Serum zinc

E., Lachica, M., Abad-Lacruz, A., Gil, A., Humbert, P., Boix, J. and Gassull, M.A. (1990). Serum zinc, copper, and selenium levels in inflammatory bowel disease effect of total enteral nutrition on trace element status. Am. J. Gastroenterol. 85, 1584-1589. 

Mateo, M.C., Bustamante, J. and Cantalapredia, M.A. (1978). Serum zinc, copper and insulin in diabetes mellitus. Biomedicine 29, 56-58. 

Nutritional considerations Contains soy bean oil, egg lecithin, and glycerol. Provides 1.1 kcal/mL of emulsion may need to adjust nutritional regimen. One formulation contains EDTA. Prolonged therapy with the EDTA-containing product may decrease serum zinc levels. May need to monitor serum zinc levels and supplement. 

Zinc is in the active site of ALAD and can play a protective role in lead intoxication by reversing the enzyme-inhibiting effects of lead. Children with high PbB levels (50-67 pg/dL) were reported to consume less zinc than children with lower PbB (12-29 pg/dL) (Johnson and Tenuta 1979). In a group of 13 children, Markowitz and Rosen (1981) reported that the mean serum zinc levels in children with... 

Signs of chronic zinc poisoning evident after 12-14 months. Signs included reduced appetite, emaciation, submandibular edema, diarrhea, moderate anemia, elevated serum zinc (4.3-6.0 mg/L vs. normal 1.8-2.1), liver Zn (420-1600 mg/kg DW vs. normal 72-248), kidney Zn (910-1680 mg/kg DW vs. normal 40-114), and low serum calcium and magnesium. 

Hemolytic anemia, vomiting, salivation, serum zinc dropped from 29 mg/L to 4.4 mg/L 15 days after coins were surgically removed (normal dog serum Zn values range between 0.6 and 2.0 mg/L). 

Weanling foals, age 3 months, fed diets containing 7.7 mg copper/kg plus 29, 250,1000,or2000mgZn/kg ration for 15 weeks. At start, serum zinc level was 0.6 mg/L and serum copper level 1.4 mg/L... 

Foals fed 29 or 250 mg Zn/kg diets had normal serum copper and zinc concentrations. Those fed 1000 or 2000 mg Zn/kg diet became hypocupremic in 5 to 6 weeks and developed lameness owing to cartilaginous disease similar to osteochondritis dessicous. Foals fed high zinc diets became lame when serum copper fell to 0.3 mg/L for >1 week at end of study arthritic foals had <0.2 mg copper/L serum. Serum zinc concentrations rose to >2 mg/L within 2 weeks at 1000 or 2000 mg Zn/kg diet liver zinc was <333 mg/kg DW at diets of <250 mg Zn/kg, 2728-3511 mg/kg DW at 1000 mg Zn/kg diet, and 4364-4524 mg/kg DW at the highest dietary loading of 2000 mg Zn/kg in 15 weeks Decreased growth, lameness, bone deformities, death. 

In the absorption study conducted by Istfan et al. (47), zinc balances were also determined. Mean zinc balances were positive and serum zinc levels were... 

The administration of large doses of glucocorticoids to patients with major burns presenting with low cardiac output has been reported to produce a reversible drop in serum zinc, which might lead to impaired tissue repair (SED-8, 824), but it is not clear whether this has clinical effects. 

Heinemann G. [Plasma iron, serum copper, and serum zinc during therapy with ovulation inhibitors.JMed Klin 1974 69(20) 892-6. 

Long-term or intensive corticosteroid or chelation therapy can lead to a sustained decrease in serum ziric levels, resulting in delayed healing of wounds and ulcers. Although the mechanism is not known, inclusion of zinc salts in the diet so as to raise blood serum zinc levels to normal also restored healing rates to normal25, 26 ... 

Vos JG, Kreeftenberg JG, Engel HWB, et al. 1978. Studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression and decreased resistance to infection endotoxin hypersensitivity, serum zinc concentrations and effect of thymosin treatment. Toxicology 9 75-86. 

Increased urinary zinc excretion coupled with decreased serum zinc concentration and the observed symptoms follow acute zinc depletion with enough consistency that it is relatively simple for an alert physician to establish the diagnosis. However, it is this awareness and the protean nature of the symptoms which complicate its diagnosis. Indeed, the full-blown clinical picture... 

Mean blood serum zinc levels of the vegetarian subjects was 75.5 ug/dl 4.81 with a range of 67.9 - 86.0 ug/dl and that for the omnivore subjects was 72.6 ug/dl 5.70 with a range of 64.8 -83.1 ug/dl. Blood serum zinc levels were weakly positively correlated with intake levels but with the number of subjects Involved, this correlation was not statistically significant. 

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