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Mass spectra compound

Treatment of 41b with bromocyanide (BrCN) at 70 °C for 3 h afforded the amino compound 53 (76%). The structures of all the newly synthesized compounds were confirmed by the H, NMR, and mass spectra. Compounds 55 and 52 were identified by the homo- and heteronuclear spectra, as well as from comparison to the 1,2,4-triazolo-azipene derivatives prepared previously [22] (Scheme 10). [Pg.140]

The presence of hydrophenanthrene isomers was indicated by the observation of numerous GLC peaks with identical parent ions but different fragment ions in their mass spectra. Compounds with methyl substituents always have more intense M -15 ions than those with unsubstituted six-membered rings. Considering the complexity of the total reaction mixtures, liquid chromatography (HPLC) was used to concentrate more discrete solvent fractions for C-NMR study. [Pg.371]

Pare compound 179 can be i solated by gas chromatography (100 °C, phenyl silicon oil type 0 S 26.14 (PE) on Sterchamol, 6 m column, 1 atm helium). By a study of the nmr, i.r. and mass spectra, compound 179 is identified, and compared with that produced by a different synthesis S4 The yield was 30%. As the following possibilities for a hydrosilylation exist, this low yield is not surprising ... [Pg.113]

There are many studies available concerning the characterization of interface and ionization performance for the thermospray LC-MS analysis of pesticides, herbicides and insecticides, the improvement of detection limits and information content of the mass spectra. Compound classes most frequently studied are the carbamates, organophosphorous pesticides, triazine and phenylurea herbicides, chlorinated phenoxy acetic acids, and sulphonylureas. [Pg.1190]

Gas chromatographic mass spectral analysis of the methyl esters showed three major compounds. Table II lists the retention times, mass spectra of compotinds and the struct ares assigned to the parent compound or the largest fragment observed on the mass spectrum. Compounds eluting from the column at temperatures above 300 C yielded poor mass spectra as the transfer lines including the jet... [Pg.393]

In the case of mixtures, especially those of petroleum, a variety of compounds can give ions having the same mass the mass spectrum is then the sum of the spectra of each component ... [Pg.49]

Time-of-flight mass spectrometers have been used as detectors in a wider variety of experiments tlian any other mass spectrometer. This is especially true of spectroscopic applications, many of which are discussed in this encyclopedia. Unlike the other instruments described in this chapter, the TOP mass spectrometer is usually used for one purpose, to acquire the mass spectrum of a compound. They caimot generally be used for the kinds of ion-molecule chemistry discussed in this chapter, or structural characterization experiments such as collision-induced dissociation. Plowever, they are easily used as detectors for spectroscopic applications such as multi-photoionization (for the spectroscopy of molecular excited states) [38], zero kinetic energy electron spectroscopy [39] (ZEKE, for the precise measurement of ionization energies) and comcidence measurements (such as photoelectron-photoion coincidence spectroscopy [40] for the measurement of ion fragmentation breakdown diagrams). [Pg.1354]

The second step, the so called generation, created only those structures which complied with the given constraints, and imposed additional restrictions on the compounds such as the number of rings or double bonds. The third and final phase, the tester phase, examined each proposed solution for each proposed compound a mass spectrum was predicted which was then compared with the actual data of the compound. The possible solutions were then ranked depending on the deviation between the observed and the predicted mass spectra. [Pg.480]

In contrast to IR and NMR spectroscopy, the principle of mass spectrometry (MS) is based on decomposition and reactions of organic molecules on theii way from the ion source to the detector. Consequently, structure-MS correlation is basically a matter of relating reactions to the signals in a mass spectrum. The chemical structure information contained in mass spectra is difficult to extract because of the complicated relationships between MS data and chemical structures. The aim of spectra evaluation can be either the identification of a compound or the interpretation of spectral data in order to elucidate the chemical structure [78-80],... [Pg.534]

The amino add analysis of all peptide chains on the resins indicated a ratio of Pro Val 6.6 6.0 (calcd. 6 6). The peptides were then cleaved from the resin with 30% HBr in acetic acid and chromatogra phed on sephadex LH-20 in 0.001 M HCl. 335 mg dodecapeptide was isolated. Hydrolysis followed by quantitative amino acid analysis gave a ratio of Pro Val - 6.0 5.6 (calcd. 6 6). Cycll2ation in DMF with Woodward s reagent K (see scheme below) yielded after purification 138 mg of needles of the desired cyc-lododecapeptide with one equiv of acetic add. The compound yielded a yellow adduct with potassium picrate, and here an analytically more acceptable ratio Pro Val of 1.03 1.00 (calcd. 1 1) was found. The mass spectrum contained a molecular ion peak. No other spectral measurements (lack of ORD, NMR) have been reported. For a thirty-six step synthesis in which each step may cause side-reaaions the characterization of the final product should, of course, be more elaborate. [Pg.236]

Not only the molecular ion peak but all the peaks m the mass spectrum of benzene are accompanied by a smaller peak one mass unit higher Indeed because all organic com pounds contain carbon and most contain hydrogen similar isotopic clusters will appear m the mass spectra of all organic compounds... [Pg.569]

Some classes of compounds are so prone to fragmentation that the molecular ion peak IS very weak The base peak m most unbranched alkanes for example is m/z 43 which IS followed by peaks of decreasing intensity at m/z values of 57 71 85 and so on These peaks correspond to cleavage of each possible carbon-carbon bond m the mol ecule This pattern is evident m the mass spectrum of decane depicted m Figure 13 42 The points of cleavage are indicated m the following diagram... [Pg.570]

Deduce the structure of a compound having the mass spectrum and H NMR spectrum pre sented in Figure 13 48... [Pg.580]

A compound CgHi40 has the C NMR spectrum shown in Figure 15 11 Its mass spectrum has a prominent peak at m/z 31 Suggest a reasonable structure for this compound... [Pg.664]

Compound A and compound B are isomers having the molecular formula C10H12O The mass spectrum of each compound contains an abundant peak at m/z 105 The NMR spectra of com pound A (Figure 17 23) and compound B (Figure 17 24) are shown Identify these two isomers... [Pg.753]

The mass spectrum is a fingerprint for each compound because no two molecules are fragmented and ionized in exactly the same manner on electron-impact ionization. In reporting mass spectra the data are normalized by assigning the most intense peak (denoted as base peak) a value of 100. Other peaks are reported as percentages of the base peak. [Pg.815]

Mass spectrum of a carbon compound with (a) and without (b) the C isotopes. [Pg.16]

The importance of linked scanning of metastable ions or of ions formed by induced decomposition is discussed in this chapter and in Chapter 34. Briefly, linked scanning provides information on which ions give which others in a normal mass spectrum. With this sort of information, it becomes possible to examine a complex mixture of substances without prior separation of its components. It is possible to look highly specifically for trace components in mixtures under circumstances in which other techniques could not succeed. Finally, it is possible to gain information on the molecular structures of unknown compounds, as in peptide and protein sequencing (see Chapter 40). [Pg.235]

Once a mass spectrum from an eluting component has been acquired, the next step is to try to identify the component either through the skill of the mass spectroscopist or by resorting to a library search. Most modem GC/MS systems with an attached data station include a large library of spectra from known compounds (e.g., the NIST library). There may be as many as 50,000 to 60,000 stored spectra covering most of the known simple volatile compounds likely to be met in analytical work. Using special search routines under the control of the computer, one can examine... [Pg.257]

In a process similar to that described in the previous item, the stored data can be used to identify not just a series of compounds but specific ones. For example, any compound containing a chlorine atom is obvious from its mass spectrum, since natural chlorine occurs as two isotopes, Cl and Cl, in a ratio of. 3 1. Thus its mass spectrum will have two molecular ions separated by two mass units (35 -i- 2 = 37) in an abundance ratio of 3 1. It becomes a trivial exercise for the computer to print out only those scans in which two ions are found separated by two mass units in the abundance ratio of 3 1 (Figure 36.10). This selection of only certain ion masses is called selected ion recording (SIR) or, sometimes, selected ion monitoring (SIM, an unfortunate... [Pg.259]

Comparison of the mass spectrum from a target compound (top), with the three best fits from the library of standard spectra (lower three traces). The closeness of fit of the mass spectra and the chromatographic retention time lead to a positive identification of 2, 6-dimethylheptane. [Pg.300]

When a mass spectrum has been acquired by the spectrometer/computer system, it is already in digital form as m/z values versus peak heights (ion abundances), and it is a simple matter for the computer to compare each spectrum in the library with that of the unknown until it finds a match. The shortened search is carried out first, and the computer reports the best fits or matches between the unknown and spectra in the library. A search of even 60,000 to 70,000 spectra takes only a few seconds, particularly if transputers are used, thus saving the operator a great deal of time. Even a partial match can be valuable because, although the required structure may not have been found in the library, it is more than likely that some of the library compounds will have stractural pieces that can be recognized from a partial fit and so provide information on at least part of the structure of the unknown. [Pg.323]

Assuming that the mass spectrometer has sufficient mass resolution, the computer can prepare accurate ma.ss data on the m/z values from an unknown substance. To prepare that data, the system must acquire the mass spectrum of a known reference substance for which accurate masses for its ions are already known, and the computer must have a stored table of these reference masses. The computer is programmed first to inspect the newly acquired data from the reference compound in comparison with its stored reference spectrum if all is well, the system then acquires data from the unknown substance. By comparison and interpolation techniques using the known reference... [Pg.323]

Naturally occurring isotopes of any element are present in unequal amounts. For example, chlorine exists in two isotopic forms, one with 17 protons and 18 neutrons ( Cl) and the other with 17 protons and 20 neutrons ( Cl). The isotopes are not radioactive, and they occur, respectively, in a ratio of nearly 3 1. In a mass spectrum, any compound containing one chlorine atom will have two different molecular masses (m/z values). For example, methyl chloride (CH3CI) has masses of 15 (for the CH3) plus 35 (total = 50) for one isotope of chlorine and 15 plus 37 (total = 52) for the other isotope. Since the isotopes occur in the ratio of 3 1, molecular ions of methyl chloride will show two molecular-mass peaks at m/z values of 50 and 52, with the heights of the peaks in the ratio of 3 1 (Figure 46.4). [Pg.339]

A diagrammatic illustration of the effect of an isotope pattern on a mass spectrum. The two naturally occurring isotopes of chlorine combine with a methyl group to give methyl chloride. Statistically, because their abundance ratio is 3 1, three Cl isotope atoms combine for each Cl atom. Thus, the ratio of the molecular ion peaks at m/z 50, 52 found for methyl chloride in its mass spectrum will also be in the ratio of 3 1. If nothing had been known about the structure of this compound, the appearance in its mass spectrum of two peaks at m/z 50, 52 (two mass units apart) in a ratio of 3 1 would immediately identify the compound as containing chlorine. [Pg.340]

MS is a means of examining a compound, also in the gas phase, so that its stmcture or identity can be deduced from its mass spectrum. MS alone is not good for examining mixtures because the mass spectrum of a mixture is actually a complex of overlapping spectra from the individual components in the mixture. [Pg.414]

The energy difference between diazirine and diazomethane, interesting from the point of view of their isomerism, came from MS measurements (63JCP(39)3534). The appearance potentials of the CH2 ion, common to both compounds, yielded a difference in heats of formation of 125kJmor A strong peak in the mass spectrum of 3-chloro-3-methyl-diazirine (50) with relative mass 55 was ascribed to the methyldiazirinium ion (51). [Pg.204]

Understanding how molecules fragment upon electron impact pennits a mass spectrum to be analyzed in sufficient detail to deduce the structure of an unknown compound. Thousands of compounds of known structure have been examined by mass spectrometry, and the fragmentation patterns that characterize different classes are well documented. As various groups are covered in subsequent chapters, aspects of their fragmentation behavior under conditions of electron impact will be described. [Pg.573]


See other pages where Mass spectra compound is mentioned: [Pg.352]    [Pg.478]    [Pg.75]    [Pg.919]    [Pg.252]    [Pg.29]    [Pg.409]    [Pg.568]    [Pg.583]    [Pg.16]    [Pg.237]    [Pg.255]    [Pg.258]    [Pg.264]    [Pg.266]    [Pg.266]    [Pg.289]    [Pg.344]    [Pg.348]    [Pg.348]    [Pg.60]    [Pg.41]    [Pg.550]    [Pg.1032]    [Pg.568]   
See also in sourсe #XX -- [ Pg.120 ]




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Aromatic compounds mass spectra

Boron compounds, mass spectra

Carbon compound, mass spectrum

Carbonyl compounds mass spectra

Carbonyl compounds, Diels-Alder reaction mass spectra

Chlorine and Bromine-Containing Compounds in a Mass Spectrum

Cyano compounds mass spectra

Dimethylated compound, mass spectrum

Iron compounds mass spectrum

Mass Spectra of Common Compound Classes

Mass Spectra of Metallocenes and Related Compounds

Mass Spectra of Organometallic Compounds

Mass Spectra of Other Organic Compound Classes

Mass spectra identify compound

Mass spectrum single compound

Metal cluster compounds mass spectra

Nitro compounds mass spectra

Nitrogen-Containing Compounds in a Mass Spectrum

Organometallic compounds mass spectra

Osmium compounds mass spectrum

Phosphorus compounds, mass spectra

Silver compounds mass spectra

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