Matrix-assisted laser desorption/ionization in imaging mass spectrometry

Sugiura Y, Shimma S, Setou M. Two-step matrix application technique to improve ionization efficiency for matrix-assisted laser desorption/ionization in imaging mass spectrometry. Anal. Chem. 2006 78 8227-8235. [Pg.388]

In a separate study, a protocol for Matrix-assisted laser desorption-ionization (MALDI) imaging mass spectrometry (IMS) has been proposed.18 This IMS technique provides a new approach to visualize spatial distribution of thousands of molecular species, including peptides, proteins, and their metabolites in two- or three-dimensional levels. This approach may also provide a straightforward method of determining the tissue distribution of multiple peptides or proteins in a quantitative manner.18 Chu et al.19 reported a nondestructive molecular extraction method to obtain proteins from a single FFPE or frozen tissue section, without destroying the tissue morphology, such... [Pg.394]

Last but not the least, matrix-assisted laser-desorption ionization (MALDI) imaging mass spectrometry (IMS) caught a lot of attentions in the drug metabolism area. Drug distribution and individual metabolite distributions within... [Pg.249]

A modified version of 2DE and gel image analysis, with silver staining, autoradiography, and protein identification and measurement of peptide mass, uses matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) as a rapid and sensitive technique for identifying peptides. MALDI-TOF-MS applies well to protein detection in biological fluids.56 A second advantage of this technique is... [Pg.87]

Cheng, Z., Winant, R. C., and Gambhir, S. S. (2005). A new strategy to screen molecular imaging probe uptake in cell culture without radiolabeling using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Nucl. Med. 46 878-886. [Pg.379]

Crossman, L., McHugh, N. A., Hsieh, Y., Korfmacher, W. A., and Chen, J. (2006). Investigation of the profiling depth in matrix-assisted laser desorption/ionization imaging mass spectrometry. Rapid. Commun. Mass. Spectrom. 20 284-290. [Pg.379]

Hsieh, Y., Casale, R., Fukuda, E., Chen, J., Knemeyer, I., Wingate, J., Morrison, R., and Korfmacher, W. (2006a). Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue. Rapid Commun. Mass Spectrom. 20 965-972. [Pg.380]

Use of Matrix Assisted Laser Desorption/ Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs... [Pg.399]

Trim P, Henson C, Avery J, McEwen A, Snel M, Claude E, Marshall P, West A, Princivalle A, Clench M (2008) Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Anal Chem 80 8628-8634. doi 10.1021/ac8015467... [Pg.420]

Drexler D, Garrett T, Cantone J, Diters R, Mitroka J, Conaway M, Adams S, Yost R, Sanders M (2007) Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissue. J Pharmacol Toxicol Methods 55 279-288. doi 10.1016/j. vascn.2006.11.004... [Pg.420]

Bouslimani A, Bee N, Glueckmann M, Hirtz C, Larroque C (2010) Matrix-assisted laser desorption/ionization imaging mass spectrometry of oxaliplatin derivatives in heated intraoperative chemotherapy (HIPEC)-like treated rat kidney. Rapid Commun Mass Spectrom 24 415-421. doi 10.1002/rcm.4408... [Pg.422]

Bunch J, Clench M, Richards D (2004) Determination of pharmaceutical compounds in skin by imaging matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 18 3051-3060. doi 10.1002/rcm.l725... [Pg.422]

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