as for cholesterol-reducing drugs, in 1995-2000, found little if any impact from DTCA on the pattern of statin... 

Calfee, John E., Clifford Winston, and Randolph Stempski. 2002. Direct-to-Consumer Advertising and the Demand for Cholesterol-Reducing Drugs. Journal of Lave and Economics 14(2) 673-690. 

Results from two clinical studies of the interaction of diltiazem with simvastatin showed that diltiazem increased the Cmax of simvastatin (40) and enhanced its cholesterol-reducing effect (39). 

As expected, due to the small headgroup area of cholesterol (Achol = 40 A2, while ADOpc = 72 A2) [40, 41], the membrane charge density of DOTAP/DOPC/ Chol-DNA complexes increases with cholesterol content. Exchanging DOPC for cholesterol reduces the total membrane area while the membrane charge, given by dotap = 0-3, remains constant thus cM increases. A particularly strong increase in cM occurs for Choi > 0.4, where part of the cholesterol is not incorporated in the complex. This results in an increased <2>DOTap and thus aM. 

Schreier et al. [85] examined the effects of liposome encapsulation on the pharmacokinetics in sheep of amikacin, a water-soluble aminoglycoside. The dmg was formulated in 200 nm liposomes and administered by means of intratracheal instillation. The liposome formulations were soy PC/phosphatidyl glycerol (PG) (7 3 molar ratio) and soy PC/PG/CH (4 3 3). They found that both liposome formulations reduced plasma Cmax and prolonged the plasma half-life of the amikacin compared with the dmg administered as a solution, once again indicating that liposomes were controlling dmg delivery in the lungs. The inclusion of cholesterol in liposomes more than tripled the plasma half-life for the dmg compared with the liposomes without cholesterol. Cholesterol reduces the fluidity and permeability of liposomes in their liquid crystalline phase. 

Maintain Ideal Body Weight Reduce Total Fat (Z Calories) Reduce Saturated Fat Increase Poly- unsaturated Fat Reduce Cholesterol Reduce Simple Sugars Increase Complex Carbo- hydrates Reduce Sodium Moderation in Alcohol Other Recom- mendations... 

The high-value HMG-CoA reductase inhibitor Simvastatin (8) is marketed by Merck under the name Zocor. The active ingredient is obtained from a fermentation approach. It is very similar in structure to lovastatin, which has fallen from the top-sellers list. Lovastatin (9) is also a cholesterol-reducing drug that is isolated from Aspergillus terreus.51-60 It is still obtained by fermentation,61 and with the current advances in molecular biology,62 64 chemical approaches are not able to compete in a cost-effective manner.65-67 The usage of lipases allows for the manipulation of the butyric acid sidechain to access other HMG-CoA reductase inhibitors such as simvastatin.68 A number of routes to various portions of lovastatin have been reported.69... 

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