Matrix metalloproteinases activation

McQuibban GA, Butler GS, Gong JH, Bendall L, Power C, Clark-Lewis I, Overall CM (2001) Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. J Biol Chem 276 43503 3508... 

Ellerbroek, S.M. et al. (2001) Functional interplay between type I collagen and cell surface matrix metalloproteinase activity./. Biol. Chem. 276(27), 24833-24842. 

M. Schafers, B. Riemann, K. Kopka, H.J. Breyholz, S. Wagner, K.P. Schafers, M.P. Law, O. Schober, B. Levkau, Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivo. Circulation 109 (2004) 2554-2559. 

Redford EJ, Smith KJ, Gregson NA, Davies M, Hughes P, Gearing AJ, Miller K, Hughes RA (1997b) A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-alpha processing attenuates experimental autoimmune neuritis. Brain 120 1895-1905. 

Two further perspectives on the use of tetracychnes in rheumatoid arthritis have been pubhshed (14,15). In addition to an effect on matrix metalloproteinases, the authors focused on a potential antiarthritic action of tetracyclines by their effects in the interaction between the generation of nitric oxide, matrix metalloproteinase release, and chondrocyte apoptosis. Both minocychne and doxycycline inhibit the production of nitric oxide from human cartilage and murine macrophages (16) in concentrations that are achieved in vivo. The authors suggested that tetracyclines may have several potential chondroprotective effects direct inhibition of matrix metalloproteinase activity and, by inhibition of nitric oxide production, further reduction of matrix metalloproteinase activity, reversal of reduced matrix synthesis, and reduced chondrocyte apoptosis. 

Xia, M., Sreedharan, S. P., Dazin, P., Damsky, C. H., and Goetzl, E. J. (1996b). Integrin-dependent induction of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane. J. Cell Biochemistry 61, 452 58. 

Hemozoin (in the form of a- and p-hematin) has been reported to suppress erythropoiesis (Casals-Pascual et al., 2006), and after endothelial cell ingestion suppresses ICAM-1 and PECAM-1 expression, as well as production of interleukin (IL)-6 (Taramelli et al., 1998), and it can lyse red blood cells by incorporation into the membrane (Omodeo-Sale et al., 2005). In its native form, hemozoin has been shown to inhibit the function and maturation of dendritic cells (Millington et al., 2006 Skorokhod et al., 2004 Urban and Todryk, 2006) and to enhance matrix metalloproteinase activity as well as tumor necrosis factor (TNF)-a production in monocytes (Prato... 

It has been demonstrated that EGCG can inhibit the matrix metalloproteinase activity at a relatively low dose. EGCG inhibits the activity of secreted MMP-2 and MMP-9 at concentrations of 8-13 pM. Meanwhile, 1 pM EGCG increased the expression of TIMP-1 and TIMP-2, proteins that inhibit the activity of activated MMPs. Because such concentrations of tea polyphenols are physiologically significant, this is an attractive mechanism for the observed anti-invasive and anti-angiogenic activities of EGCff and other tea polyphenols in vivo. Recently, similar observations of the inhibitory effects of tea polyphenols on the activities of MMPs have been made TE-3 appears to be the most active of the compounds examined in this respect (unpublished results). 

Ul. Uemura, S., Matsushita, H., Li, W., et al. Diabetes mellitus enhances vascular matrix metalloproteinase activity role of oxidative stress. Circ. Res. 88,1291-1298 (2001). 

Fu, X., S. Y. Kassim, W. C. Parks, and J. W. Heinecke. 2001. Hypochlorons add oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. J Biol Chem 276(44) 41279-87. 

E. E., and Ereeman, B.A. 2011. Electrophilic fatty acids regulate matrix metalloproteinase activity and expression, 286, 16074-16081. 

Characterisation of matrix metalloproteinase production by isolated lung fibroblasts, endothelial cells, type II epithelial cells, and alveolar macrophages revealed that only the macrophage has the same spectrum for matrix metalloproteinase activity as seen in the bronchoalveolar lavage fluids in lipopolysaccharide-induced acute lung injury in Long-Evans rats (Gibbs et al. 1999). 

Wu X-E, Eel M-J, Shu R-G, Tan R-X, Xu Q (2005) Eumigaclavine C, an lungal metabolite, improves experimental colitis in mice via downregulating Thl cytokine productimi and matrix metalloproteinase activity. Int Immunopharmacol 5 1543—1553... 

Suga M, lyonaga K, Okamoto T, et al. Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2000 162 1949-1956. 

EGCG also possesses a potential antimetastatic activity as revealed by inhibition of matrix metalloproteinase activity in mouse B16 melanoma cells (27). 

Jourquin, J., Tremblay E., Decanis, N., et al., 2003. Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate. Eur. J. Neurosci. 18,1507-1517. 

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