Matrix metalloproteinases measurement

Sundstrom J, Evans JC, Benjamin EJ, Levy D, Larson MG, Sawyer DB, Siwik DA, Colucci WS, Sutherland P, Wilson PW, Vasan RS (2004) Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk factors and echo-cardiographic left ventricular measures the Framingham Heart Study. Circulation 109(23 ) 2850-2856.doi 10.1161/01. CIR.0000129318. 79570.84... 

MEASUREMENT OF MATRIX METALLOPROTEINASES (MMPS) AND TISSUE INHIBITORS OF METALLOPROTEINASES (TIMP) IN BLOOD AND URINE POTENTIAL CLINICAL APPLICATIONS... 

Considerable interest has evolved over the past decade in the measurement of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloprotei-nases (TIMPs) in blood and urine as an aid in the diagnosis and prognosis of disease. The goal of this chapter is to provide a comprehensive review of the subject with the focus on potential future developments and applications of the technology. 

Yl. Yamanaka, H., Matsuda, Y., Tanaka, M., Sendo, W., Nakajima, H., Taniguchi, A., and Kamatani, N. Y., Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum. 43, 852-858 (2000). 

Z3. Zucker, S., Hymowitiz, M., Conner, C., et al. Measurement of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in blood and tissues. Ann. New York Acad. Sci. 878, 212-227 (1999). 

Pugin et al. (75) compared IL-8, matrix metalloproteinases (MMP-2 and MMP-9), and procollagen peptide III in the pulmonary edema fluid of patients with ARDS or hydrostatic edema. IL-8, MMP-9, and PCPIII were all elevated in the ARDS edema fluid as compared with the hydrostatic edema fluids. The outcomes of the patients were not reported. Interestingly, the clinical severity of illness scores were similar in the patients with ARDS and cardiogenic edema, so the edema fluid measurements were better than clinical criteria at identifying the patients with severe lung injury. 

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