Medical laboratories

Normal values / ranges for medical / laboratory /technical procedures and/or tests included in the protocol... 

Updates of medical / laboratory / technical procedures / tests... 

Medical laboratories, of course, must never disclose any results except to the patient or the doctor in charge of a case. 

Dybowski, R. Gant, V. Artificial neural networks in pathological and medical laboratories. Lancet 1995,346,1203-1207. 

Analytical investigations are always carried out to serve a definite purpose. In this respect analytical results have to be evaluated and interpreted. In modern fields of applications like environmental monitoring, foodstuff control, medical laboratory diagnostics etc., conclusions have to be drawn about the presence of given species and their amount as well as the exceeding of limit values or falling significantly below them. 

Although, MediChem is a biosecurity products manufacturer, its biotechnology-based R D capabilities are worth mentioning here. The attended markets include Medical, Laboratory, Veterinary, and Environmental sectors. Medicinal chemistry services and drug discovery form the basis of the company, though their capabilities might be applied in a broader range of sectors. These capabilities comprise the areas of Proteomics, Combinatorial and Computational Chemistry, Medicinal Chemistry, Enzymes, Process Development, Analytical and Separations Chemistry, Chemical Synthesis and Scale Up. 

Medical laboratories have some specific needs and these are incorporated in ISO 15189 2003, Medical Laboratories - Particular Requirements for Quality and Competence [8]. The requirements of both ISO 9001 and ISO/IEC 17025 are incorporated within this Standard. It is a customized version of ISO/IEC 17025 for medical laboratories. In the UK, UKAS have designated Clinical Pathology Accreditation (UK) Ltd as the authoritative body to accredit against this Standard. 

This Standard was prepared specifically to cover medical laboratories. These laboratories carry out testing or examination of materials derived from the human body. Such studies are carried out for the purpose of providing information for the diagnosis, prevention and treatment of disease or assessment of the health of an individual. ISO 15189 covers a whole range of tests relating to clinical measurements, e.g. chemical and microbiological. This Standard is based on ISO 9001 and ISO/IEC 17025 and contains a correlation between the clauses and those in ISO 9001 and ISO/IEC 17025. 

Medical Laboratories - Particular Requirements for Quality and Competence , ISO 15189 2003, International Organization for Standardization (ISO), Geneva, Switzerland, 2003. 

Comstock, C.C., and F.W.Oberst. 1952. Inhalation toxicity of aniline, furfuryl alcohol and their mixtures in rats and mice. Medical Laboratories Research Report 139, Chemical Corps Medical Laboratories, Army Chemical Center. 

There are medical tests to determine whether you have been exposed to mirex. Levels of mirex can be measured in blood, feces, fat, or milk. The tests are not done in routine medical examinations. However, doctors can collect tissue and body fluid samples and send them to university medical centers or medical laboratories where the tests can be performed. The tests are specific for mirex exposure. Since mirex is stored in your body for a long time and slowly excreted, the tests can detect mirex for a long time after exposure has stopped. However, the tests are unsatisfactory indicators of the amount of mirex to which you have been exposed. This is because a long time may have passed since you were exposed and you cannot be sure how much mirex may have left your body by the time the test is performed. The tests also cannot be used to predict whether you will experience any potential health effects or harmful changes following exposure. 

Medical, laboratory and care applications transparent pre-filled syringes, pharmaceutical containers and packages, primary packaging of pharmaceuticals, medical devices, diagnostic disposables, laboratory ware. .. 

Colonel Douglas Lindsey, MD (1918-1999). Trained as a surgeon, he commanded the Edgewood Arsenal Medical Laboratories from 1959 to1962... 

I was in California at the time, spending two years at Stanford as a postdoctoral student, courtesy of the Army. Dr. Fred Sidell, who had taken over as acting Dq)artment Chief, told me the horrible story in a letter. I imagined the shock that everyone in the Medical Laboratories must have experienced and felt very sad, but grateful not to have had to endure it all up close. 

To keep things simple, we deliberately left antidotes out of the design. We also thought it best to carry out the experiment indoors, in a secure environment. Less than a month earlier, we had tried an outdoor test with some worrisome results. These occurred when Colonel Frank Bauer, Doug Lindsey s replacement as Chief of the Medical Laboratories, approved our request to construct an obstacle course to test volunteer performance in a physically challenging outdoor environment. 

Meanwhile, the Chief of the Clinical Research Division, the Chief of the Medical Laboratories and the Scientific Director of the Chemical Research and Development Laboratory (CRDL) were all saying No, most assuredly no to the young major. Since he apparently could only take yes for an answer, he relayed my lone positive response to a higher level. There, he found his sought-... 

Fred Sidell had done an heroie job during my absenee. Under his leadership, Clinical Research was publishing more researeh papers than any of the other three Medical Laboratory departments. Most reports were classified, but it was encouraging that some had been approved for open pubheation in mainstream... 

Personally, I thought the relatively strict secrecy policy was overkill. I always believed that truthful advocacy could work wonders. Defense policy makers clearly thought otherwise, which made me somewhat of a heretic. As a natural nonconformist, I always talked freely about our program whenever I had a chance to interact with the public. My first opportunity to do this came in 1969. Colonel Joe Blair, recently promoted from Chief of the Medical Laboratories to Deputy Director of Medical Sciences in the larger Chemical Research and Development Laboratory down the street, asked me to take his place at a meeting in Salt Lake City. 

In due eourse, the AP sent a letter to the Director of the Medical Laboratories, quoting my invitation, and requesting permission to visit. Unfortunately, Secretary of Defense Laird had just plaeed an embargo on all media visits to our facility. Sensing a ground swell of anti-Chemieal Corps sentiment, the Administration had invoked the elassified shibboleth, hoping to minimize publicity. 

In September 1955, the Commander of the Edgewood Arsenal Medical Laboratories formally requested permission to use volunteers in research involving nonlethal psychochemicals. This was largely a result of the Wolff Committee s final report, which included a detailed plan for field experiments involving small units. 

This chapter gives the background on the accreditation of testing and calibration laboratories according to ISO/IEC 17025 and sets out the requirements of this international standard. ISO 15189 describes similar requirements especially tailored for medical laboratories. Because of these similarities ISO 15189 is not separately mentioned throughout this lecture. 

The accreditation according to ISO/IEC 17025 (or ISO 15189 for medical laboratories) has turned out to be the most important and worldwide valid standard for competent testing and calibration laboratories... 

ISQ 15189 2007 - Medical laboratories - Particular requirements for quality and competence... 

Furthermore, the equivalence in the way both the laboratoiy accreditation standard and the certification standard deal with the management system requirements illustrates that an accredited laboratory meets, in practice, these requirements as specified in ISO 9001. After a proposal made via Eurachem and EA to ILAC, a similar joint Communique was agreed and signed in September 2009 by ILAC, lAF and ISO for medical laboratories against ISO 15189 2007. 

Comstock CC, Oberst FW Inhalation Toxicity of Aniline, Furfuryl Alcohol and Their Mixtures in Rats and Mice. Chemical Corps Medical Laboratories Research Report No. 139, October 1952... 

Mercon products are American Dental Association (ADA) approved and have been used in the dental, surgical, and medical laboratory environments for over a decade. The Mercon product line includes the following products Mercondrum , Mercongel , Merconvap ,... 

When using medical laboratories, physicians frequently assume that the results provided are accurate and precise. Those working in the laboratory environment know that this is true only within the constraints of the methods, technology and processes available. In this chapter we will explore how internal quality control (IQC) and external quality assurance (EQA) procedures can inform both the analyst and the physician about the limitations of laboratory testing and permit a more intelligent use of laboratory data, while at the same time indicating areas where improvement is required. 

ISO 17025 1999, which covers the general requirements for the competence of testing and calibration laboratories, or ISO 15189 2002, which includes particular requirements for quality and competence in medical laboratories extending to post-analytical aspects including the reporting of results. 

U.S. Army. Chemical Corps Medical Laboratories Research Reports No. 23, 50 (Army Chemical Center, Edgewood Arsenal, MD, U.S.A.) see ref 8. 

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