Memory deterioration

Qin, W., Zhao, W., Ho, L., Wang, J., Walsh, K., Gandy, S., and Pasinetti, G.M. 2008. Regulation of forkhead transcription factor Fox03a contributes to calorie restriction-induced prevention of Alzheimer s disease-type amyloid neuropathology and spatial memory deterioration. Annals oftheNew York Academy of Sciences, 1147, 335-347. 

It is true that older scientists who still produce research of high quality, do not as a rule reach the very highest level of their earlier work—in contrast to the older artist whose quality is much less age-dependent. Which of the essential qualities required for creative research is liable to deteriorate with advancing years Not the capacity for hard work. Imagination usually remains but perhaps in a more limited way, not as unprejudiced and not as revolutionary as in youthful days. The accumulated knowledge and experience is no less extensive but may become somewhat stale because retentive memory deteriorates with the years, so that the rapid flow of new information may be less well retained and less effectively assimilated into the general body of knowledge. 

The consequences of such memory deterioration cannot all be described. Among them, one can mention ... 

Software can experience code rot (assumptions go out of date), bit rot (memory deterioration), memory leaks (memory shortage), and so on. 

Acute clinical signs of neurotoxicity, manifested by hyperexcitability, dyspnea, decreased respiration, tremors, and convulsions, were identified in the available literature as effects caused by high doses of endosulfan. Exposure to high levels of endosulfan in humans may possibly be associated with permanent brain damage as manifested by cognitive and emotional deterioration, memory impairment, and... 

Dementia is the loss of function in multiple cognitive domains that occurs over a longer period of time, usually months to years. Diagnostic features include memory impairment and at least one of the following aphasia (deterioration of speech), apraxia (impaired ability to execute motor activities despite intact motor abilities, sensory function, and comprehension of the required task), agnosia (failure to recognize or identify objects despite intact sensory function), or disturbances in executive functioning.1... 

In 1991, Sony introduced the first lithium-ion battery and other manufacturers quickly followed. Lithium-ion is a low maintenance battery, there is no memory and no scheduled cycling is required to extend the battery s life. A protection circuit is used to prevent metallic lithium plating from an overcharge. Some capacity deterioration occurs after a year and lifetime is usually two or three years, but some lithium-ion packs are known to have served for five years in some applications. 

Mercury can be a cumulative poison, which means that minor amounts absorbed over long periods of time build up until damage to internal organs occurs. Years ago, a mercury compound was used in the manufacturing process of felt hats. Workers who came in contact with the mercury developed a variety of medical problems, including the loss of hair and teeth and loss of memory along with general deterioration of the nervous and other systems. This became known as the mad as a hatter syndrome because of the afflicted individuals odd behavior. 

D-Cycloserine is a central partial agonist of NMDA receptors in place of P-glycine, which in low doses has shown an antagonism of cognitive deterioration induced by scopolamine. Confusion, disorientation, and memory loss have been observed at high doses. D-Cycloserine can provide a symptomatic treatment of AD at low dosage (Bowen et al. 1992 B. L. Schwartz et al. 1996). 

Administration of scopolamine to rats induces amnesia in passive avoidance learning. EGb administered intraperitoneally 30 mm before the initial trial at doses of 150-500 mg/kg significantly attenuated the amnesic effects of scopolamine on step-through latencies in a retention trial 4 hours after training for the passive avoidance test in rats [107]. Hoyer et d. showed that, using an animal model of in tracer ebroventricular streptozotocin treatment, EGb treatment compensated for deterioration in working memory, reference memory and passive... 

Uppsala University bestows a Jubilee doctorate on those alumni who have survived fifty years after their commencement. Thus it was that Per-Olov received a new laurel and an additional diploma on May 29, 1998 as well as a two shot salute by the artillery cannon outside the university aula. The president of the student union saluted the five recipients with a speech that was answered by Per-Olov in his characteristically youthful style. Five months later he had a serious heart operation. He never recovered fully. His health deteriorated, and he passed away quietly on October 6, 2000. A memorial symposium was arranged at Uppsala on the day before the funeral, on October 26. Many of Per-Olov s colleagues and friends also gathered on the University of Florida campus to honor his memory with eulogies by Per-Olov s long time collaborator and friend Harrison Shull and by Robert A. Bryan, who held many top administrative positions at UF, including that of President, during most of Per-Olov s tenure at Florida. The 42 nd Sanibel Symposium held in 2002 was dedicated to his memory. 

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