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Membrane hydrophobic part

In contrast, the transmembrane helices observed in the reaction center are embedded in a hydrophobic surrounding and are built up from continuous regions of predominantly hydrophobic amino acids. To span the lipid bilayer, a minimum of about 20 amino acids are required. In the photosynthetic reaction center these a helices each comprise about 25 to 30 residues, some of which extend outside the hydrophobic part of the membrane. From the amino acid sequences of the polypeptide chains, the regions that comprise the transmembrane helices can be predicted with reasonable confidence. [Pg.244]

The combination of hydrophilic and hydrophobic parts of a molecule defines its amphiphilicity. A program has been described to calculate this property and calibrated against experimental values obtained from surface activity measurements [133]. These values can possibly be used to predict effect on membranes leading to cytotoxicity or phospholipidosis, but may also contain information, not yet unraveled, on permeability. Surface activity measurements have also been used to make eshmates of oral absorphon [126]. [Pg.40]

Phospholipids are amphiphilic substances i.e. their molecules contain both hydrophilic and hydrophobic groups. Above a certain concentration level, amphiphilic substances with one ionized or polar and one strongly hydrophobic group (e.g. the dodecylsulphate or cetyltrimethylammonium ions) form micelles in solution these are, as a rule, spherical structures with hydrophilic groups on the surface and the inside filled with the hydrophobic parts of the molecules (usually long alkyl chains directed radially into the centre of the sphere). Amphiphilic substances with two hydrophobic groups have a tendency to form bilayer films under suitable conditions, with hydrophobic chains facing one another. Various methods of preparation of these bilayer lipid membranes (BLMs) are demonstrated in Fig. 6.10. [Pg.450]

Let us first consider the lipid molecular structures required. First is the hydrophobic matching. The length of the hydrophobic chain determines the thickness of the hydrophobic part of the lipid bilayer, this should correspond closely to the dimension of the native membrane. As most biological membranes contain diacylglycerol lipids with hydrophobic chain lengths of 16 18 carbon atoms. Thus, synthetic lipids should possess relatively long hydrocarbon chain length, e.g., 16-18 carbon atoms. [Pg.141]

We have encountered examples of simple lipid bilayers earlier. These bilayers are composed largely of amphipathic molecules. In water, they have their hydrophobic parts occupying the center of the bilayer and their hydrophilic parts occupying the bilayer surface. Such bilayers form a continuous and essential structural feature of virtually all biological membranes. We need to distinguish between that layer which faces out from the cell and is in contact with the external environment, the exoplasmic leaflet, and that which faces in and is in contact with the cellular contents, the cytoplasmic leaflet. As we shall see, these two aspects of the lipid bilayer are quite distinct. [Pg.258]

It follows from study of the kinetics of transfer of ions across the phase boundary between two immiscible electrolyte solutions (see chapter 9) that ion-exchanger ions, where the ion is as nearly as possible symmetrically surrounded by hydrophobic groups on all sides, are especially suitable. Amphiphilic (amphipathic) substances, in whose molecules the hydrophobic part is separated from the hydrophilic part, are less suitable because they have a tendency to become adsorbed on the membrane/water phase boundary, thus retarding ion transfer across this boundary. [Pg.176]

Phospholipids, when dispersed in water, may exhibit self-assembly properties (either as micellar self-assembly aggregates or larger structures). This may lead to aggregates that are called liposomes or vesicles. Liposomes are structures that are empty cells and that are currently being used by some industries. They are microscopic vesicles or containers formed by the membrane alone, and are widely used in the pharmaceutical and cosmetic fields because it is possible to insert chemicals inside them. Liposomes may also be used solubilize (in its hydrophobic part) hydro-phobic chemicals (water-insoluble organic compounds) such as oily substances so that they can be dispersed in an aqueous medium by virtue of the hydrophilic properties of the liposomes (in the alkyl region). [Pg.101]

In Figure 1.2, the hydrophobic parts of the protein molecules form the outer surface of the cylinders shown and hold the molecules in place, away from water, in the hydrocarbon part of the bilayer. The inner surfaces of the cylinders are hydrophilic and allow the transfer of ions and polar molecules from one side of the bilayer to the other. These pathways remain closed until an appropriate internal or external stimulus triggers them to open to allow transport across the membrane. [Pg.5]

Besides the so-called integral membrane proteins (which are embedded in the hydrophobic part of the bilayer) there are peripheral proteins adsorbed on the hydrophilic surface of the membrane. Some of these peripheral proteins act as support, because they are associated with several integral proteins. A well known example is spectrin, situated at the inside of the erythrocyte membrane Z). [Pg.3]

Methacryloylic lipid (5) is polymerizable in the hydrophobic part of the molecule. The phase transition temperature of the polymeric vesicle is again lowered compared to the non-polymerized vesicle (Fig. 27). The difference between the phase transition temperatures of monomer and polymer is somewhat larger than in the case of acrylamide (29). This might indicate that a saturated polymer chain in the hydrophobic core of a membrane decreases membrane order to a higher extent than a polymer chain on the membrane surface 15). [Pg.26]

As an example of an asymmetric membrane integrated protein, the ATP synthetase complex (ATPase from Rhodospirillum Rubrum) was incorporated in liposomes of the polymerizable sulfolipid (22)24). The protein consists of a hydrophobic membrane integrated part (F0) and a water soluble moiety (Ft) carrying the catalytic site of the enzyme. The isolated ATP synthetase complex is almost completely inactive. Activity is substantially increased in the presence of a variety of amphiphiles, such as natural phospholipids and detergents. The presence of a bilayer structure is not a necessary condition for enhanced activity. Using soybean lecithin or diacetylenic sulfolipid (22) the maximal enzymatic activity is obtained at 500 lipid molecules/enzyme molecule. With soybean lecithin, the ATPase activity is increased 8-fold compared to a 5-fold increase in the presence of (22). There is a remarkable difference in ATPase activity depending on the liposome preparation technique (Fig. 41). If ATPase is incorporated in-... [Pg.39]

In the present study, therefore, lipid membranes were used as transducers of taste information. Artificial lipid materials, such as dioleyl phosphate (DOPH) or dioctadecyl-dimethyl-ammonium, were used to construct a lipid membrane and responses of electrical potential and resistance of the membranes were measured [9-15]. It was confirmed that the lipid membranes could discriminate five primary taste substances. Moreover, they could detect the interactions between taste substances observed in biological systems. The response properties were different in different types of lipids. If a hydrophobic part of a lipid was different, taste substances which can be detected were different. These facts indicate that the taste sensor can be realized by the use of various kinds of lipid membranes as transducers. [Pg.379]

The behavior of a substance in a biological system depends to a large extent upon whether the substance is hydrophilic (water-loving) or hydrophobic (water-hating). Some important toxic substances are hydrophobic, a characteristic that enables them to traverse cell membranes readily. Part of the detoxification process carried on by living organisms is to render such molecules hydrophilic, therefore water soluble and readily eliminated from the body. [Pg.80]

Fig. 14.7. A scheme of the bilayer lipid membrane. The black circles indicate the polar heads (the hydrophilic part) consisting of phosphoric acid, ethanol amine, and analogue derivatives. The wavy lines are the long alkyl chains of fatty acids (the hydrophobic part) (Reprinted from J. Koryta, Ions, Electrodes and Membranes, Fig. 83. Copyright J. Wiley Sons, Ltd. 1991. Reproduced with permission of J. Wiley Sons, Ltd.)... Fig. 14.7. A scheme of the bilayer lipid membrane. The black circles indicate the polar heads (the hydrophilic part) consisting of phosphoric acid, ethanol amine, and analogue derivatives. The wavy lines are the long alkyl chains of fatty acids (the hydrophobic part) (Reprinted from J. Koryta, Ions, Electrodes and Membranes, Fig. 83. Copyright J. Wiley Sons, Ltd. 1991. Reproduced with permission of J. Wiley Sons, Ltd.)...

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See also in sourсe #XX -- [ Pg.19 ]




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