Medical Research Council, British

The Medical Research Council/British Heart Foundation study controlled the activity of antioxidants in the protection of a large group of patients (10,629) suffering from coronary disease who were treated daily with vitamin supplementation (vitamin E 600 mg, vitamin C 250 mg, and /3-carotene 20 mg). Similar high dosages were used in Age-Related Eye Disease Study (vitamin E 400 Ul, vitamin C 500mg, and /3-carotene 15 mg). In both studies the results were not positive. In these last two studies as in any of the studies reported in Table 9 the OS was measured to determine the real need of an antioxidant therapy. 

Medical Research Council/British Heart Foundation. 

East Africa/British Medical Research Council (1972) Lancet 1 1079... 

We would like to thank all our colleagues in Manchester for allowing us to discuss their unpublished work. Research in this laboratory has received funding from the BBSRC, the British Medical Research Council, and The Wellcome Trust. 

The best break we have had with cancer has come from epidemiology. Concerned with rising British mortality from lung cancer, the Medical Research Council, in 1947, commissioned Austin Bradford Hill (1897-1991) and Richard Doll (1912-) to analyse the possible causes. Their meticulous statistical survey (published in 1951) of patients from twenty London hospitals showed that smoking is a factor, and an important factor, in the production of cancer of the lung. ... 

Medical Research Council (1959) Maximum permissible dietary contamination after the accidental release of radioactive material from a nuclear reactor. British Medical Journal, i, 967-9. 

The technique of randomization was pioneered in the field of agriculture (plants too show considerable individual variation) by Sir Ronald Fisher, a visionary statistician. It is generally acknowledged that the first randomized clinical trial, conducted in the 1940s, was a study evaluating the use of streptomycin in treating tuberculosis conducted by the (British) Medical Research Council Streptomycin in Tuberculosis Trials Committee. The results were published in the British Medical Journal in 1948. 

Work in the authors laboratory was supported by grants from the Medical Research Council (UK), British Diabetic Association, Scottish Home and Health Department, SERPA and California Metabolic Research Foundation (USA). 

There are several definitions of respirable dust (Lippmann, 1970). In 1952 the British Medical Research Council (BMRC) defined the respirable fraction in terms of the terminal settling velocity (free-falling speed) by the equation... 

LaRue LJ, Alter M, Traven ND et al. (1988). Acute stroke therapy trials problems in patient accrual. Stroke 19 950-954 Marshall M, Lockwood A, Bradley C et al. (2000). Unpublished rating scales a major source of bias in randomised controlled trials of treatments for schizophrenia British Journal of Psychiatry 176 249-252 Medical Research Council Working Party (1985). MRC trial of treatment of mild... 

Tanzanian/British Medical Research Council Collaborative Study. Tuberculosis in Tanzania—a national survey of newly notified cases. Tubercle 1985 66(3) 161-78. 

Singapore Tuberculosis Service and British Medical Research Council. Controlled trial of intermittent regimens of rifampicin plus isoniazid for pulmonary tuberculosis in Singapore. Lancet 1975 2(7945) 1105-9. 

Research on epithelial injury in the author s laboratory was supported by the Medical Research Council, The National Asthma Campaign, The British Lung Foundation and The Royal Society. Special thanks are due to Carolyn Herbert, Patrick Ring and Julia Carver who have been centrally involved in undertaking studies on mucosal injury in the author s laboratory. I would like to thank Kemi Olaniyan for her assistance in preparation of the manuscript. 

The antisyphilitic drug arsphenamine (Salvarsan) had been discovered in Germany in 1907 and was imported into Britain until the outbreak of the First World War, when the Board of Trade issued licences to certain British manufacturers to make it. Each batch had to be submitted to the Medical Research Council for approval before marketing. The problem was that although it was synthetic, and hence the chemical identity of the product was knotvn, highly toxic impurities could only be detected by biological testing. 

British government publication documents Department of Science and Industrial Research, Meteorological Office, Board of Trade, Medical Research Council, Aeronautical Research Coimcil... 

This work was supported by the Medical Research Council of Canada and Inex Pharmacouticals Corp. D. L. Reimer was an MRC Postdoctoral Fellow at the time of this work. E. K. Wasan is supported through a B.C. Science Council Graduate Research, Engineering and Technology fellowship. F.M.P. Wong is a recipient of a fellowship from the Science Council of British Columbia and the Cancer Research Society, Inc. P. Harvie is a FRSQ post-doctoral fellow. 

It was quite clear that the scale of production in the William Dunn School could barely provide enough material for further clinical trials hence, Florey tried to elicit the help of drug companies. ICI, Burroughs Wellcome, Boots and a small London company, Kemball-Bishop, all showed interest but due to the exigencies of war-tom Britain, none had sufficient funds for speculative research. They were probably also worried that a chemical synthesis of penicillin would be devised once its structure had been elucidated thus, money spent on culture technology would be wasted. They were also probably worried about the patent situation. Florey had mentioned this issue to the Medical Research Council, which had provided a modest amount of research money. Apparently, the senior MRC officials were vehemently opposed to patenting on the grounds that it was unethical for medical researchers to benefit from their discoveries. The American pharmaceutical companies suffered no such qualms of conscience, and in due course the British companies had to pay royalties to their US counterparts before they could produce penicillins. 

The assays to be discussed in the following sections are based on bovine TSH (standards), and most studies of the biochemical effects of TSH have involved the use of b-TSH. International standards are available for both b-TSH and h-TSH assays, and these may be obtained from the British Medical Research Council. The response to a particular TSH varies with the type of assay (Bl). Therefore, when TSH is assayed, dose response curves must be based on a reference standard. Species variation is valuable in identifying differences between TSH and other TSH-like material. LATS, for example, does not stimulate thyroid function in the chick (L3). 

Their leader does not appear in the photograph. Dr Paul Fildes, at that time in his early sixties, was arguably Britain s top bacteriologist a Fellow of the Royal Society, founder of the British Journal of Experimental Pathology and editor of the great nine-volume System of Bacteriology published by the Medical Research Council in 19 31. 

Medical Research Council Streptomycin in Tuberculosis Trials Committee (1948) Streptomycin treatment for pulmonary tuberculosis. British Medical Journal ii 769-782. 

British) Medical Research Council papers from its Committee on Protection Against Ionizing Radiations, as follows Maximum permissible dietary contamination after the accidental release of radioactive material from a nuclear reactor. Brit. Med. J. 1,967-969 (1959) Maximum permissible contamination of respirable air after an accidental release of radioiodine, radiostrontium and caesium 137. Brit. Med. J. ii, 576-579 (1961) Report on emergency exposure to external radiation, in Hazards to Man of Nuclear and Allied Radiations, Appendix K, Cmnd 1225, HM Stationery Office, London, I960. 

British) Medical Research Council, Criteria for Controlling Radiation Doses to the Public after Accidental Escape of Radioactive Material, HM Stationery Office, London, 1975. 

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