Markowitz

Bates, Determination of pH, Theory and Practice, Wiley, New York, 1964, pp. 121-122. t Elving, Markowitz, and Rosenthal, Awfl/. Chem., 28 1179 (1956). 

Landrigan PJ, Claudio L, Markowitz SB, et al. 1999. Pesticides and inner-city children Exposures, risks, and prevention. Environ Health Perspect 107(Suppl. 3) 431-437. 

Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M (1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373 123-126... 

Nelfinavir. Using structure-based design in conjunction with predicted oral pharmacokinetics, NFV was identified and found to have potent inhibition of HIV-1 in vitro with an IC50 in the 2nM range (Kaldor et al. 1997). Clinical trials of NFV revealed robust and sustained reductions in HIV-1 RNA with over half of all subjects attaining a persistent 1.6 logxo reduction at 12 months, in conjunction with a mean increase in CD4 cells of 180-200 per mm (Markowitz et al. 1998). In subjects... 

Esposito D, Craigie R (1999) HIV integrase structure and function. Adv Virus Res 52 319-333 Evering TH, Markowitz M (2007) Raltegravir (MK-0518) an integrase inhibitor for the treatment of HlV-1. Drugs Today (Bare) 43 865-877... 

Louie M, Hogan C, Di Mascio M, Hurley A, Simon V, Rooney J, Ruiz N, Brun S, Sun E, Perelson AS, Ho DD, Markowitz M (2003) Determining the relative efficacy of highly active antiretroviral therapy. J Infect Dis 187 896-900... 

Markowitz M, Nguyen BY, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, Prada G, Morales-Ramirez JO, Crumpacker CS, Isaacs RD, Glide LR, Wan H, Miller MD, Wenning LA, Teppler H Protocol 004 Part II Study Team (2007) Rapid and durable antiretroviral effect... 

Delwart EL, Pan H, Neumann A, Markowitz M (1998) Rapid, transient changes at the env locus of plasma Human Immunodeficiency Virus type 1 populations during the emergence fo protease inhibitor resistance. J Virol 72 2416-2421... 

Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD. HlV-1 dynamics in vivo virion clearance rate, infected cell life-span, and viral generation time. Science 1996 271 1582-6. 

Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, Quinn TC, Chadwick K, MargoUck J, Brookmeyer R, Gallant J, Markowitz M, Ho DD, Richman DD, SUiciano RF (1997) Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278(5341) 1295-1300... 

The risk of developing colonic cancer is raised in UC, particularly in those with long-standing extensive disease (Lennard-Jones et al., 1990). The mechanism of this increased susceptibility is unknown, although it is tempting to speculate that it is related to inflammation and resulting oxidative damage to DNA. As yet there is little evidence to support this contention. Markowitz et al. (1988) have reported a decrease in constituent and oxidant-induced adenosine diphosphate ribosyl... 

Markowitz, M.M., Rozen, P., Pero, R.W., Tobi, M. and Miller, D.G. (1988). Hydrogen peroxide induced adenosine diphosphate ribosyl transferase (ADPRT) response in patients with inflammatory bowel disease. Gut 29, 1680-1686. 

These differences may become particularly germane if co-prescribing with some antipsychotics is undertaken. For example, in certain individuals, combinations of clozapine with benzodiazepines may lead to unexpected adverse events, including delirium and augmented respiratory depression (Jackson, Markowitz Brewer-ton, 1995 Grohmann et al, 1989). Presumably if there are additive or synergistic effects of ethnicity on clearance of one or both substances, adverse events may be enhanced. Similar interactions are theoretically possible with olanzapine, as adverse interactions have been described between olanzapine and benzodiazepines, at least in the elderly (Kryzhanovskaya etal, 2006). 

Jackson, C.W., Markowitz, J. S. Brewerton, T. D. (1995). Delirium associated with clozapine and benzodiazepine combinations. Ann. Clin. Psychiatry, 7, 139—41. 

David Rosner and Gerald Markowitz. Safety and Health as a Class Issue , The Worker s Health Bureau of America during the 1920s. In Dying for Work Workers Safety and Health in Twentieth-Century America, David Rosner and Gerald Markowitz, eds. Bloomington, IN. Indiana University Press (1987) 53-64. 

Zinc is in the active site of ALAD and can play a protective role in lead intoxication by reversing the enzyme-inhibiting effects of lead. Children with high PbB levels (50-67 pg/dL) were reported to consume less zinc than children with lower PbB (12-29 pg/dL) (Johnson and Tenuta 1979). In a group of 13 children, Markowitz and Rosen (1981) reported that the mean serum zinc levels in children with... 

Markowitz ME Montefiore Medical Center, New York, NY Examine the interaction between elevated lead and low iron levels on the response to clinical intervention in young children between 18 and 30 months of age National Institute of Child Health And Human Development... 

Markowitz ME, Rosen JF. 1981. Zinc (Zn) and copper (Cu) metabolism in CaNa2 EDTA-treated children with plumbism. PediatrRes 15 635. 

Markowitz ME, Weinberger HL. 1990. Immobilization-related lead toxicity in previously lead-poisoned children. Pediatrics 86 455-457. 

Morris V, Markowitz ME, Rosen JF. 1988. Serial measurements of aminolevulinic acid dehydratase in children with lead toxicity. J Pediatr 112 916-919. 

Rosen JF, Markowitz ME, Jenks ST, et al. 1987. L-X-ray fluorescence (XRF) A rapid assessment of cortical bone lead (Pb) in Pb-toxic children. Pedia Res 21 287A. 

Ruff HA, Markowitz ME, Bijur PE, et al. 1996. Relationships among blood lead levels, iron deficiency, and cognitive development in two-year-old children. Environ Health Perspect 104(2) 180-185. 

Saenger P, Markowitz ME, Rosen JF. 1984. Depressed excretion of 6P-hydroxycortisol in lead-toxic children. J Clin Endocrinol Metab 58 363-367. 

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