Molecular imaging probes

Cheng, Z., Winant, R. C., and Gambhir, S. S. (2005). A new strategy to screen molecular imaging probe uptake in cell culture without radiolabeling using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Nucl. Med. 46 878-886. 

Several academic partners and Siemens Medical Solutions USA Inc. (Molecular Imaging) in Culver City, USA, made the synthesis of an [18F]fluoride-radiolabeled molecular imaging probe, 2-deoxy-2-[18F]fluoro-D-glucose in an integrated microfluidic device (see Figure 5.1) [21]. Five sequential processes were made, and they are [18F]fluoride concentration, water evaporation, radiofluorination, solvent exchange and hydrolytic deprotection. The half-life of [lsF]fluorine (t1/2 = llOmin) makes rapid synthesis of doses essential. This is one of the first examples of an automated multistep synthesis in microflow fashion. 

Mulder W, Koole R, Brandwijk R, et al. Quantum dots with paramagnetic coating as a bimodal molecular imaging probe. Nano Lett 2006 6 1-6. 

Metal-catalyzed chck chemistry for molecular imaging probes 13 COC594. 

R573 Y. Shen and J. Mi, Molecular Imaging Probes for Integrin avPs , Zhongguo Aizheng Zazhi , 2010, 20, 303. 

There are currently no approved non-invasive diagnostic methods for hypoxic tumours and therefore there is a substantial need for an appropriate molecular imaging probe. The potential for Cu[ATSM] to act as a... 

The field of appHcation for amine precursors such as F- and C-labeled l-DOPA or 5-HTP has to be further investigated. These tracers could potentially be applied as first-line molecular imaging probes in pheochromocytomas/paragangliomas and also in medullary thyroid carcinomas. Furthermore, these tracers may play a promising role in somatostatin receptor negative tumors with positive immunohistochemical detection of serotonin as well as in insuKnomas. 

Nolting DN, Nickels ML, Huo N, Pham W (2012) Molecular imaging probe development a chemistry perspective. Am J Nucl Med Mol Imaging 2 273-306... 

Paudyal, R Paudyal, B. lida, Y. Oriuchi, N. Hanaoka, H. Tominaga, H. Ishikita, T. Yoshioka, H. Higuchi, T. Endo, K. Dual functional molecular imaging probe targeting CD20 with PET and optical imaging. Oncol. Rep. 2009,22,115-119. 

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