Maudsley

Maudsley A A, Filial S K, Perman W FI and Simon FI E 1983 Spatially resolved high-resolution spectroscopy by 4-dimensional NMR J. Magn. Reson. 51 147-52... 

Y. Kobayashi and D. V. Maudsley, Biological Applications ofEiquid Scintillation Counting, Academic Press, Inc., New York, 1974. 

Ciraulo DA, Rotrosen J, Leiderman D, et al Nefazodone induced alterations of cocaine craving and use in dysphoric cocaine users. Drug Alcohol Depend 60 S38, 2000 Connell PH Amphetamine Psychosis (Maudsley Monographs No 5). London, Oxford University Press, 1938... 

A search of Medline, EMBASE and PsycLIT was conducted in August 2000, using the following terms Amisulpride, clozapine, olanzapine, risperidone, sertindole, zotepine, ziprasidone, economics, healthcare, costs. All manufacturers of atypical antipsychotic drugs were contacted in April 2000 and asked to supply primary reference data on their product, and all companies had complied with this request by August 2000. A further manual search was conducted of files and journals kept in the National Centre for Information on Psychotropics at the Maudsley Hospital. Reference sections from all retrieved papers were scrutinized for further relevant references. 

Professor Kerwin has published very widely on many aspects on the use of drugs in mental illness. His publications include Neurobiology and Psychiatry (Cambridge University Press, 1995) and the Maudsley 2001 Prescribing Guidelines (Martin Dunitz, 2001). 

Honorary Consultant at the Maudsley Hospital and sees patients with anxiety, sleep and depressive disorders. He is on the advisory boards of about 25 international scientific journals. 

David Taylor is Chief Pharmacist at the South London and Maudsley NHS Trust. Honorary Senior Lecturer at the Institute of Psychiatry and Foundation President of the College of Mental Health Pharmacists. His main areas of research are pharmacokinetics and prescribing practice in mental health. His team at the Maudsley is widely involved in systemic reviews and meta-analyses of psychotropic drug therapy. David is lead author of the Maudsley 2001 Prescribing Guidelines (Martin Dunitz, 2001) and co-editor of Case Studies in Psychopharmacology (Martin Dunitz, 1998). 

Oil and 0)2, and (b) 2D shift-correlation spectra, involving either coherent transfer of magnetization [e.g., COSY (Aue et al, 1976), hetero-COSY (Maudsley and Ernst, 1977), relayed COSY (Eich et al, 1982), TOCSY (Braunschweiler and Ernst, 1983), 2D multiple-quantum spectra (Braun-schweiler et al, 1983), etc.] or incoherent transfer of magnedzation (Kumar et al, 1980 Machura and Ernst, 1980 Bothner-By et al, 1984) [e.g., 2D crossrelaxation experiments, such as NOESY, ROESY, 2D chemical-exchange spectroscopy (EXSY) (Jeener et al, 1979 Meier and Ernst, 1979), and 2D spin-diffusion spectroscopy (Caravatti et al, 1985) ]. 

Drugan, RC, Basile, AS, Crawley, JN, Paul, SM and Skolnick, P (1987) Peripheral benzodiazepine binding sites in the Maudsley Reactive rat selective decrease confined to peripheral tissues. Brain Res. Bull. 18 143-145. 

When we began using reserpine at the Maudsley Hospital less than two years ago there were very few reliable accounts of its use in the treatment of neuropsychiatric conditions and almost no controlled clinical studies. Dr D. L. Davies and I therefore conducted a clinical trial on a mixed group of out-patients, the majority of whom were suffering from anxiety and depressive reactions. The patients were given either reserpine, prescribed as Serpasil in a dose of 0.5 mg. by mouth twice daily, or a seemingly identical placebo, for a period of six weeks. The two substances... 

Govindaraju, V., Young, K., Maudsley, A. A. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 13 129-153, 2000. 

Pierce KL, Maudsley S, Daaka Y, Luttrell LM, Lefkowitz RJ (2000) Role of endocyto-sis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proc Natl Acad Sd 97 1489-1494... 

Ahmed FP, McLaughlin DP, Stanford SC, Stamford JA (2002) Maudsley reactive and non-reactive (MNRA) rats display hehavioral contrasts on exposure to an open field, the elevated plus maze or the dark-light shuttle hox. Abstract, FENS, Paris, France Ammassari-Teule A, Milhaud JM, Passino E, Restivo L, LassaUe JM (1999) Defective processing of contextual information may he involved in the poor performance of DBA/2 mice in spatial tasks. Behav Genet 29 283-289 Anisman H, Zalcman S, Shanks N, Zacharko RM (1991) Multisystem regulation of performance deficits induced hy stressors an animal model of depression. In Boulton AA, Baker GB, Martin-lverson MT (eds) Animal models in psychiatry, vol 2. Humana Press, Clifton, pp 1-59... 

Berrettini WH, Harris N, Ferraro TN, Vogel WH (1994) Maudsley reactive and non-reactive rats differ in exploratory behavior but not learning. Psychiatr Genet 4 91-94 Bizard DA, Altman HJ, Freedman LS (1982) The peripheral sympathetic nervous system in rat strains selectively bred for differences in response to stress. Behav Neural Biol 34 319-325... 

Blizard DA, Adams N (2002) The Maudsley reactive and nonreactive strains a new perspective. Behav Genet 32 277-299... 

Frangou, S. (1999) The Maudsley early onset schizophrenia study abnormal genes, abnormal brains, abnormal families. Biol Psychiatry 45 12S. 

Connell PH (1958). Amphetamine Psychosis. Institute of Psychiatry Maudsley Monograph No. 5. London Oxford University Press Conner KR, Pinquart M Duberstein PR (2008). Meta-analysis of depression and substance use and impairment among intravenous drug users (IDUs). Addiction, 103, 524-34... 

Cooper JE, Kendell RE, Gurland BJ, et al. Psychiatric diagnosis in New York and London a comparative study of mental hospital admissions. Institute of Psychiatry, Maudsley Monographs, no. 20. London Oxford University Press, 1972. 

Petursson, H. and Lader, M.H. (1984) Dependence on Tranquillisers, Institute of Psychiatry Maudsley Monographs, no. 28, Oxford University Press. ... 

Maudsley Alcohol Pilot Project (1975) Designing a Comprehensive Community Response to Problems of Alcohol Abuse, Report to DHSS. 

Jenny Wilks is a Clinical Psychologist with the Maudsley Drug Training Unit, Camberwell, London. 

Taylor, D. McConnell, H., McConnell, D., Abel, K., and Kerwin, R. (1999) The Bethlem and Maudsley NSH Trust. Prescribing Guidelines, 5th edition. London, Martin Dunitz. 

The primary function of GRK-mediated receptor phosphorylation is to promote the recruitment of another crucial protein, named P-arrestin,to the activated receptor. Arrestin binds to GPCRs and inhibits further coupling to G proteins hence desensitizing the response (Ferguson 2001 Penn et al. 2001 Pierce et al. 2002 Maudsley et al. 2005). P-arrestin belongs to the arrestin family of which four members have been identified (Gurevich et al. 2008). 

An excellent example of this is provided by the case of Henry Maudsley, one of the most enlightened psychiatrists of his day, and for whom a leading mental hospital in London is presently named. In his fine paper "Masturbational Insanity," E. H. Hare (1962) notes that Maudsley wrote, "In the... 

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