Mass spectrometry reflectron

The chemical compositions of the isolated Au SR clusters were investigated by mass spectrometry [15,16,18, 22,32-35]. TEM was used to confirm that the species detected by the mass spectrometer represents the clusters in the sample. Figure 3a is a schematic representation of the top view of the mass spectrometer, which consists of five stages of differentially pumped vacuum chambers. The apparatus accommodates two t5 pes of ion sources, electrospray ionization (ESI) and laser-desorption ionization (EDI), and a time-of-flight (TOE) mass spectrometer with a reflectron. Details of the apparatus and the measurement protocols are described below. 

R. J. Cotter, W. Griffith, and C. Jelinek. Tandem Time-of-Flight (TOF/TOF) Mass Spectrometry and the Curved-Field Reflectron. J. Chromatogr., B855(2007) 2-13. 

T. J. Cornish and R. J. Cotter. A Curved-Field Reflectron for Improved Energy Focusing of Product Ions in Time-of-Flight Mass Spectrometry. Rapid Commun. Mass Spectrom., 7(1993) 1037-1040. 

B.A. Mamyrin, Laser assisted reflectron time-of-flight mass spectrometry, hit. J. Mass Spectrom. Ion Proc., 131 (1994) 1-19. 

Strobel, F.H. Solouki, T. White, M.A. Russell, D.H. Detection of Femtomole and Sub-Femtomole Levels of Peptides by Tandem Magnetic Sector/Reflectron TOF Mass Spectrometry and MALDI. J. Am. Soc. Mass Spectrom. 1991,2, 91-94. 

Matrix assisted laser desorption ionization time-of-flight (MALDI-TOE) mass spectrometry was carried out with a PerSeptive Biosystems Voyager-DE-RP MALDl-TOF mass spectrometer. A 337-nm UV nitrogen laser producing 3-ns pulses was used in the reflectron mode. The samples were prepared by mixing 10 pi of a 0.1 M HAc solution of the sample with 20 pi of a solution of 3 mg/1 a-cyano-4-hydroxy cinnamic acid in wafer. One pi of that solution was loaded on the gold-sample plate. 

Li, M. X. Wu, J. T. Parus, S. Lubman, D. M. 1998. Development of a three-dimensional topographic map display for capillary electrophoresis/mass spectrometry with an ion trap/reflectron time-of-flight mass spectrometer detector applications to tryptic digests of isoforms of myelin basic protein. ./. Am. Soc. Mass Spectrom., 9,701-709. 

Kaufmann R, Chaurand P, Kirsch D, Spengler B. Post-source decay and delayed extraction in matrix-assisted laser desorption/ionization-reflectron time-of-flight mass spectrometry. Are there trade-offs . Rapid Commun Mass Spectrom 1996 10 1199-1208. 

Until now, most studies of dissociation dynamics of metastable cluster ions have been made using a double-focusing mass spectrometry method (Lifshitz et al. 1990 Lifshitz and Louage 1989, 1990 Stace 1986). As discussed herein, the novel technique of reflectron time-of-flight mass spectrometry is a valuable alternative approach to more standard methods. With carefully designed experiments, it is possible to derive both kinetic energy releases and decay fractions for... 

Figure 10 Inductively coupled plasma time-of-flight mass spectrometry (ICP-TOF-MS) spectrum for a 4-ppm solution of both Pb and Bi using the ion reflectron (average of 1000 shots). (From Ref. 40.)...

The mass spectrometry analysis was performed by the matrix assisted laser desorption/ionisation time-of-flight (S8-MALDI) technique using a Voyager-DE PRO Biospectrometry Workstation (Applied Biosystems, USA). Radiation pulses of 0.5 ns and 3 Hz frequency from N2 laser operating at 337 nm were used to desorb the species and negative/positive ions formed were detected in reflectron mode. Sulfur used as a matrix material was also dissolved in toluene and mixed with the samples solution prior to deposition onto a target. 

B. SPENGLER, D. KIRSCH and R. KAUFMANN obtain structural information with reflectron TOF mass spectrometry (MALDI post-source decay) [66],... 

Trajectories for CID fragmentation of ions of 500 Th. The focal points in energy of the product ions of 400 and 300 Th are indicated for a linear field reflectron and for a curved field reflectron. Reproduced (modified) from Cotter R.J., Time-Of-Flight Mass Spectrometry Instrumentation and Applications in Biological Research, ACS, Washington, DC, 1997, with permission. 

Figure 6.31. Positive-ion MALDI-TOF reflectron mode mass spectrum of grape seed extract (matrix 2,5-dihydroxybenzoic acid). (Reprinted from Journal of Agricultural and Food Chemistry, 48, Yang and Chien, Characterization of grape procyanidins using high-performance liquid chromatography/mass spectrometry and matrix-assisted laser desorption time-of-flight mass spectrometry, p. 3993, Copyright 2000, with permission from American Chemical Society.)...

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