Clinical controlled

General Antibacterial Properties. In the clinical control of bacterial infectious disease, the aminoglycosides gentamicin, tobramycin, amikacin, netilmicin, and to a lesser extent, dibekacin and isepamicin are most commonly used for the treatment of serious infections involving aerobic or facultative gram-negative baciUi, especially in the compromised host. This usage is discussed in the Hterature (44—51). 

Data collection in clinical trials consists of the processes of collecting reliable clinical, control, and administrative data from the trial s participating sites... 

A. Albisser, B. Lebel, G. Ewart, Z. Davidovac, C. Botz, and W. Zingg, Clinical control of diabetes by artificial pancreas. Diabetes 23, 397-404 (1974). 

Lazzaro C, Salanitri T, Spitaleri S, Lazzaro Danzuso GC Effectiveness and tolerance of topical rifaximin treatment for pyodermatosis. Clinical controlled trial vs chlortetracycline. Med Praxis (Milan) 1992 13 1—11. 

Although there is some evidence for an antiseizure effect of kava, it is not clear whether these effects extend to humans. There have not been any studies that have demonstrated its effectiveness in clinically control-... 

The most important determinant of appropriate dosing is clinician s judgment of the patients response to therapy the clinician must monitor the patients response in terms of clinical control and adjust the dose accordingly. Once control of asthma is achieved, the dose medication should be carefully titrated to the minimum dose required to marntam control, thus reducing the potential for adverse effects. 

Phencyclidine is typically self-administered by the oral, intravenous, or smoked routes. After oral administration to healthy human volunteers, the bioavailability was found to vary between 50 and 90%.4 In this study, peak plasma concentrations were achieved after 1.5 h and appeared to correlate with the time to reach maximum pharmacological effects. However, because there have been no comprehensive clinical controlled studies of phencyclidine, a correlation between PCP blood concentrations and pharmacological effects has not been definitively documented. Maximum serum PCP concentrations ranged between 2.7 and 2.9 ng/ml after 1 mg PCP administered orally.4... 

Despite these relatively successful results, transcorneal iontophoresis has never been studied in randomized, clinically controlled studies. The reason could be that the common topical drops treatment is relatively successful in treating most anterior ocular disorders with very few complications even though it requires frequent treatment. 

Christensen JH, Gustenhoff P, Korup E, Aaroe J, Toft E, Moller JM, Rasmussen K, Dyerberg J, Schmidt EB. n-3 polyunsaturated fatty acids, heart rate variability and ventricular arrhythmias in post-AMI-patients. A clinical controlled trial. Ugeskr Laeger. 1997 159 5525-5529. 

In view of the loss of complex biochemical liver functions, drug intervention in the metabolic processes of the liver should be as varied as possible - even the use of therapeutic agents which are not clinically controlled may be biochemically or pharmacologically justified. 

Krusell L, Nielsen HK, Baelum J, Lundqvist G, Omiand O, Vaeth M, Husted SE, Mogensen CE, Geday E. Renal effects of chronic exposure to organic solvents a clinically controlled trial. Acta Med Scand 1985 218 323-327. 

BAL should be administered carefully and under strict clinical control in patients with hypertension, hepatic, or renal impairment, and G6PD deficiency. 

About 30% of patients whose seizures are clinically controlled will have persistent electrical manifestations (i.e., still in status) and will remain in GCSE after administration of these anticonvulsants. When a patient develops refractory GCSE, a neurologist with expertise in epilepsy should be consulted, and an intense search should be performed for an acute or progressive cause. ... 

Although the exact cause of psoriasis is unknown, in a majority of patients, pharmacotherapy is usually effective in establishing good clinical control. Psoriasis may be a lifelong relapsing and remitting disease, so therapy should be selected with careful consideration of long-term adverse effects. Major points for consideration include the extent and site of disease involvement, the patient s age, and concurrent associated diseases. 

Several clinical controlled trials have evaluated treatment with inhaled insulin. In 779 type 2 patients with an HbAlc >8% the availability of inhaled insulin as a treatment option significantly increased the proportion of patients who would theoretically choose insulin treatment [57], Thus, patients were three times more likely to choose insulin when inhaled insulin was available compared with conventional insulin treatment [57],... 

Arnold GL, et al. Methylcitrate/citrate ratio as a predictor of clinical control in propionic acidemia. J Inherit Metab Dis. 2003 26(suppl 2) 37. 

R. Duncan, S. Gac-Breton, R. Keane, R. Musila, Y. N. Sat, R. Satchi and F. Searle, Polymer-drug conjugates, PDEPT and PELT Basic principles for design and transfer from the laboratory to clinic, /. Control. Release, 74,135-146 (2001). 

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