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Human cartilage

ADCOCKS c, COLLIN P and BUTTLE D J (2002) Catechins from green tea Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type 11 collagen degradation in vitro , JNutr, 132 (3), 341-6. [Pg.150]

Hakala BE, White C, Recklies AD 1993 Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem 268 25803-25810... [Pg.192]

Verheijden GF, Rijnders AW, Bos E et al 1997 Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis. Arthritis Rheum 40 1115—1125... [Pg.194]

Renkema, G.H., Boot, R.G., Au, F.L., Donker-Koopman, W.E., Strijland, A., Muijsers, A.O., Hrebicek, M. and Aerts, J.M. (1998) Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. European Journal of Biochemistry 251, 504-509. [Pg.217]

Roberts S et al (1996) Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine (Phila Pa 1976) 21(4) 415 120... [Pg.226]

The synovial arrays were incubated with the sera from patients with early and severe RA as well as healthy patients. Hierarchical clustering analysis revealed that autoreactive B-cell responses for citrullinated epitopes were present in a subset of patients with early RA, features which are predictive of the development of severe RA. In contrast, autoantibodies directed against native epitopes including several human cartilage gp39 peptides and type II collagen, were associated with features predictive of less severe RA. [Pg.207]

Antinflammatory DMARDs such as chloroquine, auranofin, sodium aurothiomalate, and dexamethasone have been shown to inhibit IL-1 synthesis [89]. Analogs of these compounds have exhibited potent inhibition of IL-1 a- induced cartilage resorption [90]. Elevated collagenase and proteoglycanase levels caused by IL-1 in human cartilage were found to be reduced by tiapro-... [Pg.425]

Blot L, Marcelis A, Devogelaer JP, Manicourt DH. Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human cartilage. Br J Pharmacol. 2000 131 1413-1421. [Pg.213]

Several authors use human cartilage from joint replacement surgery (e.g. Pelletier et al. 1989 Pelletier andMartel-Pelletier 1989), and some compare drug effects upon visually normal cartilage to those with fib-rillated or osteoarthritic cartilage (Lafeber et al. 1992, 1993 Verbruggen et al. 1989,1990). [Pg.247]

Martini, J., Tonsing, K., Dickob, M. and Anselmetti, D. (2005) 2-photon laser scanning microscopy on native human cartilage. Proc. SPIE 5860, 16-21. [Pg.320]

A6. Anderson, A. J., Some studies on the occurrence of sialic acid in human cartilage. Biochem. J. 78, 399-409 (1961). [Pg.223]

Collagen is a natural fibrous protein found in human cartilage, connective tissue, and bone. Glutaraldehyde cross-linked bovine collagen is a sterile, biocompatible, biodegradable, purified bovine dermocollagen cross-linked with glutaraldehyde, mixed in a phosphate-buffered saline solution. [Pg.885]

Two further perspectives on the use of tetracychnes in rheumatoid arthritis have been pubhshed (14,15). In addition to an effect on matrix metalloproteinases, the authors focused on a potential antiarthritic action of tetracyclines by their effects in the interaction between the generation of nitric oxide, matrix metalloproteinase release, and chondrocyte apoptosis. Both minocychne and doxycycline inhibit the production of nitric oxide from human cartilage and murine macrophages (16) in concentrations that are achieved in vivo. The authors suggested that tetracyclines may have several potential chondroprotective effects direct inhibition of matrix metalloproteinase activity and, by inhibition of nitric oxide production, further reduction of matrix metalloproteinase activity, reversal of reduced matrix synthesis, and reduced chondrocyte apoptosis. [Pg.3331]

Dudhia J, Davidson CM, Wells TM, Hardingham TE, Bayliss MT. Studies on the G3 domain of aggrecan from human cartilage. Ann NY Acad Sci 1996 785 245-247. [Pg.148]

Nguyen Q, Murphy G, Hughes CE, Mort JS, Roughley PJ. Matrix metallo-proteinases cleave at two distinct sites on human cartilage link protein. Biochem J 1993 295 595-598. [Pg.150]

Osborne-Lawrence SL, Sinclair AK, Hicks RC, Lacey SW, Eddy RE, Jr., Byers MG, Shows TB, Duby AD. Complete amino acid sequence of human cartilage link protein (CRTLl) deduced from cDNA clones and chromosomal assignment of the gene. Genomics 1990 8 562-567. [Pg.151]

M24. Mathews, M. B., and Clagov, S., Add mucopol rsaccharide patterns in aging human cartilage. J. Clin. Invest. 45,1103-1111 (1966). [Pg.92]

Human skin. Human cornea. Human cartilage. Human glumerular basement membrane. [Pg.71]

Vilim, Vr., Voburka, Z., Vytd ek, R., et al. (2003) Monoclonal Antibodies to Human Cartilage Oligomeric Matrix Protein Epitope Mapping and Characterization of Sandwich ELISA. Clinica ChimicaActa, 328 (1-2), 59-69. [Pg.260]

Figure 65 Cartoon representation of the proteoglycan-hyaluronic acid aggregates in human cartilage (left) and a simplified synthetic model system for this structure (right). Reprinted from Lienkamp, K. Noe, L. Breniaux, M.-H. etal. Macromolecules 40 7), 2486-2502, with permission from ACS. ... Figure 65 Cartoon representation of the proteoglycan-hyaluronic acid aggregates in human cartilage (left) and a simplified synthetic model system for this structure (right). Reprinted from Lienkamp, K. Noe, L. Breniaux, M.-H. etal. Macromolecules 40 7), 2486-2502, with permission from ACS. ...

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See also in sourсe #XX -- [ Pg.247 ]




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