Mass spectrometry continuous-flow fast atom bombardment

Caprioli, R.M., Continuous-Flow Fast Atom Bombardment Mass Spectrometry, Wiley, New York, 1990. [Pg.450]

Moseley, M. A., Deterding, L. J., Tomer, K. B., and Jorgenson, J. W. Coupling of capillary zone electrophoresis and capillary liquid chromatography with coaxial continuous-flow fast atom bombardment tandem sector mass spectrometry, /. Chromatogr., 480, 197, 1989. [Pg.419]

The mass spectra of mixtures are often too complex to be interpreted unambiguously, thus favouring the separation of the components of mixtures before examination by mass spectrometry. Nevertheless, direct polymer/additive mixture analysis has been reported [22,23], which is greatly aided by tandem MS. Coupling of mass spectrometry and a flowing liquid stream involves vaporisation and solvent stripping before introduction of the solute into an ion source for gas-phase ionisation (Section 1.33.2). Widespread LC-MS interfaces are thermospray (TSP), continuous-flow fast atom bombardment (CF-FAB), electrospray (ESP), etc. Also, supercritical fluids have been linked to mass spectrometry (SFE-MS, SFC-MS). A mass spectrometer may have more than one inlet (total inlet systems). [Pg.353]

CF-FAB MS Continuous-flow fast atom bombardment mass spectrometry... [Pg.752]

DGE a AC AMS APCI API AP-MALDI APPI ASAP BIRD c CAD CE CF CF-FAB Cl CID cw CZE Da DAPCI DART DC DE DESI DIOS DTIMS EC ECD El ELDI EM ESI ETD eV f FAB FAIMS FD FI FT FTICR two-dimensional gel electrophoresis atto, 10 18 alternating current accelerator mass spectrometry atmospheric pressure chemical ionization atmospheric pressure ionization atmospheric pressure matrix-assisted laser desorption/ionization atmospheric pressure photoionization atmospheric-pressure solids analysis probe blackbody infrared radiative dissociation centi, 10-2 collision-activated dissociation capillary electrophoresis continuous flow continuous flow fast atom bombardment chemical ionization collision-induced dissociation continuous wave capillary zone electrophoresis dalton desorption atmospheric pressure chemical ionization direct analysis in real time direct current delayed extraction desorption electrospray ionization desorption/ionization on silicon drift tube ion mobility spectrometry electrochromatography electron capture dissociation electron ionization electrospray-assisted laser desorption/ionization electron multiplier electrospray ionization electron transfer dissociation electron volt femto, 1CT15 fast atom bombardment field asymmetric waveform ion mobility spectrometry field desorption field ionization Fourier transform Fourier transform ion cyclotron resonance... [Pg.11]

M. A. Moseley, L. J. Deterding, K. B. Tomer, and J. W. Jorgenson. Nanoscale Packed-Capillary Liquid Chromatography Coupled with Mass Spectrometry Using a Coaxial Continuous-Flow Fast Atom Bombardment Interface. Anal. Chem., 63(1991) 1467-1473. [Pg.78]

R. M. Caprioli and W. T. Moore. Continuous-Flow Fast Atom Bombardment Mass Spectrometry. In Methods in Enzymology Mass Spectrometry, ed. J. A. McCloskey. Methods in Enzymology 193, Academic Press, San Diego, 1990, 214-237. [Pg.78]

L.J. Deterding, M.A. Moseley, K.B. Tomer and J.W. Jorgenson, Coaxial continuous flow fast atom bombardment in conjunction with tandem mass spectrometry for the analysis of biomolecules, Anal. Chem., 61 (1989) 2504-2511. [Pg.398]

Several years later, the next step in the application of MS-MS for mixture analysis was developed by Hunt et al. [3-5] who described a master scheme for the direct analysis of organic compounds in environmental samples using soft chemical ionisation (Cl) to perform product, parent and neutral loss MS-MS experiments for identification [6,7]. The breakthrough in LC-MS was the development of soft ionisation techniques, e.g. desorption ionisation (continuous flow-fast atom bombardment (CF-FAB), secondary ion mass spectrometry (SIMS) or laser desorption (LD)), and nebulisation ionisation techniques such as thermospray ionisation (TSI), and atmospheric pressure ionisation (API) techniques such as atmospheric pressure chemical ionisation (APCI), and electrospray ionisation (ESI). [Pg.152]

The first approaches to the coupling of liquid-phase separation techniques with mass spectrometry were designed for HPLC needs, starting in the 1970s with since-forgotten techniques such as direct liquid introduction (DLI) and moving belt. In the 1980s, techniques such as thermospray, continuous-flow-fast atom bombardment (CF-FAB), and particle beam arose. [Pg.338]

Wolfender, J.-L. et al.. Comparison of liquid chromatography/electrospray, atmospheric pressure chemical ionization, thermospray and continuous-flow fast atom bombardment mass spectrometry for the determination of secondary metabolites in crude plant extracts, J. Mass Spectrom. Rapid Commun. Mass Spectrom., S35, 1995. [Pg.35]

Basic Protocol 2 Fast Atom Bombardment, Liquid Secondary Ion Mass Spectrometry, and Continuous-Flow Fast Atom Bombardment of Carotenoids F2.4.2... [Pg.839]

Mass spectrometry is a valuble tool with which an abundancy of structural information may be obtained from a minute amount of material. Capillary electrophoresis may be interfaced with mass spectrometry by electrospray ionization [124-126] or continuous-flow, fast-atom bombardment methods [127,128]. Several reviews discuss applications of the interfacing techniques, and address the attributes and disadvantages associated with these methods [129,130]. Critical parameters involved in the optimization of CE-electrospray ionization mass spectrometry analysis have been reviewed as well [131],... [Pg.374]

R.M. Caprioli, Continuous-flow Fast Atom Bombardment Mass Spectrometry, John Wiley and Sons, Chichester, 1990. [Pg.327]

Mass spectrometrie techniques that include continuous flow fast atom bombardment (FAB), electrospray ionization (ESI), and matrix assisted laser desorption (MALDI) have been applied successfully to protein structure investigations. (3) The hyphenation of electrospray ionization mass... [Pg.165]

Over 30 years of liquid chromatography-mass spectrometry (LC-MS) research has resulted in a considerable number of different interfaces (Ch. 3.2). A variety of LC-MS interfaces have been proposed and built in the various research laboratories, and some of them have been adapted by instmment manufacturers and became commercially available. With the advent in the early 1990 s of interfaces based on atmospheric-pressure ionization (API), most of these interfaces have become obsolete. However, in order to appreciate LC-MS, one carmot simply ignore these earlier developments. This chapter is devoted to the older LC-MS interfaces, which is certainly important in understanding the histoiy and development of LC-MS. Attention is paid to principles, instrumentation, and application of the capillary inlet, pneumatic vacuum nebulizers, the moving-belt interface, direct liquid introduction, continuous-flow fast-atom bombardment interfaces, thermospray, and the particle-beam interface. More elaborate discussions on these interfaces can be found in previous editions of this book. [Pg.73]

R.M. Caprioli (Ed.), Continuous-flow fast-atom bombardment mass spectrometry, 1990, Wiley, New York. [Pg.99]

Until 1988, the mass spectrometric analysis of peptides and proteins was difficult. Some results were achieved using (continuous-flow) fast-atom bombardment (FAB) and Cf plasma desorption. The major breakthrough in the characterization of proteins by mass spectrometry (MS) is due to the introduction of matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) in 1988. Currently, peptides and proteins form the compound class most intensively studied by MS. This is primarily due to the prominent role ESI-MS and MALDI-MS play in the field of proteomics. [Pg.441]

P. S. Kokkonen, Continuous-flow fast atom bombardment liquid chromatography mass spectrometry in bioanalysis, Ph.D. thesis, Oulou University, 1991. [Pg.959]

Caprioli, R.M., Continuous-Flow Fast Atom Bombardment Mass Spectrometry, Wiley, New York, 1990. Chapman, J.R., Computers in Mass Spectrometry, Academic Press, London, 1978. [Pg.450]

Reinhoud, N. J., Niessen, W. M. A., Tjaden, U. R., Gramberg, L. G., Verheij, E. R. and van der Greef, J. Performance of a liquid-junction interface for capillary electrophoresis mass spectrometry using continuous-flow fast-atom bombardment Rapid Commun. Mass Spectrom. 3 348-351, 1989. [Pg.296]

Combined liquid chromatography/mass spectrometry (LC/MS)can play an important role in both qualitative and quantitative bioanalysis. LC/MS can be performed with a number of interfaces. Three interfaces are presently available in our laboratories i.e., the thermospray interface (TSP), the moving-belt interface (MBI), and continuous-flow fast atom bombardment (CF-FAB). These interfaces are supplementary with respect to their applicability and the type of information that can be obtained. [Pg.179]

In some instances, microdialysis sampling can be coupled on-line with mass spectrometry without prior separation or cleanup with techniques such as GC or LC. Continuous flow fast atom bombardment (cfFAB) has been used for the ionization of microdialysis samples without prior sample preparation. Coupling micro-dialysis directly to mass spectrometry via FAB was more feasible with cfFAB because it provided for a more robust, efficient ionization and prevented source fouling. [Pg.389]